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Genetic tool for fate mapping of Oct4 (Pou5f1)-expressing cells and their pro...
Abstract Background Methods based on site-specific recombinases are widely used in studying gene activities in vivo and in vitro. In these studies, constitutively active or... -
Retrospective analysis in oculocutaneous albinism patients for the 2.7 kb del...
Abstract Background Oculocutaneous albinism (OCA) is an autosomal recessive disorder. A significant portion of OCA patients has been found with a single pathogenic variant... -
Respiration activity monitoring system for any individual well of a 48-well m...
Abstract Background Small-scale micro-bioreactors have become the cultivation vessel of choice during the first steps of bioprocess development. They combine high cultivation... -
Influence of volatile anesthesia versus total intravenous anesthesia on chron...
Abstract Background Many patients develop chronic postsurgical pain (CPSP) after cardiac surgery, which interferes with their sleep, mood, and quality of life. Studies have... -
A novel transcription factor specifically regulates GH11 xylanase genes in Tr...
Abstract Background The filamentous fungus Trichoderma reesei is widely utilized in industry for cellulase production, but its xylanase activity must be improved to enhance the... -
The genetic insulator RiboJ increases expression of insulated genes
Abstract A primary objective of synthetic biology is the construction of genetic circuits with behaviors that can be predicted based on the properties of the constituent genetic... -
Aberrant activation of NF-κB signaling in mammary epithelium leads to abnorma...
Abstract Background Approximately 1 in 5 women diagnosed with breast cancer are considered to have in situ disease, most often termed ductal carcinoma in situ (DCIS). Though... -
Capturing the diversity of the human gut microbiota through culture-enriched ...
Abstract Background The human gut microbiota has been implicated in most aspects of health and disease; however, most of the bacteria in this community are considered... -
Quinones are growth factors for the human gut microbiota
Abstract Background The human gut microbiome has been linked to numerous components of health and disease. However, approximately 25% of the bacterial species in the gut remain... -
Construction of a trifunctional cellulase and expression in Saccharomyces cer...
Abstract Background Cellulose is the most important component of lignocellulose, and its degradation requires three different types of enzymes to act synergistically. There have... -
Carotid arterial wall inflammation in peripheral artery disease is augmented ...
Abstract Background Patients with peripheral artery disease (PAD) are at increased risk of secondary events, which is exaggerated in the presence of type 2 diabetes mellitus.... -
Identification of a putative methyltransferase gene of Babesia bigemina as a ...
Abstract Background Bovine babesiosis is caused by apicomplexan pathogens of the genus Babesia such as B. bigemina and B. bovis. These tick-borne pathogens have a complex... -
Validated and longitudinally stable asthma phenotypes based on cluster analys...
Abstract Background Asthma is a disease of varying severity and differing disease mechanisms. To date, studies aimed at stratifying asthma into clinically useful phenotypes have... -
Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell in...
Abstract Background Lysyl oxidase-like 4 (LOXL4) has been found to be dysregulated in several human malignancies, including hepatocellular carcinoma (HCC). However, the role of... -
Development of a strictly regulated xylose-induced expression system in Strep...
Abstract Background Genetic tools including constitutive and inducible promoters have been developed over the last few decades for strain engineering in Streptomyces. Inducible... -
A systematic review of the clinical application of data-driven population seg...
Abstract Background Data-driven population segmentation analysis utilizes data analytics to divide a heterogeneous population into parsimonious and relatively homogenous groups... -
Identifying the effect of patient sharing on between-hospital genetic differe...
Abstract Background Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common healthcare-associated pathogens. To examine the role of inter-hospital patient... -
High-Quality draft genome sequence of the Lotus spp. microsymbiont Mesorhizob...
Abstract Mesorhizobium loti strain CJ3Sym was isolated in 1998 following transfer of the integrative and conjugative element ICEMlSymR7A, also known as the R7A symbiosis island,... -
Volumetric imaging of holographic optical traps
The holographic optical trapping technique creates arbitrary three-dimensional configurations of optical traps, each with individually specified characteristics. Holographic... -
Dynamic light sheet generation and fluorescence imaging behind turbid media
Abstract Background Light sheet microscopy became a popular tool allowing fast imaging with reduced out of focus light. However, when light penetrates turbid media such as...
