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New Insights into the Activation of Escherichia coli Tyrosine Kinase Revealed...
Escherichia coli tyrosine kinase (Etk) regulates the export of pathogenic capsular polysaccharide (CPS) by intermolecularly autophosphorylating its C-terminal tyrosine cluster.... -
Studies Directed to the Total Synthesis of ET 743 and Analogues Thereof: An ...
In model studies directed to the total synthesis of Et743, a strategic S−C bond formation in systems 26 and 27 was demonstrated. It was further shown that Pictet−Spengler... -
Total Synthesis of Grandisine D
Total synthesis of grandisine D (5) was achieved by a Brønsted acid mediated Morita−Baylis−Hillman (MBH) ring-closure reaction and stereoselective aldol condensation with... -
Stress-Induced Chemical Detection Using Flexible Metal−Organic Frameworks
In this work we demonstrate the concept of stress-induced chemical detection using metal−organic frameworks (MOFs) by integrating a thin film of the MOF HKUST-1 with a... -
Brevisamide: An Unprecedented Monocyclic Ether Alkaloid from the Dinoflagella...
The dinoflagellate Karenia brevis is known for the production of brevetoxins, a family of polycyclic ether toxins, as well as their antagonist brevenal. Further examination of... -
Enantioselective Aza-Darzens Reaction Catalyzed by A Chiral Phosphoric Acid
Aza-Darzens reaction of ethyl diazoacetate with aldimines, derived from phenyl glyoxal, furnished cis-aziridine carboxylates with excellent enantioselectivities by means of a... -
Nonconjugated Red-Emitting Dendrimers with p-Type and/or n-Type Peripheries
Dendron-encapsulated materials having a benzo[c][1,2,5]thiadiazole-based red-emitting core and p-type and/or n-type peripheries were synthesized. Intra- and intermolecular... -
Catalytic C-O Bond Cleavage of 2-Aryloxy-1-arylethanols and Its Application t...
A ruthenium-catalyzed, redox neutral C−O bond cleavage of 2-aryloxy-1-arylethanols was developed that yields cleavage products in 62−98% isolated yield. This reaction is... -
Chirality Transfer from Carbon to Nitrogen to Carbon via Cyclic Ammonium Ylides
Cyclic ammonium salts 2 were prepared by diastereoselective quaternization of nitrogen in the corresponding proline or threonine derivatives. Upon treatment with base, salts 2... -
Enantioselective Total Synthesis of (+)-Obtusenyne
A total synthesis of the laurencia metabolite (+)-obtusenyne has been completed. The key steps include a Sharpless kinetic resolution and an asymmetric glycolate alkylation to... -
Indium Tin Oxide Nanoparticles with Compositionally Tunable Surface Plasmon R...
Here we report the synthesis of conducting indium tin oxide (ITO) nanoparticles (NPs) and their surface plasmon resonance (SPR) properties. The SPR peaks of the ITO NPs can be... -
The Lithium−Ene Cyclization and the Purported Carbanion-Induced Ene Cyclization
The Lithium−Ene Cyclization and the Purported Carbanion-Induced Ene Cyclization -
The Total Synthesis of Eleutherobin
The total synthesis of the title compound (1), starting with (R)-(−)-α-phellandrene (6), has been accomplished. The synthesis rigorously proves the relative stereochemical... -
Benzyl Protection of Phenols under Neutral Conditions: Palladium-Catalyzed Be...
Benzyl protection of phenols under neutral conditions was achieved by using a Pd(η3-C3H5)Cp–DPEphos catalyst. The palladium catalyst efficiently converted aryl benzyl carbonates... -
Wacker-Type Oxidation of Alkynes into 1,2-Diketones Using Molecular Oxygen
An intriguing new Wacker-type oxidation of alkynes catalyzed by PdBr2 and CuBr2 is described, which opens an efficient access to 1,2-diketones using molecular oxygen. Under the... -
Direct Electrochemical Regeneration of Monooxygenase Subunits for Biocatalyti...
We report the first example of direct electrochemical regeneration of a flavin-dependent monooxygenase for asymmetric epoxidation catalysis. It is shown that electrochemical... -
Helical Transfer through Nonlocal Interactions
A pair of chiral bola-type enantiomers, ll-12PyBr and dd-12PyBr, was synthesized. They can cause physical gels in pure water. Sol−gel transcriptions were carried out to control... -
Enantioselective Total Syntheses of Nankakurines A and B: Confirmation of Str...
Total syntheses of (+)-nankakurine A (2) and (+)-nankakurine B (3) were accomplished by a sequence that employs an intramolecular dipolar cycloaddition of an azomethine imine... -
Photoswitching in Azafullerene Encapsulated Single-Walled Carbon Nanotube FET...
The photoinduced electrical transport properties of C59N@SWNTs are investigated by assembling them into FET devices. Our findings demonstrate that azafullerene molecules inside... -
Structural Transformation due to Co-Host Inclusion in Ionic Clathrate Hydrates
The present findings on the co-host role in restructuring the host water framework might provide important information on tuning the cage dimensions via lattice distortion and...
