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EWS and FUS bind a subset of transcribed genes encoding proteins enriched in ...
Abstract Background FUS (TLS) and EWS (EWSR1) belong to the FET-protein family of RNA and DNA binding proteins. FUS and EWS are structurally and functionally related and... -
Pervasive read-through transcription of T-DNAs is frequent in tobacco BY-2 ce...
Abstract Background Plant transformation via Agrobacterium tumefaciens is characterized by integration of commonly low number of T-DNAs at random positions in the genome. When... -
A functional connectome: regulation of Wnt/TCF-dependent transcription by pai...
Abstract Background Wnt/β-catenin signaling is often portrayed as a simple pathway that is initiated by Wnt ligand at the cell surface leading, via linear series of interactions... -
Characterization of novel Bovine Leukemia Virus (BLV) antisense transcripts b...
Abstract Background Bovine Leukemia Virus (BLV) is a deltaretrovirus closely related to the Human T cell leukemia virus-1 (HTLV-1). Cattle are the natural host of BLV where it... -
Regulation of platelet-activating factor-induced interleukin-8 expression by ...
Abstract Background Platelet-activating factor (PAF) is a potent lipid mediator whose involvement in the onset and progression of atherosclerosis is mediated by, among others,... -
Identification and validation of a Schistosoma japonicum U6 promoter
Abstract Background RNA polymerase III promoters have been widely used to express short hairpin-RNA (shRNA), microRNA (miRNA), and small guide RNA (sgRNA) in gene functional... -
Signal transducer and activator of transcription STAT5 is recruited to c-Myc ...
Abstract Background c-Myc has been proposed as a putative target gene of signal transducer and activator of transcription 5 (STAT5). No functional STAT5 binding site has been... -
Helveticoside is a biologically active component of the seed extract of Descu...
Abstract Background Although the pharmacological activities of the seed extract of Descurainia sophia have been proven to be useful against cough, asthma, and edema, the... -
Characteristics of functional enrichment and gene expression level of human p...
Abstract Background Transcriptional target genes show functional enrichment of genes. However, how many and how significantly transcriptional target genes include functional... -
Architecture of divergent flagellar promoters controlled by CtrA in Rhodobact...
Abstract Background Rhodobacter sphaeroides has two sets of flagellar genes, fla1 and fla2, that are responsible for the synthesis of two different flagellar structures. The... -
RNA polymerase II depletion promotes transcription of alternative mRNA species
Abstract Background Cells respond to numerous internal and external stresses, such as heat, cold, oxidative stress, DNA damage, and osmotic pressure changes. In most cases, the... -
Intraflagellar transport proteins are involved in thrombocyte filopodia forma...
Intraflagellar transport (IFT) proteins are vital for the genesis and maintenance of cilia. Our identification of ift122 transcripts in zebrafish thrombocytes that lack primary... -
Transcriptional activation of USP16 gene expression by NFκB signaling
Abstract Ubiquitin Specific Peptidase 16 (USP16) has been reported to contribute to somatic stem-cell defects in Down syndrome. However, how this gene being regulated is largely... -
A CLCA regulatory protein present in the chemosensory cilia of olfactory sens...
Abstract Background CLCA is a family of metalloproteases that regulate Ca2+-activated Cl− fluxes in epithelial tissues. In HEK293 cells, CLCA1 promotes membrane expression of an... -
Coordinated inhibition of C/EBP by Tribbles in multiple tissues is essential ...
Abstract Background Tribbles proteins are conserved pseudokinases that function to control kinase signalling and transcription in diverse biological processes. Abnormal function... -
The HDAC6/APOBEC3G complex regulates HIV-1 infectiveness by inducing Vif auto...
Abstract Background Human immunodeficiency virus type 1 (HIV-1) has evolved a complex strategy to overcome the immune barriers it encounters throughout an organism thanks to its... -
In-vitro function of upstream visfatin polymorphisms that are associated with...
Abstract Background Visfatin is an adipokine associated with glucose and lipid metabolism. We previously reported two visfatin upstream single nucleotide polymorphisms (SNPs),... -
eEF1Bγ binds the Che-1 and TP53 gene promoters and their transcripts
Abstract Background We have previously shown that the eukaryotic elongation factor subunit 1B gamma (eEF1Bγ) interacts with the RNA polymerase II (pol II) alpha-like subunit “C”... -
Activation of the NLRP3 inflammasome in lipopolysaccharide-induced mouse fati...
Abstract Background The NLRP3 inflammasome (NOD-like receptor family, pyrin domain containing 3) is an intracellular protein complex that plays an important role in innate... -
Overexpression of PaNAC03, a stress induced NAC gene family transcription fac...
Abstract Background The NAC family of transcription factors is one of the largest gene families of transcription factors in plants and the conifer NAC gene family is at least as...
