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Systematic review of outcome domains and instruments used in clinical trials ...
Abstract Background There is no evidence-based guidance to facilitate design decisions for confirmatory trials or systematic reviews investigating treatment efficacy for adults... -
M1-like tumor-associated macrophages activated by exosome-transferred THBS1 p...
Abstract Background Treatment strategies targeting tumor-associated macrophages (TAMs) have been proposed in cancer areas. The functional alterations of macrophages in the... -
Effect of smoking status on lung function, patient-reported outcomes, and saf...
Abstract Background Smoking is a major risk factor for COPD and may impact the efficacy of COPD treatments; however, a large proportion of COPD patients continue to smoke... -
Central nervous system progression in advanced non–small cell lung cancer pat...
Abstract Background Central nervous system (CNS) brain metastasis of advanced non-small cell lung cancer (NSCLC) patients confers a worse quality of life and prognosis. The... -
Amorphous silica nanoparticles induce malignant transformation and tumorigene...
Rapid development and deployment of engineered nanomaterials, such as amorphous silica nanoparticles (SiNPs) in various commercial and biomedical applications have raised... -
High cholesterol induces apoptosis and autophagy through the ROS-activated AK...
Abstract Background Hypercholesterolemia increases the risk of tendon pain and tendon rupture. Tendon-derived stem cells (TDSCs) play a vital role in the development of... -
LncRNA RP11-436H11.5, functioning as a competitive endogenous RNA, upregulate...
Abstract Background Accumulating evidence indicates that long non-coding RNAs (lncRNAs) play a crucial role in tumorigenesis. Here, we report a novel lncRNA, RP11-436H11.5, that... -
Current practice in analysing and reporting binary outcome data—a review of r...
Abstract Background Randomised controlled trials (RCTs) need to be reported so that their results can be unambiguously and robustly interpreted. Binary outcomes yield unique... -
Minimally invasive dual incision with mini plate internal fixation improves o...
Abstract Background Calcaneal Sanders type III or higher fractures traditionally have been treated with open reduction and internal fixation (ORIF); however, ORIF has associated... -
ConFIRM trial - conversion of in vitro fertilization cycles to intrauterine i...
Abstract Background To date, there is no consensus on the ideal management strategy of patients with poor ovarian response (POR) to controlled ovarian stimulation (COS) for in... -
Transient receptor potential ankyrin 1 (TRPA1) is functionally expressed in p...
Abstract Background Transient receptor potential ankyrin 1 (TRPA1) is a membrane-associated cation channel, widely expressed in neuronal cells and involved in nociception and... -
Effect of hCMSCs and liraglutide combination in ALI through cAMP/PKAc/β-caten...
Abstract Background ALI/ARDS is the major cause of acute respiratory failure in critically ill patients. As human chorionic villi-derived MSCs (hCMSCs) could attenuate ALI in... -
Statin use in cancer survivors versus the general population: cohort study us...
Abstract Background Cancer survivors may be at increased risk of cardiovascular diseases, but little is known about whether prescribing guidelines for the primary prevention of... -
Postmarketing commitments for novel drugs and biologics approved by the US Fo...
Abstract Background Postmarketing commitments are clinical studies that pharmaceutical companies agree to conduct at the time of FDA approval, but which are not required by... -
ERα-36 regulates progesterone receptor activity in breast cancer
Abstract Background Alterations in estrogen and progesterone signaling, via their respective receptors, estrogen receptor alpha (ERα) and progesterone receptor (PR),... -
Optical coherence tomography features of retinal lesions in Chinese patients ...
Abstract Background To evaluate the optical coherence tomography (OCT) features of retinal lesions in Chinese patients with endogenous Candida endophthalmitis (ECE). Methods We... -
Impact of pharmacy-led medication reconciliation on admission to internal med...
Abstract Background The Institute for Healthcare Improvement identifies medication reconciliation as the shared responsibility of nurses, pharmacists, and physicians, where each... -
Postpartum women’s use of medicines and breastfeeding practices: a systematic...
Abstract The objectives of this article are to systematically review i) the extent of medicine use in postpartum women, and ii) the impact of maternal medicine use (excluding... -
Prevention of multiple system atrophy using human bone marrow-derived mesench...
Abstract Background Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder of unknown etiology, but is closely associated with damage to dopaminergic neurons.... -
Systematic literature review and meta-analysis of the efficacy of artemisinin...
Abstract Background There is no agreed standard method to assess the efficacy of anti-malarials for uncomplicated falciparum in pregnancy despite an increased risk of adverse...
