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Gout and sexual function: patient perspective of how gout affects personal re...
Abstract Background In absence of previous studies, we assessed how gout impacts relationship and intimacy with spouse/significant other. Methods We enrolled a convenience... -
The potassium channel KCa3.1 represents a valid pharmacological target for mi...
Abstract Background Recent studies described a critical role for microglia in Parkinson’s disease (PD), where these central nerve system resident immune cells participate in the... -
Efficacy of an aluminium triformate mouthrinse during the maintenance phase i...
Abstract Background The aim of this prospective placebo-controlled pilot study was to evaluate short-term effects of a mouthrinse containing aluminium triformate (ATF) on... -
ClC transporter activity modulates histidine catabolism in Lactobacillus reut...
Abstract Background Histamine is a key mediator of the anti-inflammatory activity conferred by the probiotic organism Lactobacillus reuteri ATCC PTA 6475 in animal models of... -
Peripheral cathepsin L inhibition induces fat loss in C. elegans and mice thr...
Abstract Background Cathepsin L and some other cathepsins have been implicated in the development of obesity in humans and mice. The functional inactivation of the proteases... -
Changes in physical activity during transition to retirement: a cohort study
Abstract Background Retirement is a major life transition which may affect lifestyle. The aim of this study is to examine within-individual changes in physical activity during... -
Relationship between age and bronchodilator response at diagnosis in adult-on...
Abstract Background Possible variation in bronchodilator response (BDR) according to age at the diagnosis of adult-onset asthma is unknown. Our aim was to assess if BDR in FEV1... -
iNOS is not responsible for RyR1 S-nitrosylation in mdx mice with truncated d...
Abstract Background Previous research indicated that nitric oxide synthase (NOS) is the key molecule for S-nitrosylation of ryanodine receptor 1 (RyR1) in DMD model mice (mdx... -
Activation of the EIF2AK4-EIF2A/eIF2α-ATF4 pathway triggers autophagy respons...
The intestinal mucosa of Crohn disease (CD) patients is abnormally colonized by adherent-invasive E. coli (AIEC). Upon AIEC infection, autophagy is induced in host cells to... -
The relationship between the effect of matured hop extract and physical activ...
Abstract Background We recently reported that successive ingestion of matured hop extract (MHE), produced by oxidation of hops, results in a reduction of body fat in healthy... -
Transcriptomic data from two primary cell models stimulating human monocytes ...
Abstract Background Biological interpretation of DNA microarray data may differ depending on underlying assumptions and statistical tests of bioinformatics tools used. We used... -
ConFIRM trial - conversion of in vitro fertilization cycles to intrauterine i...
Abstract Background To date, there is no consensus on the ideal management strategy of patients with poor ovarian response (POR) to controlled ovarian stimulation (COS) for in... -
Transient receptor potential ankyrin 1 (TRPA1) is functionally expressed in p...
Abstract Background Transient receptor potential ankyrin 1 (TRPA1) is a membrane-associated cation channel, widely expressed in neuronal cells and involved in nociception and... -
Association of informal caregiving with body mass index and frequency of spor...
Abstract Background While most studies focused solely on the comparison between informal caregivers and non-caregivers, little is known about the relation between caregiving... -
Use of a decision aid did not decrease decisional conflict in patients with c...
Abstract Background Although a model for shared decision-making is important for patient-centered care, decisional conflict can emerge when patients participate in the... -
Copenhagen comorbidity in HIV infection (COCOMO) study: a study protocol for ...
Abstract Background Modern combination antiretroviral therapy (cART) has improved survival for people living with HIV (PLWHIV). Non-AIDS comorbidities have replaced... -
Do some anxiety disorders belong to the prodrome of bipolar disorder? A clini...
Abstract Background In clinical practice, some patients diagnosed with anxiety disorder (AD) may develop bipolar disorder (BD) many years later, and some cases of AD may be... -
Orexin A alleviates neuroinflammation via OXR2/CaMKKβ/AMPK signaling pathway ...
Abstract Background Orexins are two neuropeptides (orexin A, OXA; orexin B, OXB) secreted mainly from the lateral hypothalamus, which exert a wide range of physiological effects... -
Measuring inconsistency in research ethics committee review
Abstract Background The review of human participant research by Research Ethics Committees (RECs) or Institutional Review Boards (IRBs) is a complex multi-faceted process that... -
Increased mortality in elderly patients with acute respiratory distress syndr...
Abstract Background Advanced age is associated with increased mortality in acute respiratory distress syndrome (ARDS) patients. Preclinical studies suggest that the host...
