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Helios + Regulatory T cell frequencies are correlated with control of viral r...
Abstract Background The acute phase of HIV infection is characterized by massive depletion of CD4 T cells, high viral plasma levels and pronounced systemic immune activation.... -
Climate factors driven typhus group rickettsiosis incidence dynamics in Xishu...
Abstract Background Typhus group rickettsiosis (TGR), which is a neglected vector-borne infectious disease, including epidemic typhus and endemic typhus. We explored the lag... -
Gene expression prediction using low-rank matrix completion
Abstract Background An exponential growth of high-throughput biological information and data has occurred in the past decade, supported by technologies, such as microarrays and... -
How effective are digital interventions in increasing flu vaccination amongst...
Abstract Background Pregnant women and their unborn babies are at increased risk of complications as a result of flu, yet uptake of the flu vaccination in the UK remains low.... -
Sublingual microcirculation does not reflect red blood cell transfusion thres...
Abstract Purpose Hemoglobin (Hb) transfusion thresholds are established in intensive care units. A restrictive transfusion threshold (Hb 70–75 g/l) is recommended in septic... -
Detection of lipoarabinomannan (LAM) in urine is an independent predictor of ...
Abstract Background Simple immune capture assays that detect mycobacterial lipoarabinomannan (LAM) antigen in urine are promising new tools for the diagnosis of HIV-associated... -
Combined interventions to reduce HIV incidence in KwaZulu-Natal: a modelling ...
Abstract Background Combined prevention interventions, including early antiretroviral therapy initiation, may substantially reduce HIV incidence in hyperendemic settings. Our... -
Relation of multi-marker panel to incident chronic kidney disease and rapid k...
Abstract Background Few investigations have evaluated the incremental usefulness of multiple biomarkers representing varying physiological pathways for predicting risk of renal... -
Development of a Core Outcome Set for Studies on Obesity in Pregnant Patients...
Abstract Background Maternal obesity is a risk factor for adverse maternal, fetal, and neonatal events. Numerous clinical trials are currently exploring the effectiveness of... -
Use of biologically-based complementary medicine in breast and gynecological ...
Abstract Background Biologically-based complementary medicines (BB-CAM) including herbs and nutritional supplements are frequently taken by breast- and gynecological cancer... -
Helicobacter pylori infection as a risk factor for serum bilirubin change and...
Abstract Background Helicobacter pylori infection is associated with several extragastric conditions including dyslipidemia and metabolic syndrome. This study aimed to... -
Outcomes of community-based differentiated models of multi-month dispensing o...
Abstract Background Current World Health Organization (WHO) guidelines recommend early initiation of HIV positive patients on antiretroviral therapy (ART) irrespective of their... -
Mathematical models for devising the optimal Ebola virus disease eradication
Abstract Background The 2014â 2015 epidemic of Ebola virus disease (EVD) in West Africa defines an unprecedented health threat for human. Methods We construct a mathematical... -
Assessment of the safety of antimalarial drug use during early pregnancy (ASA...
Abstract Background A major unresolved safety concern for malaria case management is the use of artemisinin combination therapies (ACTs) in the first trimester of pregnancy.... -
Varicella zoster virus-associated morbidity and mortality in Africa â a sys...
Abstract Background Varicella zoster virus (VZV) causes varicella and herpes zoster. These vaccine preventable diseases are common globally. Most available data on VZV... -
Factors associated with loss-to-follow-up of HIV-positive mothers and their i...
Abstract Background In Malawi, loss to follow-up (LTFU) of HIV-positive pregnant and postpartum women on Option B+ regimen greatly contributes to sub-optimal retention,... -
Utilization of dual contraception method among reproductive age women on anti...
Abstract Background Sexually transmitted infections are highly prevalent among pregnant women in Africa. Among the incidence of HIV infection in children, 90% of the infection... -
Serum bicarbonate concentration and the risk of cardiovascular disease and de...
Abstract Background Serum bicarbonate is associated with mortality, heart failure (HF) and progression of renal failure in studies of healthy people and patients with chronic... -
A randomized, 29-day, dose-ranging, efficacy and safety study of daprodustat,...
Abstract Background Daprodustat is a hypoxia-inducible factor-prolyl hydroxylase inhibitor currently being investigated as a treatment for anemia of chronic kidney disease (CKD)... -
Scalable non-negative matrix tri-factorization
Abstract Background Matrix factorization is a well established pattern discovery tool that has seen numerous applications in biomedical data analytics, such as gene expression...
