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MicroRNA-223 demonstrated experimentally in exosome-like vesicles is associat...
Abstract Background Previous findings have demonstrated that lumbar radicular pain after disc herniation may be associated with up-regulation of inflammatory mediators. In the... -
Epidermal growth factor prevents APOE4 and amyloid-beta-induced cognitive and...
Abstract Cerebrovascular (CV) dysfunction is emerging as a critical component of Alzheimer’s disease (AD), including altered CV coverage. Angiogenic growth factors (AGFs) are... -
Attention deficit hyperactivity disorder: genetic association study in a coho...
Abstract Background Attention deficit hyperactivity disorder (ADHD) has a strong genetic component. The study is aimed to test the association of 34 polymorphisms with ADHD... -
17-β estradiol increases parvalbumin levels in Pvalb heterozygous mice and at...
Abstract Background Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by two core symptoms: impaired social interaction and communication,... -
Emergency transapical mitral valve-in-valve implantation for bioprosthesis fa...
Abstract Background Valve-in-Valve (VIV) Transcatheter Aortic Valve Replacement (TAVR) is now the treatment of choice in high-surgical-risk patients with failing aortic... -
Pellino1 regulates neuropathic pain as well as microglial activation through ...
Abstract Background Spinal cord microglia plays a crucial role in the pathogenesis of neuropathic pain. However, the mechanisms underlying spinal microglial activation during... -
Oxysterol levels and metabolism in the course of neuroinflammation: insights ...
Abstract Background Oxysterols are cholesterol derivatives that have been suggested to play a role in inflammatory diseases such as obesity, atherosclerosis, or... -
miRNA-23a/CXCR4 regulates neuropathic pain via directly targeting TXNIP/NLRP3...
Abstract Background Chemokine CXC receptor 4 (CXCR4) in spinal glial cells has been implicated in neuropathic pain. However, the regulatory cascades of CXCR4 in neuropathic pain... -
Suppression of CHRN endocytosis by carbonic anhydrase CAR3 in the pathogenesi...
Myasthenia gravis is an autoimmune disorder of the neuromuscular junction manifested as fatigable muscle weakness, which is typically caused by pathogenic autoantibodies against... -
A mitochondrial division inhibitor, Mdivi-1, inhibits mitochondrial fragmenta...
Abstract Background Kainic acid (KA)-induced excitotoxicity promotes cytoplasmic calcium accumulation, oxidative stress, and apoptotic signaling, leading to hippocampal neuronal... -
TRPV1 mediates astrocyte activation and interleukin-1β release induced by hyp...
Abstract Background Hypoxic-ischemic encephalopathy (HIE) is a serious birth complication with high incidence in both advanced and developing countries. Children surviving from... -
Low back pain and limitations of daily living in Asia: longitudinal findings ...
Abstract Background Low back pain (LBP) is a major cause of disability throughout the world. However, longitudinal evidence to relate low back pain and functional limitations is... -
Risk of atrial fibrillation in persons with type 2 diabetes and the excess ri...
Abstract Background To examine the incidence of atrial fibrillation in individuals with type 2 diabetes compared with age- and sex-matched controls from the general population... -
Human Herpesvirus-6 corneal Endotheliitis after intravitreal injection of Ran...
Abstract Background To report the first case of human herpesvirus-6 (HHV-6) corneal endotheliitis that developed after intravitreal ranibizumab injections. Case presentation A... -
Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3...
Abstract Background Misfolding and aggregation of the presynaptic protein alpha-synuclein (αsyn) is a hallmark of Parkinson’s disease (PD) and related synucleinopathies.... -
BDNF reverses aging-related microglial activation
Abstract Background Excessive microglial activation is implicated in the pathogenesis of various age-related neurodegenerative diseases. In addition to neurons, brain-derived... -
Exhaustion of mitochondrial and autophagic reserve may contribute to the deve...
Abstract Background Mutations in leucine rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). Mitochondrial and autophagic dysfunction... -
Higher fatty liver index is associated with increased risk of new onset heart...
Abstract Background Heart failure (HF) is relatively common cardiovascular disease with high mortality and morbidity. Although it is associated with many cardiovascular risk... -
Identifying individuals with chronic pain after knee replacement: a populatio...
Abstract Background Approximately one in five patients undergoing knee replacement surgery experience chronic pain after their operation, which can negatively impact on their... -
Global Hypoxia-Ischemia Induced Inflammation and Structural Changes in the Pr...
Abstract Perinatal asphyxia, a condition of impaired gas exchange during birth, leads to fetal hypoxia-ischemia (HI) and is associated with postnatal adverse outcomes including...
