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Prescription of antibiotics to children with acute otitis media in Danish gen...
Abstract Background Acute otitis media (AOM) is a common and most often self-limiting infection in childhood, usually managed in general practice. Even though antibiotics are... -
The USP18 cysteine protease promotes HBV production independent of its protea...
Abstract Background Hepatitis B virus (HBV) infection remains as one of the major public health problems in the world. Type I interferon (IFN) plays an essential role in... -
Delineation of the population genetic structure of Culicoides imicola in East...
Abstract Background Culicoides imicola Kieffer, 1913 is the main vector of bluetongue virus (BTV) and African horse sickness virus (AHSV) in Sub-Saharan Africa. Understanding... -
Invasive DNA elements modify the nuclear architecture of their insertion site...
Abstract Background The three-dimensional (3D) organization of chromosomes is linked to epigenetic regulation and transcriptional activity. However, only few functional features... -
Temporal transcriptional patterns of cyanophage genes suggest synchronized in...
Abstract Background Based on the peak expression times during infection, early, middle, and late genes have been characterized in viruses (cyanophages) that infect the... -
The GBA p.G85E mutation in Korean patients with non-neuronopathic Gaucher dis...
Abstract Background Gaucher disease (GD) is caused by a deficiency of β-glucocerebrosidase, encoded by GBA. Haplotype analyses previously demonstrated founder effects for... -
The genomic study of an environmental isolate of Scedosporium apiospermum sho...
Abstract Crude oil contamination of soils and waters is a worldwide problem, which has been actively addressed in recent years. Sequencing genomes of microorganisms involved in... -
Using smartphones to decrease substance use via self-monitoring and recovery ...
Abstract Background Alcohol abuse, other substance use disorders, and risk behaviors associated with the human immunodeficiency virus (HIV) represent three of the top 10... -
The intermediary as an institutional entrepreneur: institutional change and s...
Abstract This paper aims to illustrate how the triple-helix concept can be implemented on a city level by establishing an intermediary among the scientific, economic, and public... -
Mutational signatures: experimental design and analytical framework
Abstract Mutational signatures provide a powerful alternative for understanding the pathophysiology of cancer. Currently, experimental efforts aimed at validating and... -
Noninvasive ventilation for severely acidotic patients in respiratory interme...
Abstract Background Severe acidosis can cause noninvasive ventilation (NIV) failure in chronic obstructive pulmonary disease (COPD) patients with acute hypercapnic respiratory... -
Self-efficacy and self-management strategies in acute intermittent porphyria
Abstract Background Acute intermittent porphyria (AIP) is an inherited metabolic disease with low clinical penetrance caused by mutations in the hydroxymethylbilane (HMBS) gene.... -
A self-marker-like protein governs hemocyte allorecognition in Halocynthia ro...
Abstract Background Self-incompatibility, fusion/non-fusion reactions, and contact reactions (CRs) have all been identified as allorecognition phenomena in ascidians. CR is a... -
Molecular detection and phylogenetic analysis of lumpy skin disease virus fro...
Abstract Background Lumpy skin disease (LSD) is an infectious viral disease of cattle caused by a Capripoxvirus. LSD has substantial economic implications, with infection... -
Transcriptomic analysis of monocytes from HIV-positive men on antiretroviral ...
Abstract Background Tobacco smoking induces immunomodulatory and pro-inflammatory effects associated with transcriptome changes in monocytes and other immune cell types. While... -
A novel Sugarcane bacilliform virus promoter confers gene expression preferen...
Abstract Background Saccharum species such as sugarcane and energy cane are key players in the expanding bioeconomy for sugars, bioenergy, and production of high-value proteins.... -
Metagenomic analysis of viral nucleic acid extraction methods in respiratory ...
Abstract Background Numerous protocols for viral enrichment and genome amplification have been created. However, the direct identification of viral genomes from clinical... -
Overcoming species barriers: an outbreak of Lagovirus europaeus GI.2/RHDV2 in...
Abstract Background Prior to 2010, the lagoviruses that cause rabbit hemorrhagic disease (RHD) in European rabbits (Oryctolagus cuniculus) and European brown hare syndrome... -
Archaic mitochondrial DNA inserts in modern day nuclear genomes
Abstract Background Traces of interbreeding of Neanderthals and Denisovans with modern humans in the form of archaic DNA have been detected in the genomes of present-day human...
