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Thermo-optic tuning and switching in SOI waveguide Fabry-Perot microcavities
Compact silicon-on-insulator (SOI) waveguide thermo-optically tunable Fabry-Perot microcavities with silicon/air Bragg mirrors are demonstrated. Quality factors of Q=4,584 are... -
s·nr: a visual analytics framework for contextual analyses of private and pub...
Abstract Background Next-Generation Sequencing (NGS) has been widely accepted as an essential tool in molecular biology. Reduced costs and automated analysis pipelines make the... -
Omalizumab in patients with severe asthma and persistent sputum eosinophilia
Abstract Omalizumab, a recombinant humanized monoclonal antibody targeting the IgE molecule, is the first biologic approved for moderate-to-severe allergic asthmatics, who... -
ISSEC: inferring contacts among protein secondary structure elements using de...
Abstract Background The formation of contacts among protein secondary structure elements (SSEs) is an important step in protein folding as it determines topology of protein... -
CellTag Indexing: genetic barcode-based sample multiplexing for single-cell g...
Abstract High-throughput single-cell assays increasingly require special consideration in experimental design, sample multiplexing, batch effect removal, and data... -
Comparing structural fingerprints using a literature-based similarity benchmark
Abstract Background The concept of molecular similarity is one of the central ideas in cheminformatics, despite the fact that it is ill-defined and rather difficult to assess... -
Applicability of RNA standards for evaluating RT-qPCR assays and platforms
Abstract The availability of diverse RT-qPCR assay formats and technologies hinder comparability of data between platforms. Reference standards to facilitate platform evaluation... -
Development of a benchmark tool for cancer centers; results from a pilot exer...
Abstract Background Differences in cancer survival exist between countries in Europe. Benchmarking of good practices can assist cancer centers to improve their services aiming... -
The NuA4 acetyltransferase and histone H4 acetylation promote replication rec...
Abstract Background Histone acetylation plays an important role in DNA replication and repair because replicating chromatin is subject to dynamic changes in its structures.... -
CIDR: Ultrafast and accurate clustering through imputation for single-cell RN...
Abstract Most existing dimensionality reduction and clustering packages for single-cell RNA-seq (scRNA-seq) data deal with dropouts by heavy modeling and computational... -
Complex microseismic activity and depth-dependent stress field changes in Wak...
Abstract We examined the spatial relationship between seismicity and upper crustal structure in the Wakayama region, northwestern Kii Peninsula, Japan, by investigating... -
RUNX1 promotes tumour metastasis by activating the Wnt/β-catenin signalling p...
Abstract Background Runt-related transcription factor 1 (RUNX1) plays the roles of an oncogene and an anti-oncogene in epithelial tumours, and abnormally elevated RUNX1 has been... -
High-throughput PCR assay design for targeted resequencing using primerXL
Abstract Background Although the sequencing landscape is rapidly evolving and sequencing costs are continuously decreasing, whole genome sequencing is still too expensive for... -
How to improve patient education on deep brain stimulation in Parkinson’s dis...
Abstract Background The introduction of deep brain stimulation (DBS) about 25 years ago provided one of the major breakthroughs in the treatment of Parkinson’s disease (PD).... -
INSPECT: extending plane-casting for 6-DOF control
Abstract INSPECT is a novel interaction technique for 3D object manipulation using a rotation-only tracked touch panel. Motivated by the applicability of the technique on... -
Human laminin-111 and laminin-211 protein therapy prevents muscle disease pro...
Abstract Background Laminin-α2-related congenital muscular dystrophy (LAMA2-CMD) is a devastating genetic disease caused by mutations in the LAMA2 gene. These mutations result... -
Brownian fluctuations of an optically rotated nanorod
Gold nanorods can be optically trapped in aqueous solution and forced to rotate at kilohertz rates by circularly polarized laser light. This enables detailed investigations of... -
Effective star tracking method based on optical flow analysis for star trackers
Benefiting from rapid development of imaging sensor technology, modern optical technology, and a high-speed computing chip, the star tracker’s accuracy, dynamic performance, and... -
MIA-Sig: multiplex chromatin interaction analysis by signal processing and st...
Abstract The single-molecule multiplex chromatin interaction data are generated by emerging 3D genome mapping technologies such as GAM, SPRITE, and ChIA-Drop. These datasets... -
Resolution limits to object tracking with subpixel accuracy
Subpixel methods increase the accuracy and efficiency of image detectors, processing units, and algorithms and provide very cost-effective systems for object tracking. Published...
