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Feasibility and evaluation of a large-scale external validation approach for ...
Abstract Background To demonstrate how the Observational Healthcare Data Science and Informatics (OHDSI) collaborative network and standardization can be utilized to scale-up... -
Perioperative statin therapy in cardiac and non-cardiac surgery: a systematic...
Abstract Background The effects of perioperative statin therapy on clinical outcome after cardiac or non-cardiac surgery are controversial. We aimed to assess the association... -
Involving general practice trainees in clinical practice guideline adaptation
Abstract Background It is unclear whether it is feasible to involve residents in guideline development or adaptation. We designed a multifaceted training program that combines... -
Complex microseismic activity and depth-dependent stress field changes in Wak...
Abstract We examined the spatial relationship between seismicity and upper crustal structure in the Wakayama region, northwestern Kii Peninsula, Japan, by investigating... -
INSPECT: extending plane-casting for 6-DOF control
Abstract INSPECT is a novel interaction technique for 3D object manipulation using a rotation-only tracked touch panel. Motivated by the applicability of the technique on... -
Projecting prevalence, costs and evaluating simulated interventions for diabe...
Abstract Background Diabetes-related end stage renal disease (DM-ESRD) is a devastating consequence of the type 2 diabetes epidemic, both of which disproportionately affect... -
BioReader: a text mining tool for performing classification of biomedical lit...
Abstract Background Scientific data and research results are being published at an unprecedented rate. Many database curators and researchers utilize data and information from... -
Guiding electron orbits with chirped light
We demonstrate that chirped light is effective in shrinking or expanding a class of nonspreading electron eigenstate wave packets in Rydberg atoms. -
Challenges with study procedure fidelity when conducting household survey: re...
Abstract Objectives The aim of the study was to identify reasons for protocol deviations during conduct of large epidemiological surveys despite training of field workers,... -
Multiphoton in vivo imaging with a femtosecond semiconductor disk laser
We use an ultrafast diode-pumped semiconductor disk laser (SDL) to demonstrate several applications in multiphoton microscopy. The ultrafast SDL is based on an optically pumped... -
Repeat: a framework to assess empirical reproducibility in biomedical research
Abstract Background The reproducibility of research is essential to rigorous science, yet significant concerns of the reliability and verifiability of biomedical research have... -
Automation bias in electronic prescribing
Abstract Background Clinical decision support (CDS) in e-prescribing can improve safety by alerting potential errors, but introduces new sources of risk. Automation bias (AB)... -
DNetDB: The human disease network database based on dysfunctional regulation ...
Abstract Disease similarity study provides new insights into disease taxonomy, pathogenesis, which plays a guiding role in diagnosis and treatment. The early studies were... -
Millstone: software for multiplex microbial genome analysis and engineering
Abstract Inexpensive DNA sequencing and advances in genome editing have made computational analysis a major rate-limiting step in adaptive laboratory evolution and microbial... -
Frequency of arrhythmia symptoms and acceptability of implantable cardiac mon...
Abstract Background Arrhythmia-related complications and sudden death are common in dialysis patients. However, routine cardiac monitoring has so far not been feasible.... -
The French National Registry of patients with Facioscapulohumeral muscular dy...
Abstract Background Facioscapulohumeral muscular dystrophy is a rare inherited neuromuscular disease with an estimated prevalence of 1/20,000 and France therefore harbors about... -
Horizontal gene transfer is not a hallmark of the human genome
Abstract Crisp et al. recently reported that 145 human genes have been horizontally transferred from distant species. Here, I re-analyze those genes listed by Crisp et al. as... -
Development and validation of a model for the adoption of structured and stan...
Abstract Background Healthcare professionals provide care to patients and during that process, record large quantities of data in patient records. Data in an Electronic Health... -
Multifocal optical nanoscopy for big data recording at 30 TB capacity and gig...
The onrushing challenge to store the exponentially increasing amount of information generated each year with sustainable big data techniques has compelled ongoing technical... -
Interventions to prevent hemodynamic instability during renal replacement the...
Abstract Background Hemodynamic instability during renal replacement therapy (HIRRT) in the form of intradialytic hypotension (IDH) is a frequent complication of hemodialysis in...
