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s·nr: a visual analytics framework for contextual analyses of private and pub...
Abstract Background Next-Generation Sequencing (NGS) has been widely accepted as an essential tool in molecular biology. Reduced costs and automated analysis pipelines make the... -
Omalizumab in patients with severe asthma and persistent sputum eosinophilia
Abstract Omalizumab, a recombinant humanized monoclonal antibody targeting the IgE molecule, is the first biologic approved for moderate-to-severe allergic asthmatics, who... -
ISSEC: inferring contacts among protein secondary structure elements using de...
Abstract Background The formation of contacts among protein secondary structure elements (SSEs) is an important step in protein folding as it determines topology of protein... -
CellTag Indexing: genetic barcode-based sample multiplexing for single-cell g...
Abstract High-throughput single-cell assays increasingly require special consideration in experimental design, sample multiplexing, batch effect removal, and data... -
Applicability of RNA standards for evaluating RT-qPCR assays and platforms
Abstract The availability of diverse RT-qPCR assay formats and technologies hinder comparability of data between platforms. Reference standards to facilitate platform evaluation... -
Development of a benchmark tool for cancer centers; results from a pilot exer...
Abstract Background Differences in cancer survival exist between countries in Europe. Benchmarking of good practices can assist cancer centers to improve their services aiming... -
CIDR: Ultrafast and accurate clustering through imputation for single-cell RN...
Abstract Most existing dimensionality reduction and clustering packages for single-cell RNA-seq (scRNA-seq) data deal with dropouts by heavy modeling and computational... -
Complex microseismic activity and depth-dependent stress field changes in Wak...
Abstract We examined the spatial relationship between seismicity and upper crustal structure in the Wakayama region, northwestern Kii Peninsula, Japan, by investigating... -
Current infection control practices used in Australian and New Zealand cystic...
Abstract Background The 2013 update of the Infection Prevention and Control (IP&C) Guideline outlined recommendations to prevent the spread of CF respiratory pathogens. We... -
RUNX1 promotes tumour metastasis by activating the Wnt/β-catenin signalling p...
Abstract Background Runt-related transcription factor 1 (RUNX1) plays the roles of an oncogene and an anti-oncogene in epithelial tumours, and abnormally elevated RUNX1 has been... -
Real-time handheld multispectral optoacoustic imaging
Multispectral optoacoustic tomography (MSOT) of functional and molecular contrast has the potential to find broad deployment in clinical practice. We have developed the first... -
Exploring differences in the use of the statin choice decision aid and diabet...
Abstract Background Shared decision making is essential to patient centered care, but can be difficult for busy clinicians to implement into practice. Tools have been developed... -
INSPECT: extending plane-casting for 6-DOF control
Abstract INSPECT is a novel interaction technique for 3D object manipulation using a rotation-only tracked touch panel. Motivated by the applicability of the technique on... -
Human laminin-111 and laminin-211 protein therapy prevents muscle disease pro...
Abstract Background Laminin-α2-related congenital muscular dystrophy (LAMA2-CMD) is a devastating genetic disease caused by mutations in the LAMA2 gene. These mutations result... -
MIA-Sig: multiplex chromatin interaction analysis by signal processing and st...
Abstract The single-molecule multiplex chromatin interaction data are generated by emerging 3D genome mapping technologies such as GAM, SPRITE, and ChIA-Drop. These datasets... -
Normalization of a conversation tool to promote shared decision making about ...
Abstract Background Shared decision making (SDM) implementation remains challenging. The factors that promote or hinder implementation of SDM tools for use during the... -
Landscape of gene fusions in epithelial cancers: seq and ye shall find
Abstract Enabled by high-throughput sequencing approaches, epithelial cancers across a range of tissue types are seen to harbor gene fusions as integral to their landscape of... -
Electronic health record tools to assist with children’s insurance coverage: ...
Abstract Background Children with health insurance have increased access to healthcare and receive higher quality care. However, despite recent initiatives expanding children’s... -
Novel Indolyl-chalcones Target Stathmin to Induce Cancer Cell Death
Efficacy of current therapies for advanced and metastatic cancers remains a challenge in clinical practice. We investigated the anti-cancer potency of 3 novel indoly-chalcones... -
DNetDB: The human disease network database based on dysfunctional regulation ...
Abstract Disease similarity study provides new insights into disease taxonomy, pathogenesis, which plays a guiding role in diagnosis and treatment. The early studies were...
