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Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,...
Efforts to identify a suitable follow-on compound to razaxaban (compound 4) focused on modification of the carboxamido linker to eliminate potential in vivo hydrolysis to a... -
The imprint of X-ray photoevaporation on the orbital distribution of giant pl...
Recent exoplanet surveys have highlighted the existence of an impressive diversity of planetary systems, raising the question of how systems similar to our own can form and... -
dedup_wf_001--4edd6b37544e4fc6acb3bb4fce0088b7
A major bottleneck for the exploitation of data from the Kepler mission for stellar astrophysics and exoplanet research has been the lack of precise radii and evolutionary... -
r37980778c78--56fcee8741a21a8729fa2db393bd30b0
Design, synthesis, and in vitro bioevaluation of a new class of potential dual PPARα and γ agonists discovered through a structure-driven design paradigm are described. The... -
Effect of a 17α-(3-Hydroxypropyl)-17β-acetyl Substituent Pattern on the Gluco...
Replacing the 17α-acetoxy substituent in an antiprogestational 17β-acetyl-11β-arylestra-4,9-dien-3-one by 3-hydroxypropyl significantly diminished glucocorticoid receptor... -
r37980778c78--45c77806280e278526960e808d2b7b2b
Electrolysis of benzylthiocyanate, benzyl chloride, p-methylbenzyl chloride, p-methoxybenzyl chloride, or toluene in acetonitrile, at platinum electrodes in a two compartments... -
Additional file 1 of Single-dose fosaprepitant for the prevention of chemothe...
Additional file 1. List of Independent Ethics Committees (IECs). -
(Non-)Ellipses in Dutch, English, and German: The case of because X
In this paper, we offer an analysis of the because X construction as non-elliptical structures. Beside English, Dutch, and German, similar constructions exist in a number of... -
Damage potential of Drosophila suzukii and development of phytosanitary measu...
Slide of the Euphresco project 'Damage potential of Drosophila suzukii and development of phytosanitary measures' (DROSKII) Project funded through the Euphresco network -
Controlling the Carbon Nanotube-to-Medium Conductivity Ratio for Dielectropho...
The surface conductivity of colloidal nanotubes, induced by ionic surfactants, is known to affect alternating current dielectrophoresis, which has been actively investigated... -
r37980778c78--e170182138de6ef7bc3c4cb7648e0d3b
New polypyridine-macrocyclic receptors for glucopyranosides were designed and synthesized. The artificial receptors possess a terpyridine skeleton as a hydrogen-bonding site and... -
Enantioselective Epoxidation of Terminal Olefins by Chiral Dioxirane
This paper describes an enantioselective epoxidation of terminal olefins using chiral ketone 3 as catalyst and Oxone as oxidant. Up to 85% ee has been obtained. -
Novel γ-Aminobutyric Acid ρ<sub>1</sub> Receptor Antagonists; Synthesis, Phar...
γ-Aminobutyric acid (GABA) analogues based on 4-amino-cyclopent-1-enyl phosphinic acid (34−42) and 3-aminocyclobutane phosphinic acids (51, 52, 56, 57) were investigated in... -
Additional file 1 of TNFAIP8 promotes AML chemoresistance by activating ERK s...
Additional file 1: Table S1. Transcription factors that bound around TNFAIP8 gene. -
Rationale, Design, and Synthesis of Novel Phenyl Imidazoles as Opioid Recepto...
A small series of novel, imidazoles 4 have been prepared that exhibit very good binding affinities for the δ and μ opioid receptors (ORs), as well as demonstrate potent agonist... -
Pharmacomodulations around the 4-Oxo-1,4-dihydroquinoline-3-carboxamides, a C...
CB2 receptor selective ligands are becoming increasingly attractive drugs due to the potential role of this receptor in several physiopathological processes. Thus, the... -
Biohacking in Africa: A Tool for Justice, Empowerment, and Development
SOHA project evidences on: obstacles to the adoption of Open Science in Haiti and Africa Panel on Inclusion and Diversity MIT-MediaLab 22 – 24 september 2017 -
Renormalization-Group Equations Of Neutrino Masses And Flavor Mixing Paramete...
We apply the general idea of renormalization-group equations (RGEs) to understand how neutrino masses and flavor mixing parameters evolve when neutrinos propagate in a medium.... -
Synthesis of Classical, Four-Carbon Bridged 5-Substituted Furo[2,3-<i>d</i>]p...
We report, for the first time, the biological activities of four-carbon-atom bridged classical antifolates on dihydrofolate reductase (DHFR), thymidylate synthase (TS), and... -
16-Aza-<i>ent</i>-beyerane and 16-Aza-<i>ent</i>-trachylobane: Potent Mechan...
The secondary ent-beyeran-16-yl carbocation (7) is a key branch point intermediate in mechanistic schemes to rationalize the cyclic structures of many tetra- and pentacyclic...
