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Altered functional connectivity of the nucleus accumbens subdivisions in amph...
Abstract Background The growing abuse of amphetamine-type stimulants leads to new challenges to human health. A possible addiction mechanism has been proposed by altered... -
Hospital utilization rates following antipsychotic dose reductions: implicati...
Abstract Background Data are limited on the benefits and risks of dose reduction in managing side effects associated with antipsychotic treatment. As an example, antipsychotic... -
An interprofessional cohort analysis of student interest in medical ethics ed...
Abstract Background There is continued need for enhanced medical ethics education across the United States. In an effort to guide medical ethics education reform, we report the... -
Optimizing adalimumab treatment in psoriasis with concomitant methotrexate (O...
Abstract Background The introduction of anti-tumor necrosis factor medications has revolutionized the treatment of psoriasis with achievement of treatment goals (Psoriasis Area... -
Vasoresponsiveness in patients with heart failure (VASOR): protocol for a pro...
Abstract Background Vasoplegia is a severe complication which may occur after cardiac surgery, particularly in patients with heart failure. It is a result of activation of... -
The whole - genome expression analysis of peripheral blood mononuclear cells ...
Abstract Background Up to 30 % of adults with severe asthma are hypersensitive to aspirin and no unambiguous theory exists which provides a satisfactory explanation for the... -
Cutaneous neurofibromas: patients’ medical burden, current management and the...
Abstract Background Neurofibromatosis type 1 is an inherited condition with variable phenotypic expression and a high medical and social burden. The objectives of this patient... -
Feasibility study to identify women of childbearing age at risk of pregnancy ...
Abstract Background Worldwide the rate of unplanned pregnancies is more than 40%. Identifying women at risk of pregnancy can help prevent negative outcomes and also reduce... -
Inequalities, harm reduction and non-combustible nicotine products: a meta-et...
Abstract Background We sought to review qualitative evidence on how smokers in different socioeconomic groups engage with non-combustible nicotine products (NCNP), including... -
Evaluation in alcohol use disorders – insights from the nalmefene experience
Abstract Nalmefene was the first treatment approved by the European Medicines Agency for reducing alcohol consumption in adult patients with alcohol dependence. It is often... -
Cost-effectiveness of nivolumab plus ipilimumab as first-line therapy in adva...
Abstract Background Nivolumab plus ipilimumab improves overall survival and is associated with less toxicity compared with sunitinib in the first-line setting of advanced... -
Differential expression of E-type prostanoid receptors 2 and 4 in microglia s...
Abstract Background Cyclooxygenase-2 (COX-2) is induced under inflammatory conditions, and prostaglandin E2 (PGE2) is one of the products of COX activity. PGE2 has pleiotropic... -
Controlling schistosomiasis with praziquantel: How much longer without a viab...
Abstract The current approach of morbidity control of schistosomiasis, a helminth disease of poverty with considerable public health and socioeconomic impact, is based on... -
Periostin involved in the activated hepatic stellate cells-induced progressio...
Abstract Background Incomplete thermal ablation may induce invasiveness of hepatocellular carcinoma (HCC). Here, we investigated whether activated hepatic stellate cells (HSCs)... -
Aerosolized antibiotics for ventilator-associated pneumonia: a pairwise and B...
Abstract Background Aerosolized antibiotics have been proposed as a novel and promising treatment option for the treatment of ventilator-associated pneumonia (VAP). However, the... -
‘You don’t throw these things out:’ an exploration of medicines retention and...
Abstract Background Consumers most commonly discard unwanted medicines in household rubbish or drains, however, there are global concerns over the extent, environmental impact... -
Degree of dyspnoea at admission and discharge in patients with heart failure ...
Abstract Background Dyspnoea is a disabling symptom in patients admitted with heart failure (HF) and respiratory diseases (RD). The main aim of this study is to evaluate its... -
Long-term Safety and Efficacy of Human-Induced Pluripotent Stem Cell (iPS) Gr...
Abstract The U.S. Food and Drug Administration recently approved phase I/II clinical trials for embryonic stem (ES) cell-based retinal pigmented epithelium (RPE)... -
Risk factors influencing survival of acellular porcine corneal stroma in infe...
Abstract Background A worldwide lack of donor corneas demands the bioengineered corneas be developed as an alternative. The primary objective of the current study was to... -
Availability, accessibility and delivery to patients of the 28 orphan medicin...
Abstract Background The European Medicine Agency granted marketing approval to 164 orphan medicinal products for rare diseases, among which 28 products intended for the...
