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Resveratrol mediates mechanical allodynia through modulating inflammatory res...
Abstract Background Neuropathic pain (NeuP) is a chronic and challenging clinical problem, with little effective treatment. Resveratrol has shown neuroprotection by inhibiting... -
Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption t...
Abstract Background Systemic inflammation has been linked to synapse loss and cognitive decline in human patients and animal models. A role for microglial release of... -
Epigenetic suppression of liver X receptor β in anterior cingulate cortex by ...
Abstract Background Liver X receptors (LXRs), including LXRα and LXRβ, are key regulators of transcriptional programs for both cholesterol homeostasis and inflammation in the... -
Suppression of MyD88-dependent signaling alleviates neuropathic pain induced ...
Abstract Background MyD88 is the adaptor protein of MyD88-dependent signaling pathway of TLRs and IL-1 receptor and regulates innate immune response. However, it was not clear... -
NADPH oxidases as potential pharmacological targets against increased seizure...
Abstract Background Systemic inflammation associated with sepsis can induce neuronal hyperexcitability, leading to enhanced seizure predisposition and occurrence. Brain... -
The pentose phosphate pathway regulates chronic neuroinflammation and dopamin...
Abstract Background Metabolic dysfunction and neuroinflammation are increasingly implicated in Parkinson’s disease (PD). The pentose phosphate pathway (PPP, a metabolic pathway... -
MicroRNA-181a as novel liquid biopsy marker of central nervous system involve...
Abstract Background Refractory central nervous system (CNS) involvement is among the major causes of therapy failure in childhood acute leukemia. Applying contemporary... -
Epidermal growth factor prevents APOE4 and amyloid-beta-induced cognitive and...
Abstract Cerebrovascular (CV) dysfunction is emerging as a critical component of Alzheimer’s disease (AD), including altered CV coverage. Angiogenic growth factors (AGFs) are... -
Pellino1 regulates neuropathic pain as well as microglial activation through ...
Abstract Background Spinal cord microglia plays a crucial role in the pathogenesis of neuropathic pain. However, the mechanisms underlying spinal microglial activation during... -
Oxysterol levels and metabolism in the course of neuroinflammation: insights ...
Abstract Background Oxysterols are cholesterol derivatives that have been suggested to play a role in inflammatory diseases such as obesity, atherosclerosis, or... -
Low back pain and limitations of daily living in Asia: longitudinal findings ...
Abstract Background Low back pain (LBP) is a major cause of disability throughout the world. However, longitudinal evidence to relate low back pain and functional limitations is... -
Global Hypoxia-Ischemia Induced Inflammation and Structural Changes in the Pr...
Abstract Perinatal asphyxia, a condition of impaired gas exchange during birth, leads to fetal hypoxia-ischemia (HI) and is associated with postnatal adverse outcomes including... -
Heme oxygenase-1 promoter region (GT)n polymorphism associates with increased...
Abstract Background Heme oxygenase-1 (HO-1) is a critical cytoprotective enzyme that limits oxidative stress, inflammation, and cellular injury within the central nervous system... -
HIV induces expression of complement component C3 in astrocytes by NF-κB-depe...
Abstract Background Abnormal activation of the complement system contributes to some central nervous system diseases but the role of complement in HIV-associated neurocognitive... -
Paclitaxel-activated astrocytes produce mechanical allodynia in mice by relea...
Abstract Background Paclitaxel is a widely used and potent chemotherapeutic agent for the treatment of cancer. However, patients receiving paclitaxel often develop an acute pain... -
Do fragments and glycosylated isoforms of alpha-1-antitrypsin in CSF mirror s...
Abstract Background Post-translational modifications (PTMs) generate a tremendous protein diversity from the ~ 20,000 protein-coding genes of the human genome. In chronic pain... -
Intermittent peripheral exposure to lipopolysaccharide induces exploratory be...
Abstract Background Consecutive peripheral immune challenges can modulate the responses of brain resident microglia to stimuli. High-fat diet (HFD) intake has been reported to... -
The preventive effect of resiniferatoxin on the development of cold hypersens...
Abstract Background Resiniferatoxin (RTX) is a potent analog of capsaicin and activates transient receptor potential (TRP) vanilloid type (TRPV) 1. In the current study, we... -
Concordance analysis of microarray studies identifies representative gene exp...
Abstract Background As the popularity of transcriptomic analysis has grown, the reported lack of concordance between different studies of the same condition has become a growing... -
Selective suppression of the JNK-MMP2/9 signal pathway by tetramethylpyrazine...
Abstract Background Activated astrocytes release matrix metalloproteinase-2/9 (MMP-2/9) to induce central sensitization and maintain neuropathic pain. However, the mechanisms...
