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MRI of trunk muscles and motor and respiratory function in patients with myot...
Abstract Background Myotonic Dystrophy 1 (DM1) causes progressive myopathy of extremity muscles. DM1 may also affect muscles of the trunk. The aim of this study was to... -
Perioperative cerebrospinal fluid and plasma inflammatory markers after ortho...
Abstract Background Postoperative delirium is prevalent in older patients and associated with worse outcomes. Recent data in animal studies demonstrate increases in inflammatory... -
Advanced paternal age as a risk factor for neurodevelopmental disorders: a tr...
Abstract Advanced paternal age (APA) is a risk factor for several neurodevelopmental disorders, including autism and schizophrenia. The potential mechanisms conferring this risk... -
Eye Biometry Using Quantitatve 3-D OCT
Cataracts cause the crystalline lens of the eye to progressively lose its transparency, which decreases vision. It is one of the major causes of vision loss in our aging... -
Pleural effusion from intrathoracic migration of a ventriculo-peritoneal shun...
Abstract Background Pleural effusion is a rare complication of ventriculo-peritoneal (VP) cerebrospinal fluid (CSF) shunting and its diagnosis is difficult in patients with... -
Autonomic nervous system response to remote ischemic conditioning: heart rate...
Abstract Background Remote ischemic conditioning (RIC) is a procedure applied in a limb for triggering endogenous protective pathways in distant organs, namely brain or heart.... -
Excessive carbohydrate consumption and body mass index: the risk factors for ...
Abstract Background Prader-Willi syndrome (PWS) is commonly associated with severe obesity and type 2 diabetes mellitus (T2DM) and is caused by excessive eating. Only very few... -
Cluster-randomized, controlled evaluation of a teacher led multi factorial sc...
Abstract Background The aim of this cluster-randomised, controlled study was to examine whether a teacher-led multifactorial back education programme could improve back pain in... -
Ca2+ in the dorsal raphe nucleus promotes wakefulness via endogenous sleep-wa...
Abstract Serotonergic neurons in the dorsal raphe nucleus (DRN) are involved in the control of sleep-wake states. Our previous studies have indicated that calcium (Ca2+)... -
Comparative analyses of the in vivo induction and transmission of α-synuclein...
Abstract α-synuclein (αS) is the major component of several types of brain pathological inclusions that define neurodegenerative diseases termed synucleinopathies. Central... -
Nanomedicine-driven neuropathic pain relief in a rat model is associated with...
Abstract We explored the immune neuropathology underlying multi-day relief from neuropathic pain in a rat model initiated at the sciatic nerve, by using a nanoemulsion-based... -
Resveratrol mediates mechanical allodynia through modulating inflammatory res...
Abstract Background Neuropathic pain (NeuP) is a chronic and challenging clinical problem, with little effective treatment. Resveratrol has shown neuroprotection by inhibiting... -
Differential expression of E-type prostanoid receptors 2 and 4 in microglia s...
Abstract Background Cyclooxygenase-2 (COX-2) is induced under inflammatory conditions, and prostaglandin E2 (PGE2) is one of the products of COX activity. PGE2 has pleiotropic... -
Evaluation of EMG pattern recognition for upper limb prosthesis control: a ca...
Abstract Background Although electromyogram (EMG) pattern recognition (PR) for multifunctional upper limb prosthesis control has been reported for decades, the clinical benefits... -
Peripheral cathepsin L inhibition induces fat loss in C. elegans and mice thr...
Abstract Background Cathepsin L and some other cathepsins have been implicated in the development of obesity in humans and mice. The functional inactivation of the proteases... -
iNOS is not responsible for RyR1 S-nitrosylation in mdx mice with truncated d...
Abstract Background Previous research indicated that nitric oxide synthase (NOS) is the key molecule for S-nitrosylation of ryanodine receptor 1 (RyR1) in DMD model mice (mdx... -
Immediate effects of a lumbar spine manipulation on pain sensitivity and post...
Abstract Background According to the American Physical Therapy Association, there is strong evidence to show that vertebral mobilization and manipulation procedures can be used... -
cAMP- and cGMP-elevating agents inhibit GPIbα-mediated aggregation but not GP...
Abstract Background The glycoprotein (GP) Ib-IX-V complex is a unique platelet plasma membrane receptor, which is essential for platelet adhesion and thrombus formation. GPIbα,... -
Tonic ATP-mediated growth suppression in peripheral nerve glia requires arres...
Abstract Normal Schwann cells (SCs) are quiescent in adult nerves, when ATP is released from the nerve in an activity dependent manner. We find that suppressing nerve activity... -
Factors influencing decision regret regarding placement of a PEG among substi...
Abstract Background A tube feeding decision aid designed at the Ottawa Health Research Institute was specifically created for substitute decision-makers who must decide whether...
