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Serum progesterone distribution in normal pregnancies compared to pregnancies...
Abstract Background Progesterone is a critical hormone in early pregnancy. A low level of serum progesterone is associated with threatened miscarriage. We aim to establish the... -
A Bayesian network meta-analysis on the efficacy and safety of eighteen targe...
Pulmonary arterial hypertension (PAH) can be relieved by pharmacological interventions, especially the targeted drug, which is classified into endothelin receptor antagonist,... -
Comparison of anti-malarial drugs efficacy in the treatment of uncomplicated ...
Abstract Background Artemisinin-based combination therapy (ACT) and novel drug combinations are available and used in African countries to treat uncomplicated malaria. Network... -
A systematic review of clinical audit in companion animal veterinary medicine
Abstract Background Clinical audit is a quality improvement process with the goal of continuously improving quality of patient care as assessed by explicit criteria. In human... -
Comparative analyses of the in vivo induction and transmission of α-synuclein...
Abstract α-synuclein (αS) is the major component of several types of brain pathological inclusions that define neurodegenerative diseases termed synucleinopathies. Central... -
HIV-1 integrase resistance associated mutations and the use of dolutegravir i...
Abstract Background Sub-Saharan Africa carries the greatest burden of HIV-infection with increasing drug resistance burden, which requires improved patient management and... -
Differences in lipid metabolism between anagliptin and sitagliptin in patient...
Abstract Background Anagliptin, a dipeptidyl peptidase-4 inhibitor, is reported to reduce the level of low-density lipoprotein cholesterol (LDL-C). The underlying mechanism of... -
An interview study of pregnant women who were provided with indoor air qualit...
Abstract Background Maternal smoking can cause health complications in pregnancy. Particulate matter (PM2.5) metrics applied to second hand smoke (SHS) concentrations provide... -
Genes targeted by the Hedgehog-signaling pathway can be regulated by Estrogen...
Abstract Background Nuclear receptor family member, Estrogen related receptor β, and the Hedgehog signal transduction pathway are both reported to relate to tumorigenesis and... -
Perioperative statin therapy in cardiac and non-cardiac surgery: a systematic...
Abstract Background The effects of perioperative statin therapy on clinical outcome after cardiac or non-cardiac surgery are controversial. We aimed to assess the association... -
Safety, pharmacokinetics, and antitumor properties of anlotinib, an oral mult...
Abstract Background Anlotinib is a novel multi-target tyrosine kinase inhibitor that is designed to primarily inhibit VEGFR2/3, FGFR1-4, PDGFR α/β, c-Kit, and Ret. We aimed to... -
The magnitude of antibiotic resistance to Helicobacter pylori in Africa and i...
Abstract Background Worldwide Helicobacter pylori (H.pylori) treatment is of great challenge due to increased antibiotic resistance. The burden of H. pylori antibiotic... -
Effect of exercise type on smoking cessation: a meta-analysis of randomized c...
Abstract Background Exercise is one choice of additional treatment for smoking cessation by relieving nicotine withdrawal symptoms and smoking craving. The possible mechanism of... -
Estimating the cost-effectiveness of daclatasvir + sofosbuvir versus sofosbuv...
Abstract Background As treatments for chronic hepatitis C are moving away from interferon-containing regimens, the most appropriate allocation of resources to higher cost,... -
Statin drugs to reduce breast cancer recurrence and mortality
Abstract Epidemiologic studies have, variably, shown the concomitant use of statin drugs to be beneficial to cancer outcomes. Statin drugs have been FDA approved for three... -
808 nm-activable core@multishell upconverting nanoparticles with enhanced sta...
Abstract Background The unique upconversion properties of rare-earth-doped nanoparticles offers exciting opportunities for biomedical applications, in which near-IR remote... -
Treating tobacco dependence in older adults: a survey of primary care clinici...
Abstract Background The benefits of smoking cessation among older people are well documented. Despite this, evidence suggests that older smokers are rarely engaged in smoking... -
Development of a core outcome set for clinical trials in facial aging: study ...
Abstract Background Facial aging is a concern for many patients. Wrinkles, loss of volume, and discoloration are common physical manifestations of aging skin. Genetic heritage,... -
Improved homology modeling of the human & rat EP4 prostanoid receptors
Abstract Background The EP4 prostanoid receptor is one of four GPCRs that mediate the diverse actions of prostaglandin E2 (PGE2). Novel selective EP4 receptor agonists would... -
Systemic bevacizumab for high-output cardiac failure in hereditary hemorrhagi...
Abstract Background Systemic bevacizumab is a novel targeted anti-angiogenic therapy for high-output cardiac failure (HOCF) in hereditary hemorrhagic telangiectasia (HHT) but...
