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Epigenetic and transcriptional regulation of autophagy
Macroautophagy (hereafter referred to as autophagy) is an essential self-digestion process to maintain homeostasis and promote survival in response to starvation. Although the... -
r37980778c78--cac954693b977f3a63000b1da32e5eb0
Identified TFs and the corresponding protein fragments. -
r37980778c78--f1b8fef03034c81d7c00289139a24aea
Cell lysates from Ls174T CRCs were immunoprecipitated with antibodies against endogenous MLLT10/AF10 (A) and DOT1L (B) complexes and analyzed by Western blotting with the... -
The Paf1 complex transcriptionally regulates the mitochondrial-anchored prote...
Mitophagy is a critical process that safeguards mitochondrial quality control in order to maintain proper cellular homeostasis. Although the mitochondrial-anchored receptor... -
Murine Gamma-Herpesvirus 68 Hijacks MAVS and IKKβ to Initiate Lytic Replication
Upon viral infection, the mitochondrial antiviral signaling (MAVS)-IKKβ pathway is activated to restrict viral replication. Manipulation of immune signaling events by pathogens... -
Plasmids used in this study.
aLike YCpHA-BUD8 [20] except in a YEplac111 [53] background.bLike YEpGFP*-BUD8 [20] except with two in-frame copies of the GFP coding sequence and in a YCplac33 [53] background. -
Transcription of highly repetitive tandemly organized DNA in amphibians and b...
Tandemly organized highly repetitive DNA sequences are crucial structural and functional elements of eukaryotic genomes. Despite extensive evidence, satellite DNA remains an... -
r37980778c78--f940d903f1b3141f262bffaa81707dae
(A–F) In situ hybridization for tcf7l2 (A), mllt10/af10 (C), and dot1l (E) in whole embryos at 80 hpf. In situ hybridization for tcf7l2 (B), mllt10/af10 (D), and dot1l (F) in... -
The First Locked Side-Chain Analogues of Calcitriol (1α,25-Dihydroxyvitamin D...
We describe the synthesis of the first locked side-chain analogues of the natural hormone 1α,25-(OH)2-D3 and their effects on gene transcription in human colon cancer cells.... -
r37980778c78--b34210801093a211eb0831b17bea1de9
The importance of DNA supercoiling in transcriptional regulation has been known for many years, and more recently, transcription itself has been shown to be a source of this... -
r37980778c78--9d13dd1cca619420f0c068de3fb5de93
Superhelically curved DNA structures can strongly activate transcription in mammalian cells. However, the mechanism underlying the activation has not been clarified. We... -
PITX1, a specificity determinant in the HIF-1α-mediated transcriptional respo...
Hypoxia is an important developmental cue for multicellular organisms but it is also a contributing factor for several human pathologies, such as stroke, cardiovascular diseases... -
Primer pairs used for ChIP and FAIRE analysis of HPV18 genomes.
Primer pairs used for ChIP and FAIRE analysis of HPV18 genomes. -
r37980778c78--c092c723bae7dd341c1510958290d83c
(A) IKKβ or IKKβΔKD purified from 293T cells (left) were incubated with [32P]γATP and bacterial GST fusion proteins containing RTA fragments (middle), and examined by... -
Disruption of CTCF-YY1–dependent looping of the human papillomavirus genome a...
The complex life cycle of oncogenic human papillomavirus (HPV) initiates in undifferentiated basal epithelial keratinocytes where expression of the E6 and E7 oncogenes is... -
Mllt10/Af10 co-immunoprecipitates with Tcf4 in the mouse small intestinal crypt.
(A) Cell lysates from purified crypt fractions were immunoprecipitated with antibodies directed against endogenous Tcf4, β-catenin, and (B) Mllt10/Af10 as indicated and analyzed... -
r37980778c78--cc1e34e43535230dac9e69c516be49c6
Cellular sensitivity to UV-irradiation is mediated by RNA polymerase I transcription Sheet 0 -
Rates of spontaneous GCRs
Rates of spontaneous GCRs were determined using biologically independent cultures. A set of GCR rates that appear in one figure in the paper are shown in one sheet.
