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Relationship between age and bronchodilator response at diagnosis in adult-on...
Abstract Background Possible variation in bronchodilator response (BDR) according to age at the diagnosis of adult-onset asthma is unknown. Our aim was to assess if BDR in FEV1... -
The role of antifungals in the management of patients with severe asthma
Abstract In patients with asthma, the inhalation of elevated amounts of fungal spores and hyphae may precipitate the onset of asthma or worsen control to the extent of being... -
Oxidative stress enhances the expression of IL-33 in human airway epithelial ...
Abstract Background Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, and its possible involvement in the pathophysiology of COPD and viral-induced... -
Status of metered dose inhaler technique among patients with asthma and its e...
Abstract Objective In Asthma management, poor handling of inhalation devices and wrong inhalation technique are associated with decreased medication delivery and poor disease... -
Impaired type I interferon regulation in the blood transcriptome of recurrent...
Abstract Background Asthma exacerbations are an important cause of morbidity in asthma. Respiratory infections are often involved in asthma exacerbations in both children and... -
Effect of tiotropium on night-time awakening and daily rescue medication use ...
Abstract Background Several small studies found night-time awakenings due to COPD symptoms were associated with decreased health status. In this study, night-time awakenings in... -
Predictors of clinical response to extrafine and non-extrafine particle inhal...
Abstract We performed a post-hoc analysis of the OLiVIA-study investigating whether current and ex-smoking asthmatics with small airways dysfunction (SAD) show a better response... -
Determinants and impact of suboptimal asthma control in Europe: The INTERNATI...
Abstract Background According to the Global Initiative of Asthma, the aim of asthma treatment is to gain and maintain control. In the INTERNATIONAL CROSS-SECTIONAL AND... -
Severe asthma features in children: a case–control online survey
Abstract Background Very few studies have explored the distinguishing features of severe asthma in childhood in Europe, and only one study was conducted in Southern Europe. The... -
Assessment of levels of asthma control among adult patients with asthma at Ch...
Abstract Background The management of the reversible airways obstruction forms the cornerstone of quality asthma management. The aim of this study was to assess the level of... -
Mechanical Ventilation Augments Poly(I:C)-Induced Lung Injury via a WISP1-Int...
Abstract Mechanical ventilation can improve hypoxemia, but can also cause the so-called ventilator-induced lung injury (VILI). Polyinosinic:polycytidylic acid (poly(I:C)), an... -
Effects of hypoxia and hyperoxia on the differential expression of VEGF-A iso...
Abstract Dysregulation of VEGF-A bioavailability has been implicated in the development of lung injury/fibrosis, exemplified by Idiopathic Pulmonary Fibrosis (IPF). VEGF-A is a... -
Use of antibiotics and asthma medication for acute lower respiratory tract in...
Abstract Background Antibiotics are overused in patients with acute lower respiratory tract infections (ALRTIs), but less is known about their use in patients with asthma, or... -
Risk factors for poor asthma control and impaired quality of life in a Caribb...
Objective: Asthma, a major cause of disability and reduced quality of life, has a high global prevalence and burden of death. Despite the propitious guidelines, a substantial... -
Independent associations between arterial bicarbonate, apnea severity and hyp...
Abstract Background Obstructive sleep apnea is characterized by intermittent hypoxia and hypercapnia. CO2 production, transport and elimination are influenced by the carbonic...
