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Development of a small panel of SNPs to infer ancestry in Chileans that disti...
Abstract Background Current South American populations trace their origins mainly to three continental ancestries, i.e. European, Amerindian and African. Individual variation in... -
Classical and Bayesian random-effects meta-analysis models with sample qualit...
Abstract Background Random-effects (RE) models are commonly applied to account for heterogeneity in effect sizes in gene expression meta-analysis. The degree of heterogeneity... -
tmap: an integrative framework based on topological data analysis for populat...
Abstract Untangling the complex variations of microbiome associated with large-scale host phenotypes or environment types challenges the currently available analytic methods.... -
Accuracy assessment of fusion transcript detection via read-mapping and de no...
Abstract Background Accurate fusion transcript detection is essential for comprehensive characterization of cancer transcriptomes. Over the last decade, multiple bioinformatic... -
Inflammation-related gene polymorphisms associated with Parkinson’s disease: ...
Abstract Background Strong evidence supports the involvement of inflammation processes in the development and progression of Parkinson’s disease (PD), where increasingly... -
Efficiency of different strategies to mitigate ascertainment bias when using ...
Abstract Background Single nucleotide polymorphism (SNP) panels have been widely used to study genomic variations within and between populations. Methods of SNP discovery have... -
Probabilistic ancestry maps: a method to assess and visualize population subs...
Abstract Background Principal component analysis (PCA) is a standard method to correct for population stratification in ancestry-specific genome-wide association studies (GWASs)... -
Genetic model misspecification in genetic association studies
Abstract Objective The underlying model of the genetic determinant of a trait is generally not known with certainty a priori. Hence, in genetic association studies, a dominant... -
Extent of third-order linkage disequilibrium in a composite line of Iberian pigs
Abstract Background Previous studies on linkage disequilibrium have investigated second order linkage disequilibrium in animal and plant populations. The objective of this paper... -
Illumination uniformity assessment based on human vision
Assessing how uniform the light distribution is throughout an illuminated target is important in many applications, but traditional methods do not quantify the variability of... -
Association between ATM rs1801516 polymorphism and cancer susceptibility: a m...
Abstract Background Ataxia telangiectasia mutated (ATM) gene plays a key role in response to DNA lesions and is related to the invasion and metastasis of malignancy.... -
Genomic inbreeding coefficients based on the distribution of the length of ru...
Abstract Background The increasing availability of DNA markers provides new metrics of inbreeding based on single nucleotide polymorphisms (SNPs), i.e. molecular inbreeding or... -
In utero exposure to polychlorinated biphenyls is associated with decreased f...
Abstract Background Multiple studies have suggested a relationship between adult exposures to environmental organochlorines and fecundability. There is a paucity of data,... -
Comparison of estimators of variance for forest inventories with systematic s...
Background: Large area forest inventories often use regular grids (with a single random start) of sample locations to ensure a uniform sampling intensity across the space of the... -
Linkage analysis and QTL mapping in a tetraploid russet mapping population of...
Abstract Background Genome-wide single nucleotide polymorphism (SNP) markers coupled with allele dosage information has emerged as a powerful tool for studying complex traits in...
