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MRI of trunk muscles and motor and respiratory function in patients with myot...
Abstract Background Myotonic Dystrophy 1 (DM1) causes progressive myopathy of extremity muscles. DM1 may also affect muscles of the trunk. The aim of this study was to... -
Prevalence and characteristics of older adults with a persistent death wish w...
Abstract Background Some older persons develop a persistent death wish without being severely ill, often referred to as “completed life” or “tiredness of life”. In the... -
Comparative utility of frailty to a general prognostic score in identifying p...
Abstract Background Current guidelines recommend considering life expectancy before aortic valve replacement (AVR). We compared the performance of a general mortality index, the... -
Influence of volatile anesthesia versus total intravenous anesthesia on chron...
Abstract Background Many patients develop chronic postsurgical pain (CPSP) after cardiac surgery, which interferes with their sleep, mood, and quality of life. Studies have... -
Pervasive read-through transcription of T-DNAs is frequent in tobacco BY-2 ce...
Abstract Background Plant transformation via Agrobacterium tumefaciens is characterized by integration of commonly low number of T-DNAs at random positions in the genome. When... -
Development of an infant feeding core outcome set for childhood obesity inter...
Abstract Background Childhood obesity is a significant public health challenge that affects approximately one in five children worldwide. Infant feeding practices are implicated... -
Factors influencing decision regret regarding placement of a PEG among substi...
Abstract Background A tube feeding decision aid designed at the Ottawa Health Research Institute was specifically created for substitute decision-makers who must decide whether... -
Status of metered dose inhaler technique among patients with asthma and its e...
Abstract Objective In Asthma management, poor handling of inhalation devices and wrong inhalation technique are associated with decreased medication delivery and poor disease... -
A transgenerational role of the germline nuclear RNAi pathway in repressing h...
Abstract Background Environmental stress-induced transgenerational epigenetic effects have been observed in various model organisms and human. The capacity and mechanism of such... -
Chronic pain after groin hernia repair: pain characteristics and impact on qu...
Abstract Background Chronic postsurgical pain (CPSP) after hernia repair research has mainly relied on unconfirmed self-reporting. We aimed to describe confirmed CPSP incidence,... -
Protocol for the Wessex AsThma CoHort of difficult asthma (WATCH): a pragmati...
Abstract Background Asthma is now widely recognised to be a heterogeneous disease. The last two decades have seen the identification of a number of biological targets and... -
Epigenetic and non-epigenetic mode of SIRT1 action during oocyte meiosis prog...
Abstract Background SIRT1 histone deacetylase acts on many epigenetic and non-epigenetic targets. It is thought that SIRT1 is involved in oocyte maturation; therefore, the... -
Distinct immune responses of juvenile and adult oysters (Crassostrea gigas) t...
Abstract Since 2008, massive mortality events of Pacific oysters (Crassostrea gigas) have been reported worldwide and these disease events are often associated with Ostreid... -
Interactions between ALDH2 rs671 polymorphism and lifestyle behaviors on coro...
Abstract Background Both aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism and lifestyle behaviors are involved in coronary artery disease (CAD), while the interaction between... -
Regulation of platelet-activating factor-induced interleukin-8 expression by ...
Abstract Background Platelet-activating factor (PAF) is a potent lipid mediator whose involvement in the onset and progression of atherosclerosis is mediated by, among others,... -
Using the life grid interview technique in STEM education research
Abstract Background Qualitative interviewing is a common tool that has been utilized by science, technology, engineering, and mathematics (STEM) education researchers to explore... -
Ketamine-induced apoptosis in the mouse cerebral cortex follows similar chara...
Abstract The effects of general anesthetics on inducing neuronal apoptosis during early brain development are well-documented. However, since physiological apoptosis also occurs... -
Polygenic risk for coronary heart disease acts through atherosclerosis in typ...
Abstract Background Type 2 diabetes increases the risk of coronary heart disease (CHD), yet the mechanisms involved remain poorly described. Polygenic risk scores (PRS) provide... -
Identification and validation of a Schistosoma japonicum U6 promoter
Abstract Background RNA polymerase III promoters have been widely used to express short hairpin-RNA (shRNA), microRNA (miRNA), and small guide RNA (sgRNA) in gene functional... -
Enhancers reside in a unique epigenetic environment during early zebrafish de...
Abstract Background Enhancers, not promoters, are the most dynamic in their DNA methylation status throughout development and differentiation. Generally speaking, enhancers that...
