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Saliva exosomes-derived UBE2O mRNA promotes angiogenesis in cutaneous wounds ...
Abstract Background Enhancing angiogenesis is critical for accelerating wound healing. Application of different types of exosomes (Exos) to promote angiogenesis represents a... -
EWS and FUS bind a subset of transcribed genes encoding proteins enriched in ...
Abstract Background FUS (TLS) and EWS (EWSR1) belong to the FET-protein family of RNA and DNA binding proteins. FUS and EWS are structurally and functionally related and... -
Pervasive read-through transcription of T-DNAs is frequent in tobacco BY-2 ce...
Abstract Background Plant transformation via Agrobacterium tumefaciens is characterized by integration of commonly low number of T-DNAs at random positions in the genome. When... -
Subunits of human condensins are potential therapeutic targets for cancers
Abstract The main role of condensins is to regulate chromosome condensation and segregation during cell cycles. Recently, it has been suggested in the literatures that subunits... -
RNA helicase p68 deploys β-catenin in regulating RelA/p65 gene expression: im...
Abstract Background RelA/p65 a crucial member of NF-κB signaling pathway plays diverse role in mediating oncogenesis. Limited knowledge prevails on the mechanistic insights of... -
Dietary intake is associated with respiratory health outcomes and DNA methyla...
Abstract Background Asthma is an increasingly common chronic disease among children, and data point toward a complex mechanism involving genetic, environmental and epigenetic... -
Structural alteration of DNA induced by viral protein R of HIV-1 triggers the...
Abstract Background Viral protein R (Vpr) is an accessory protein of HIV-1, which is potentially involved in the infection of macrophages and the induction of the... -
Characterization of novel Bovine Leukemia Virus (BLV) antisense transcripts b...
Abstract Background Bovine Leukemia Virus (BLV) is a deltaretrovirus closely related to the Human T cell leukemia virus-1 (HTLV-1). Cattle are the natural host of BLV where it... -
Differential proteomic analysis of virus-enriched fractions obtained from pla...
Abstract Background Dengue is the most widespread mosquito-borne viral disease of public health concern. In some patients, endothelial cell and platelet dysfunction lead to... -
Development of a new promoter to avoid the silencing of genes in the producti...
Abstract Background The production of recombinant proteins in mammalian cell lines is one of the most important areas in biopharmaceutical industry. Viral transcriptional... -
Regulation of platelet-activating factor-induced interleukin-8 expression by ...
Abstract Background Platelet-activating factor (PAF) is a potent lipid mediator whose involvement in the onset and progression of atherosclerosis is mediated by, among others,... -
Identification and validation of a Schistosoma japonicum U6 promoter
Abstract Background RNA polymerase III promoters have been widely used to express short hairpin-RNA (shRNA), microRNA (miRNA), and small guide RNA (sgRNA) in gene functional... -
Signal transducer and activator of transcription STAT5 is recruited to c-Myc ...
Abstract Background c-Myc has been proposed as a putative target gene of signal transducer and activator of transcription 5 (STAT5). No functional STAT5 binding site has been... -
Characteristics of functional enrichment and gene expression level of human p...
Abstract Background Transcriptional target genes show functional enrichment of genes. However, how many and how significantly transcriptional target genes include functional... -
RNA polymerase II depletion promotes transcription of alternative mRNA species
Abstract Background Cells respond to numerous internal and external stresses, such as heat, cold, oxidative stress, DNA damage, and osmotic pressure changes. In most cases, the... -
Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeuti...
Abstract Background The Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) outbreak originating in Wuhan, China, has raised global health concerns and the... -
Fibrinolysis protease receptors promote activation of astrocytes to express p...
Abstract Background Astrocytes contribute to the crosstalk that generates chronic neuro-inflammation in neurological diseases; however, compared with microglia, astrocytes... -
Transcriptional activation of USP16 gene expression by NFκB signaling
Abstract Ubiquitin Specific Peptidase 16 (USP16) has been reported to contribute to somatic stem-cell defects in Down syndrome. However, how this gene being regulated is largely... -
A CLCA regulatory protein present in the chemosensory cilia of olfactory sens...
Abstract Background CLCA is a family of metalloproteases that regulate Ca2+-activated Cl− fluxes in epithelial tissues. In HEK293 cells, CLCA1 promotes membrane expression of an... -
Regulation of platelet-activating factor-mediated interleukin-6 promoter acti...
Abstract Background An underlying state of inflammation is thought to be an important cause of cardiovascular disease. Among cells involved in the early steps of...
