-
Evaluating parents’ decisions about next-generation sequencing for their chil...
Abstract Background Using next-generation sequencing (NGS) in newborn screening (NBS) could expand the number of genetic conditions detected pre-symptomatically, simultaneously... -
Resveratrol mediates mechanical allodynia through modulating inflammatory res...
Abstract Background Neuropathic pain (NeuP) is a chronic and challenging clinical problem, with little effective treatment. Resveratrol has shown neuroprotection by inhibiting... -
Pain is a common problem in patients with ILD
Abstract Background As it is less known about the prevalence and characteristics of pain in the patients with interstitial lung disease (ILD), this paper aims at determining the... -
Biopsy vs. extensive resection for first recurrence of glioblastoma: is a pro...
Abstract Background Glioblastoma is an aggressive and almost universally fatal tumor. The prognosis at the time of recurrence has generally been poor, with overall survival... -
Peripheral neuropathy in metachromatic leukodystrophy: Current status and fut...
Abstract Metachromatic leukodystrophy (MLD) is an autosomal recessively inherited metabolic disease characterized by deficient activity of the lysosomal enzyme arylsulfatase A.... -
Expression of ACE2 and a viral virulence-regulating factor CCN family member ...
Abstract It has been reported that coronavirus disease 2019 (COVID-19) causes not only pneumonia but also systemic inflammations including central nervous system (CNS)... -
Pancreatic cancer-initiating cell exosome message transfer into noncancer-ini...
Abstract Background Cancer-initiating cell (CIC) exosomes (CIC-TEX) are suggested reprogramming Non-CIC. Mode of message transfer and engagement of CIC-markers being disputed,... -
Chronic pain after groin hernia repair: pain characteristics and impact on qu...
Abstract Background Chronic postsurgical pain (CPSP) after hernia repair research has mainly relied on unconfirmed self-reporting. We aimed to describe confirmed CPSP incidence,... -
Comparison of gray matter volume between migraine and "strict-criteria" tensi...
Abstract Background Despite evidently distinct symptoms, tension-type headache (TTH) and migraine are highly comorbid and exhibit many similarities in clinical practice. The... -
Modeling leukocyte trafficking at the human blood-nerve barrier in vitro and ...
Abstract Peripheral neuroinflammation is characterized by hematogenous mononuclear leukocyte infiltration into peripheral nerves. Despite significant clinical knowledge,... -
Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption t...
Abstract Background Systemic inflammation has been linked to synapse loss and cognitive decline in human patients and animal models. A role for microglial release of... -
A neuroligin-3 mutation implicated in autism causes abnormal aggression and i...
Abstract Background Aggression is common in patients with autism spectrum disorders (ASD) along with the core symptoms of impairments in social communication and repetitive... -
3D differential phase contrast microscopy
We demonstrate 3D phase and absorption recovery from partially coherent intensity images captured with a programmable LED array source. Images are captured through-focus with... -
Not only dominant, not only optic atrophy: expanding the clinical spectrum as...
Abstract Background Heterozygous mutations in OPA1 are a common cause of autosomal dominant optic atrophy, sometimes associated with extra-ocular manifestations. Few cases... -
Stratified analyses of genome wide association study data reveal haplotypes f...
Abstract Background Genome Wide Association Studies (GWAS) have been conducted to identify genes and pathways involved in development of opioid use disorder. This study extends... -
Epigenetic suppression of liver X receptor β in anterior cingulate cortex by ...
Abstract Background Liver X receptors (LXRs), including LXRα and LXRβ, are key regulators of transcriptional programs for both cholesterol homeostasis and inflammation in the... -
Ready, Set, Change! Development and usability testing of an online readiness ...
Abstract Background To address challenges related to selecting a valid, reliable, and appropriate readiness assessment measure in practice, we developed an online decision... -
Expression and activity of the calcitonin receptor family in a sample of prim...
Abstract Background Glioblastoma (GBM) is the most common and aggressive type of primary brain cancer. With median survival of less than 15â months, identification and... -
Suppression of MyD88-dependent signaling alleviates neuropathic pain induced ...
Abstract Background MyD88 is the adaptor protein of MyD88-dependent signaling pathway of TLRs and IL-1 receptor and regulates innate immune response. However, it was not clear... -
Crosstalk between NFκB-dependent astrocytic CXCL1 and neuron CXCR2 plays a ro...
Abstract Background Despite accumulating evidence on the role of glial cells and their associated chemicals in mechanisms of pain, few studies have addressed the potential role...
