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Evidence of cAMP involvement in cellobiohydrolase expression and secretion by...
Abstract Background The signaling second messenger cyclic AMP (cAMP) regulates many aspects of cellular function in all organisms. Previous studies have suggested a role for... -
Evaluating the efficacy of dexamethasone in the treatment of patients with pe...
Abstract Background Although much has evolved in our understanding of the pathogenesis and factors affecting outcome of patients with acute respiratory distress syndrome (ARDS),... -
Baseline white blood cell count-to-apolipoprotein A1 ratio as a novel predict...
Abstract Background Previous studies suggested that baseline white blood cell count and apolipoprotein A1 levels were associated with clinical outcomes in patients with coronary... -
Skin rash following Administration of Apalutamide in Japanese patients with A...
Abstract Background A higher incidence of apalutamide-related skin rash has been observed in Japanese patients with prostate cancer (PC). Methods This integrated analysis of... -
Glossogyne tenuifolia (Hsiang-ju) extract suppresses T cell activation by inh...
Abstract Background Glossogyne tenuifolia (GT) (Hsiang-ju) is a Chinese herbal medicine previously exhibited an anti-inflammatory activity. This study aimed to investigate the... -
Bacillus subtilis 5′-nucleotidases with various functions and substrate speci...
Abstract Background In Escherichia coli, nagD, yrfG, yjjG, yieH, yigL, surE, and yfbR encode 5′-nucleotidases that hydrolyze the phosphate group of 5′-nucleotides. In Bacillus... -
Incidence and predictors of loss to follow up among HIV-infected adults at Pa...
Abstract Objective This study was aimed at assessing the incidence of lost-to-follow-up and its predictors among HIV-positive adults after initiation into antiretroviral therapy... -
Type 2 diabetes increases oocyte mtDNA mutations which are eliminated in the ...
Abstract Background Diabetes induces many complications including reduced fertility and low oocyte quality, but whether it causes increased mtDNA mutations is unknown. Methods... -
Post renal transplant anemia: severity, causes and their association with gra...
Abstract Background Post transplantation anemia (PTA) is common among kidney transplant patients. PTA is associated with increased graft loss and in most studies with increased... -
Quorum sensing of Streptococcus mutans is activated by Aggregatibacter actino...
Abstract Background The oral cavity is inhabited by complex microbial communities forming biofilms that can cause caries and periodontitis. Cell-cell communication might play an... -
DNA-binding sequence specificity of DUX4
Abstract Background Misexpression of the double homeodomain transcription factor DUX4 results in facioscapulohumeral muscular dystrophy (FSHD). A DNA-binding consensus with two... -
Promoting deceased organ and tissue donation registration in family physician...
Abstract Background There is a worldwide shortage of organs available for transplant, leading to preventable mortality associated with end-stage organ disease. While most... -
Α de novo 3.8-Mb inversion affecting the EDA and XIST genes in a heterozygous...
Abstract Background In mammals, hypohidrotic ectodermal dysplasia (HED) is a genetic disorder that is characterized by sparse hair, tooth abnormalities, and defects in cutaneous... -
Transplantation of human dental pulp stem cells ameliorates diabetic polyneur...
Abstract Background Dental pulp stem cells (DPSCs) have high proliferation and multi-differentiation capabilities that maintain their functionality after cryopreservation. In... -
Promoter activity of Merkel cell Polyomavirus variants in human dermal fibrob...
Abstract Background Merkel cell polyomavirus (MCPyV) is a human polyomavirus that establishes a life-long harmless infection in most individuals, with dermal fibroblasts... -
Long-term outcomes of liver transplantation in patients with hepatitis C infe...
Abstract Background The use of HCV-positive livers for HCV-positive recipients is becoming more common. Our aim is to evaluate long-term outcomes in liver transplant recipients... -
Effect of cytomegalovirus reactivation on the time course of systemic host re...
Abstract Background Cytomegalovirus (CMV) reactivation in previously immunocompetent critically ill patients is associated with increased mortality, which has been hypothesized... -
Identification of a novel deletion mutation in DPY19L2 from an infertile pati...
Abstract Background Male infertility is an increasing medical concern worldwide. In most cases, genetic factors are considered as the main cause of the disease. Globozoospermia... -
Pharmacological strategies to reduce exacerbation risk in COPD: a narrative r...
Abstract Identifying patients at risk of exacerbations and managing them appropriately to reduce this risk represents an important clinical challenge. Numerous treatments have... -
Innate immune activation of astrocytes impairs neurodevelopment via upregulat...
Abstract Background Polyriboinosinic-polyribocytidylic acid (polyI:C) triggers a strong innate immune response that mimics immune activation by viral infections. Induction of...
