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Design, synthesis and biological activity of hydroxybenzoic acid ester conjug...
Abstract We prepared 16 novel hydroxybenzoic acid ester conjugates of phenazine-1-carboxylic acid (PCA) and investigated their biological activity. Most of the synthesized... -
Tonic ATP-mediated growth suppression in peripheral nerve glia requires arres...
Abstract Normal Schwann cells (SCs) are quiescent in adult nerves, when ATP is released from the nerve in an activity dependent manner. We find that suppressing nerve activity... -
Measurement of plasma norepinephrine and 3,4-dihydroxyphenylglycol: method de...
Abstract Objective Norepinephrine (NE), a sympathetic neurotransmitter, is often measured in plasma as an index of sympathetic activity. To better understand NE dynamics, it is... -
Effect of methanol extract of Salviae miltiorrhizae Radix in high-fat diet-in...
Abstract Background The dried root of Salvia miltiorrhiza, Salviae miltiorrhizae Radix (SR), is one of the most popular medicinal herbs in Asian countries such as China and... -
Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer
Abstract Background Understanding cell signaling pathways that contribute to metastatic colon cancer is critical to risk stratification in the era of personalized therapeutics.... -
Synthesis and insecticidal activity of diacylhydrazine derivatives containing...
Abstract Background The diacylhydrazine derivatives have attracted considerable attention in recently years due to their simple structure, low toxicity, and high insecticidal... -
Association of plasma soluble CD14 level with asthma severity in adults: a ca...
Abstract Background Soluble CD14 (sCD14) shedding from CD14 could regulate T lymphocyte activation and function, which has implicated in the pathogenesis of bronchial asthma.... -
TNFAIP3 is required for FGFR1 activation-promoted proliferation and tumorigen...
Abstract Background Although ductal carcinoma in situ (DCIS) is a non-invasive breast cancer, many DCIS lesions may progress to invasive cancer and the genes and pathways... -
The use of Euphorbia hirta L. (Euphorbiaceae) in diarrhea and constipation in...
Abstract Background Euphorbia hirta (Linn) family Euphorbiaceae has been used in indigenous system of medicine for the treatment of gastrointestinal disorders. This study was... -
Astragaloside IV inhibits lung cancer progression and metastasis by modulatin...
Abstract Background Accumulating evidence suggests that M2-polarized tumor-associated macrophages (TAMs) play an important role in cancer progression and metastasis, making M2... -
Efficacy and safety of ipratropium bromide/albuterol compared with albuterol ...
Abstract Background Many patients with asthma require frequent rescue medication for acute symptoms despite appropriate controller therapies. Thus, determining the most... -
Interactions between glycopyrronium and indacaterol on cholinergic neurotrans...
Abstract Background Muscarinic-receptor antagonists and β-adrenoceptor agonists are used, alone or in combination, as first-line treatment for chronic obstructive pulmonary... -
IDAAPM: integrated database of ADMET and adverse effects of predictive modeli...
Abstract Background The disposition of a pharmaceutical compound within an organism, i.e. its Absorption, Distribution, Metabolism, Excretion, Toxicity (ADMET) properties and... -
dedup_wf_001--4c8d338775fd0fc8ae9b0c7df2e327de
Team-based learning (TBL) is gradually being integrated into Chinese medical education. This study reports its current application status in Chinese medical schools, as well as... -
Breast milk DHA levels may increase after informing women: a community-based ...
Abstract Background Docosahexaenoic acid (DHA), an omega-3 fatty acid found in breast milk, has many health benefits for both mother and baby. A 2007 meta-analysis found U.S.... -
A principal components method constrained by elementary flux modes: analysis ...
Abstract Background Non-negative linear combinations of elementary flux modes (EMs) describe all feasible reaction flux distributions for a given metabolic network under the... -
Transcriptional and physiological analyses of Fe deficiency response in maize...
Abstract Background Under limited iron (Fe) availability maize, a Strategy II plant, improves Fe acquisition through the release of phytosiderophores (PS) into the rhizosphere... -
The cotton GhWIN2 gene activates the cuticle biosynthesis pathway and influen...
Abstract Background Metabolic pathways are interconnected and yet relatively independent. Genes involved in metabolic modules are required for the modules to run. Study of the... -
Regulation of platelet-activating factor-mediated interleukin-6 promoter acti...
Abstract Background An underlying state of inflammation is thought to be an important cause of cardiovascular disease. Among cells involved in the early steps of... -
Young adult non-smokers’ exposure to real-world tobacco marketing: results of...
Abstract Background The aims of this pilot study were to assess and characterize non-current smoking young adults’ exposure to tobacco marketing through an ecological momentary...
