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Genes targeted by the Hedgehog-signaling pathway can be regulated by Estrogen...
Abstract Background Nuclear receptor family member, Estrogen related receptor β, and the Hedgehog signal transduction pathway are both reported to relate to tumorigenesis and... -
The whole - genome expression analysis of peripheral blood mononuclear cells ...
Abstract Background Up to 30 % of adults with severe asthma are hypersensitive to aspirin and no unambiguous theory exists which provides a satisfactory explanation for the... -
M1-like tumor-associated macrophages activated by exosome-transferred THBS1 p...
Abstract Background Treatment strategies targeting tumor-associated macrophages (TAMs) have been proposed in cancer areas. The functional alterations of macrophages in the... -
cAMP- and cGMP-elevating agents inhibit GPIbα-mediated aggregation but not GP...
Abstract Background The glycoprotein (GP) Ib-IX-V complex is a unique platelet plasma membrane receptor, which is essential for platelet adhesion and thrombus formation. GPIbα,... -
Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrat...
Abstract Background Zyflamend, a blend of herbal extracts, effectively inhibits tumor growth using preclinical models of castrate-resistant prostate cancer mediated in part by... -
Effects of cigarette smoke on barrier function and tight junction proteins in...
Abstract Background Airway epithelial barrier function is maintained by the formation of tight junctions (TJs) and adherens junctions (AJs). Inhalation of cigarette smoke causes... -
Speech-guided breathing retraining in asthma: a randomised controlled crossov...
Abstract Background Breathing retraining techniques have received increased attention in the management of asthma, because there is growing evidence of the usefulness of such... -
Cord blood DNA methylation reflects cord blood C-reactive protein levels but ...
Abstract Background Prenatal inflammation has been proposed as an important mediating factor in several adverse pregnancy outcomes. C-reactive protein (CRP) is an inflammatory... -
Asthmatic bronchial epithelial cells promote the establishment of a Hyalurona...
Abstract Background Airway inflammation is a hallmark of asthma. Alterations in extracellular matrix (ECM) hyaluronan (HA) content have been shown to modulate the recruitment... -
Liraglutide ameliorates beta-cell function, alleviates oxidative stress and i...
Abstract Background The prevalence of type 2 diabetes in youth is escalating rapidly. We aimed to evaluate the effects of liraglutide on beta-cell function, metabolic... -
Prolactin blocks the expression of receptor activator of nuclear factor κB li...
Abstract Background Prolactin (PRL) reduces joint inflammation, pannus formation, and bone destruction in rats with polyarticular adjuvant-induced arthritis (AIA). Here, we... -
Heat shock pretreatment improves mesenchymal stem cell viability by heat shoc...
Abstract Background Bone marrow mesenchymal stem cells (BMSCs) can partially repair chemotherapy-induced ovarian damage. However, low survival rate after transplantation hampers... -
Fibrinolysis protease receptors promote activation of astrocytes to express p...
Abstract Background Astrocytes contribute to the crosstalk that generates chronic neuro-inflammation in neurological diseases; however, compared with microglia, astrocytes... -
Evidence of metachronous development of ovarian teratomas: a case report of b...
Abstract Background Mature cystic teratomas are usually found in the ovaries. They are bilateral in 10 to 15% of cases and multiple cystic teratomas may be present in one ovary.... -
Impaired type I interferon regulation in the blood transcriptome of recurrent...
Abstract Background Asthma exacerbations are an important cause of morbidity in asthma. Respiratory infections are often involved in asthma exacerbations in both children and... -
Role of mesenchymal stem cells, their derived factors, and extracellular vesi...
Abstract Liver failure is a severe clinical syndrome with a poor prognosis. Mesenchymal stem cell (MSC) transplantation has emerged as a new intervention in treating liver... -
Epigenetic regulation of transcription factor promoter regions by low-dose ge...
Abstract Background The phytoestrogen, genistein at low doses nongenomically activates mitogen-activated protein kinase p44/42 (MAPKp44/42) via estrogen receptor alpha (ERα)... -
VEGF-121 plasma level as biomarker for response to anti-angiogenetic therapy ...
Abstract Background Vascular endothelial growth factor (VEGF) isoforms, particularly the diffusible VEGF-121, could play a major role in the response of recurrent glioblastoma... -
JMJD2C promotes colorectal cancer metastasis via regulating histone methylati...
Abstract Background Our previous work demonstrated that lncRNA-MALAT1 was overexpressed in recurrent colorectal cancer (CRC) and metastatic sites in post-surgical patients.... -
Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-m...
Impairment in macroautophagy/autophagy flux and inflammasome activation are common characteristics of nonalcoholic steatohepatitis (NASH). Considering the lack of approved...
