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Retrospective analysis in oculocutaneous albinism patients for the 2.7 kb del...
Abstract Background Oculocutaneous albinism (OCA) is an autosomal recessive disorder. A significant portion of OCA patients has been found with a single pathogenic variant... -
Periostin involved in the activated hepatic stellate cells-induced progressio...
Abstract Background Incomplete thermal ablation may induce invasiveness of hepatocellular carcinoma (HCC). Here, we investigated whether activated hepatic stellate cells (HSCs)... -
Distribution of nickel and chromium containing particles from tattoo needle w...
Abstract Background Allergic reactions to tattoos are amongst the most common side effects occurring with this permanent deposition of pigments into the dermal skin layer. The... -
TSS seq based core promoter architecture in blood feeding Tsetse fly (Glossin...
Abstract Background Transcription initiation regulation is mediated by sequence-specific interactions between DNA-binding proteins (transcription factors) and cis-elements,... -
Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype ...
Abstract Background The use of immunodeficient mice transplanted with human hematopoietic stem cells is an accepted approach to study human-specific infectious diseases such as... -
MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy an...
Abstract Background In diabetes mellitus the morbidity and mortality of cardiovascular disease is increased and represents an important independent mechanism by which heart... -
A novel nonsense mutation in the tyrosinase gene is related to the albinism i...
Abstract Background Oculocutaneous Albinism (OCA) is an autosomal recessive inherited condition that affects the pigmentation of eyes, hair and skin. The OCA phenotype may be... -
Identification and validation of a Schistosoma japonicum U6 promoter
Abstract Background RNA polymerase III promoters have been widely used to express short hairpin-RNA (shRNA), microRNA (miRNA), and small guide RNA (sgRNA) in gene functional... -
Development and validation of a novel PCR-RFLP based method for the detection...
Abstract Background Leber’s Hereditary Optic Neuropathy (LHON; MIM 535000) is one of the most commonly inherited optic neuropathies and it results in significant visual... -
Dipeptidyl peptidase-4 is highly expressed in bronchial epithelial cells of u...
Abstract Background Type 2 helper T-cell cytokines including IL-13 play a central role in the pathogenesis of bronchial asthma (BA). During the course of our research, our... -
The source of circulating selenoprotein S and its association with type 2 dia...
Abstract Background Selenoprotein S (SelS) is a transmembrane protein that is expressed in the liver, skeletal muscle, adipose tissue, pancreatic islets, kidney, and blood... -
Virulence factor RNA transcript expression in the Leishmania Viannia subgenus...
Abstract Background Leishmania RNA virus-1 (LRV1) is a double-stranded RNA virus identified in 20–25% of Viannia—species endemic to Latin America, and is believed to accelerate... -
Overexpression of MALT1-A20-NF-κB in adult B-cell acute lymphoblastic leukemia
Abstract Background A20 is a dual inhibitor of NF-κB activation and apoptosis in the tumor necrosis factor receptor 1 signaling pathway, and both are related to tumorigenesis.... -
Involvement of Hdac3-mediated inhibition of microRNA cluster 17-92 in broncho...
Abstract Background The incidence of bronchopulmonary dysplasia (BPD), a chronic lung disease of newborns, has been paradoxically rising despite medical advances. Histone... -
Comparison of two methods of collecting healthcare usage data in chiropractic...
Abstract Background The use of patient-reported questionnaires to collect information on costs associated with routine healthcare services, such as chiropractic, represents a... -
Evidence of cAMP involvement in cellobiohydrolase expression and secretion by...
Abstract Background The signaling second messenger cyclic AMP (cAMP) regulates many aspects of cellular function in all organisms. Previous studies have suggested a role for... -
Evaluating the efficacy of dexamethasone in the treatment of patients with pe...
Abstract Background Although much has evolved in our understanding of the pathogenesis and factors affecting outcome of patients with acute respiratory distress syndrome (ARDS),... -
Bacillus subtilis 5′-nucleotidases with various functions and substrate speci...
Abstract Background In Escherichia coli, nagD, yrfG, yjjG, yieH, yigL, surE, and yfbR encode 5′-nucleotidases that hydrolyze the phosphate group of 5′-nucleotides. In Bacillus... -
Post renal transplant anemia: severity, causes and their association with gra...
Abstract Background Post transplantation anemia (PTA) is common among kidney transplant patients. PTA is associated with increased graft loss and in most studies with increased... -
Quorum sensing of Streptococcus mutans is activated by Aggregatibacter actino...
Abstract Background The oral cavity is inhabited by complex microbial communities forming biofilms that can cause caries and periodontitis. Cell-cell communication might play an...
