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Transcriptomic analysis of monocytes from HIV-positive men on antiretroviral ...
Abstract Background Tobacco smoking induces immunomodulatory and pro-inflammatory effects associated with transcriptome changes in monocytes and other immune cell types. While... -
A novel Sugarcane bacilliform virus promoter confers gene expression preferen...
Abstract Background Saccharum species such as sugarcane and energy cane are key players in the expanding bioeconomy for sugars, bioenergy, and production of high-value proteins.... -
Metagenomic analysis of viral nucleic acid extraction methods in respiratory ...
Abstract Background Numerous protocols for viral enrichment and genome amplification have been created. However, the direct identification of viral genomes from clinical... -
Overcoming species barriers: an outbreak of Lagovirus europaeus GI.2/RHDV2 in...
Abstract Background Prior to 2010, the lagoviruses that cause rabbit hemorrhagic disease (RHD) in European rabbits (Oryctolagus cuniculus) and European brown hare syndrome... -
Trends in anemia care in non-dialysis-dependent chronic kidney disease (CKD) ...
Abstract Background The objective of the study was to examine overall anemia management trends in non-dialysis patients with chronic kidney disease (CKD) from 2006 to 2015, and... -
Microglial depletion and repopulation in brain slice culture normalizes sensi...
Abstract Background Microglia are critical mediators of neuroimmune pathology across multiple neurologic disorders. Microglia can be persistently activated or “primed” by... -
Archaic mitochondrial DNA inserts in modern day nuclear genomes
Abstract Background Traces of interbreeding of Neanderthals and Denisovans with modern humans in the form of archaic DNA have been detected in the genomes of present-day human... -
Impact of type 2 diabetes mellitus on mid-term mortality for hypertrophic car...
Abstract Background Type 2 diabetes mellitus is common in cardiovascular disease. It is associated with adverse clinical outcomes for patients who had undergone coronary artery... -
An open-label, long-term, phase III extension trial of duloxetine in Japanese...
Objectives: We aimed to evaluate the long-term safety and efficacy of duloxetine 60 mg in Japanese patients with fibromyalgia enrolled from a preceding randomized,... -
SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ...
Abstract Background Data on SARS-CoV-2 load in lower respiratory tract (LRT) are scarce. Our objectives were to describe the viral shedding and the viral load in LRT and to... -
The impact of diabetes on multiple avoidable admissions: a cross-sectional study
Abstract Background Multiple admissions for ambulatory care sensitive conditions (ACSC) are responsible for an important proportion of health care expenditures. Diabetes is one... -
Quantitative benefit-risk assessment of methylprednisolone in multiple sclero...
Abstract Background High-dose short-term methylprednisolone is the recommended treatment in the management of multiple sclerosis relapses, although it has been suggested that...
