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CellTag Indexing: genetic barcode-based sample multiplexing for single-cell g...
Abstract High-throughput single-cell assays increasingly require special consideration in experimental design, sample multiplexing, batch effect removal, and data... -
Comparing structural fingerprints using a literature-based similarity benchmark
Abstract Background The concept of molecular similarity is one of the central ideas in cheminformatics, despite the fact that it is ill-defined and rather difficult to assess... -
Risk analysis for confined space entries: critical analysis of four tools app...
Investigation reports of fatal confined space accidents nearly always point to a problem of identifying or underestimating risks. This paper compares 4 different risk analysis... -
MOdified DIagnostic strateGy to safely ruLe-out pulmonary embolism In the eme...
Abstract Introduction In the work-up strategy for pulmonary embolism (PE) in the ED, the recently introduced YEARS rule allows the raising of the D-dimer threshold to 1000 ng/ml... -
Unveiling patterns of international communities in a global city using mobile...
Abstract We analyse a large mobile phone activity dataset provided by Telecom Italia for the Telecom Big Data Challenge contest. The dataset reports the international country... -
Efficacy of a training programme to support the application of the guideline ...
Abstract Background The evidence-based guideline entitled guideline evidence-based health information emerged from the German Network for Evidence-based Medicine (DNEbM) and was... -
A data infrastructure for the assessment of health care performance: lessons ...
Abstract The integration of different administrative data sources from a number of European countries has been shown useful in the assessment of unwarranted variations in health... -
Improving enhanced recovery after surgery (ERAS): ERAS APPtimize study protoc...
Abstract Background Perioperative care in colorectal surgery is systematically defined in the Enhanced Recovery After Surgery (ERAS) protocol. The ERAS protocol improves... -
Controlling schistosomiasis with praziquantel: How much longer without a viab...
Abstract The current approach of morbidity control of schistosomiasis, a helminth disease of poverty with considerable public health and socioeconomic impact, is based on... -
A measure of the impact of CV incompleteness on prediction error estimation w...
Abstract Background In applications of supervised statistical learning in the biomedical field it is necessary to assess the prediction error of the respective prediction rules.... -
Pseudonymization for research data collection: is the juice worth the squeeze?
Abstract Background The collection of data and biospecimens which characterize patients and probands in-depth is a core element of modern biomedical research. Relevant data must... -
Contributions of information and communications technology to future health s...
Abstract Background Demographic changes in the pattern of disease burden, escalating health expenditures and inequitable access to healthcare are global challenges. Irrespective... -
Changing the Antibiotic Prescribing of general practice registrars: the ChAP ...
Abstract Background Australian General Practitioners (GPs) are generous prescribers of antibiotics, prompting concerns including increasing antimicrobial resistance in the... -
Estimating the nationwide transmission risk of measles in US schools and impa...
Abstract Background The spread of airborne infectious diseases such as measles is a critical public health concern. The U.S. was certified measles-free in 2000, but the number... -
How do we define the policy impact of public health research? A systematic re...
Abstract Background In order to understand and measure the policy impact of research we need a definition of research impact that is suited to the task. This article... -
Buying and selling human eggs: infertility providers’ ethical and other conce...
Abstract Background Egg donor agencies are increasingly being used as part of IVF in the US, but are essentially unregulated, posing critical ethical and policy questions... -
GCAC: galaxy workflow system for predictive model building for virtual screening
Abstract Background Traditional drug discovery approaches are time-consuming, tedious and expensive. Identifying a potential drug-like molecule using high throughput screening... -
ATLANTIS: a randomised multi-arm phase II biomarker-directed umbrella screeni...
Abstract Background Metastatic urothelial cancer (UC) is the eighth most common cause of cancer death in the UK. Standard first-line treatment, for most patients, is cytotoxic... -
Mapping evidence on malnutrition screening tools for children under 5 years i...
Abstract Background In sub-Saharan Africa (SSA), malnutrition remains a major public health challenge, particularly among children under 5 years of age. Despite nutritional... -
Improving cooperation between general practitioners and dermatologists via te...
Abstract Background Internationally, teledermatology has proven to be a viable alternative to conventional physical referrals. Travel cost and referral times are reduced while...
