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Genetic tool for fate mapping of Oct4 (Pou5f1)-expressing cells and their pro...
Abstract Background Methods based on site-specific recombinases are widely used in studying gene activities in vivo and in vitro. In these studies, constitutively active or... -
Kinematic adaptions to induced short-term pelvic limb lameness in trotting dogs
Abstract Background Lameness due to paw injuries is common in the clinical practice. Although many studies investigated gait adaptations to diseases or injuries, mainly of the... -
Retrospective analysis in oculocutaneous albinism patients for the 2.7 kb del...
Abstract Background Oculocutaneous albinism (OCA) is an autosomal recessive disorder. A significant portion of OCA patients has been found with a single pathogenic variant... -
Saturated absorption competition microscopy
Owing to the advantage of being non-invasive in observing living samples, far-field optical microscopy is widely used in the life sciences, but the existence of the diffraction... -
Respiration activity monitoring system for any individual well of a 48-well m...
Abstract Background Small-scale micro-bioreactors have become the cultivation vessel of choice during the first steps of bioprocess development. They combine high cultivation... -
Developmental and morphological studies in Japanese medaka with ultra-high re...
We propose ultra-high resolution optical coherence tomography to study the morphological development of internal organs in medaka fish in the post-embryonic stages at micrometer... -
Sensor-based characterization of daily walking: a new paradigm in pre-frailty...
Abstract Background Frailty is a highly recognized geriatric syndrome resulting in decline in reserve across multiple physiological systems. Impaired physical function is one of... -
Synthesis of graphene oxide-quaternary ammonium nanocomposite with synergisti...
Abstract Background Bacterial infection is one of the most common complications in burn, trauma, and chronic refractory wounds and is an impediment to healing. The frequent... -
A low-cost aeroponic phenotyping system for storage root development: unravel...
Abstract Background Root and tuber crops are becoming more important for their high source of carbohydrates, next to cereals. Despite their commercial impact, there are... -
Quantitative evaluation of corneal epithelial edema after cataract surgery us...
Abstract Purpose The optical density of the cornea can be evaluated quantitatively by “densitometry” using a rotating Scheimpflug camera. Densitometry allows evaluation of... -
Impact of faculty development programme on self-efficacy, competency and atti...
Abstract Background Soon after Bhutan’s first medical university was established in 2012, Faculty Development Programmes (FDPs) were adopted for efficient delivery of... -
Influence of volatile anesthesia versus total intravenous anesthesia on chron...
Abstract Background Many patients develop chronic postsurgical pain (CPSP) after cardiac surgery, which interferes with their sleep, mood, and quality of life. Studies have... -
Modified bolster dressing with continuous suction improves skin graft surviva...
Abstract Background Skin engraftment of intraoral defects is known to be inconsistent due to mobility of the oral structure, uneven wounds, and accumulation of saliva under the... -
A novel transcription factor specifically regulates GH11 xylanase genes in Tr...
Abstract Background The filamentous fungus Trichoderma reesei is widely utilized in industry for cellulase production, but its xylanase activity must be improved to enhance the... -
Development of a web-based assessment tool that evaluates the meal situation ...
Abstract Background Children with cancer often suffer side effects from their treatment, for example nausea and vomiting, which can lead to malnutrition. If a child cannot eat... -
The genetic insulator RiboJ increases expression of insulated genes
Abstract A primary objective of synthetic biology is the construction of genetic circuits with behaviors that can be predicted based on the properties of the constituent genetic... -
Microvascular complications burden (nephropathy, retinopathy and peripheral p...
Abstract Background Microvascular complications (MC) have been claimed to increase the risk for cardiovascular disease in diabetic subjects. However, the effect of MC burden on... -
Aberrant activation of NF-κB signaling in mammary epithelium leads to abnorma...
Abstract Background Approximately 1 in 5 women diagnosed with breast cancer are considered to have in situ disease, most often termed ductal carcinoma in situ (DCIS). Though... -
Frailty in end-stage renal disease: comparing patient, caregiver, and clinici...
Abstract Background Frailty is associated with poor outcomes for patients on dialysis and is traditionally measured using tools that assess physical impairment. Alternate... -
Capturing the diversity of the human gut microbiota through culture-enriched ...
Abstract Background The human gut microbiota has been implicated in most aspects of health and disease; however, most of the bacteria in this community are considered...
