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Dexketoprofen/tramadol 25 mg/75 mg: randomised double-blind trial in moderate...
Abstract Background Dexketoprofen trometamol plus tramadol hydrochloride is a new oral combination of two analgesics, which have different mechanisms of action for the treatment... -
Periostin involved in the activated hepatic stellate cells-induced progressio...
Abstract Background Incomplete thermal ablation may induce invasiveness of hepatocellular carcinoma (HCC). Here, we investigated whether activated hepatic stellate cells (HSCs)... -
Effect of hCMSCs and liraglutide combination in ALI through cAMP/PKAc/β-caten...
Abstract Background ALI/ARDS is the major cause of acute respiratory failure in critically ill patients. As human chorionic villi-derived MSCs (hCMSCs) could attenuate ALI in... -
Study of serious adverse drug reactions using FDA-approved drug labeling and ...
Abstract Background Adverse Drug Reactions (ADRs) are of great public health concern. FDA-approved drug labeling summarizes ADRs of a drug product mainly in three sections,... -
The role of antifungals in the management of patients with severe asthma
Abstract In patients with asthma, the inhalation of elevated amounts of fungal spores and hyphae may precipitate the onset of asthma or worsen control to the extent of being... -
Prevalence and antimicrobial susceptibility profiles of Staphylococcus aureus...
Abstract Background Methicillin resistant Staphylococcus aureus (MRSA) nasal carriage is a potential niche for spread and a risk factor for subsequent infections. Despite the... -
Long-term overall survival and prognostic score predicting survival: the IMPA...
Abstract Background In 2007, we initiated IMPACT, a precision medicine program for patients referred for participation in early-phase clinical trials. We assessed the... -
Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mic...
Abstract Background Nonalcoholic fatty liver disease is one of the most common liver diseases in the world and is a typical hepatic manifestation of metabolic syndrome which is... -
Prevalence and profile of adverse drug reactions in high-risk pregnancy: a co...
Abstract Background Commonly used drugs in pregnant women include antihypertensives, hypoglycemic agents, analgesics, antimicrobials, antiemetics and antispasmodics but the use... -
Suppression of endothelial cell migration by tumor associated macrophage-deri...
Abstract Objective To study the mechanism by which epithelial ovarian cancer (EOC)-derived exosomes restore the migration of endothelial cells that is suppressed by TAM-derived... -
Food systems transformations, ultra-processed food markets and the nutrition ...
Abstract Background Attracted by their high economic growth rates, young and growing populations, and increasingly open markets, transnational food and beverage corporations... -
Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrat...
Abstract Background Zyflamend, a blend of herbal extracts, effectively inhibits tumor growth using preclinical models of castrate-resistant prostate cancer mediated in part by... -
Reduction in clinically important deterioration in chronic obstructive pulmon...
Abstract Background ‘Clinically important deterioration’ (CID) is a composite endpoint measuring worsening of the key clinical features of chronic obstructive pulmonary disease... -
Lagovirus europeus GI.2 (rabbit hemorrhagic disease virus 2) infection in cap...
Abstract Background Rabbit hemorrhagic disease virus (RHDV, Lagovirus europeus GI.1) induces a contagious and highly lethal hemorrhagic disease in rabbits. In 2010 a new... -
iCAGES: integrated CAncer GEnome Score for comprehensively prioritizing drive...
Abstract Cancer results from the acquisition of somatic driver mutations. Several computational tools can predict driver genes from population-scale genomic data, but tools for... -
Replication competence of virions induced from CD4+ lymphocytes latently infe...
Abstract Latently infected CD4 lymphocytes preclude cure of HIV infection, even with the most effective antiretroviral therapy. The replication competent latent HIV reservoir... -
The median effective dose (ED50) of cis-Atracurium for laryngeal mask airway ...
Abstract Background In clinical practice, the laryngeal mask airway is an easy-to-use supraglottic airway device. However, the cis-atracurium dosage for laryngeal mask insertion... -
Rare TBK1 variants in patients with frontotemporal dementia and amyotrophic l...
Abstract Background The TANK-Binding Kinase 1 (TBK1) gene has recently been identified as the third or fourth most frequent cause of frontotemporal dementia (FTD) and... -
Epistasis analysis uncovers hidden antibiotic resistance-associated fitness c...
Abstract Background Fitness costs imposed on bacteria by antibiotic resistance mechanisms are believed to hamper their dissemination. The scale of these costs is highly... -
Phenotypic and genotypic monitoring of Schistosoma mansoni in Tanzanian schoo...
Abstract Background Schistosoma mansoni is a parasite of profound medical importance. Current control focusses on mass praziquantel (PZQ) treatment of populations in endemic...
