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Scl-Ab reverts pro-osteoclastogenic signalling and resorption in estrogen def...
Abstract Background Neutralising antibodies to sclerostin (Scl-Ab) have shown significant potential to induce bone formation and decrease bone resorption, increase strength and... -
Long-term follow-up after scleral lens fixation in patients with Marfan syndrome
Abstract Background The dislocation of the crystalline lens is a common finding in patients with Marfan syndrome (MFS). Scleral intraocular lens (IOL) fixation is an accepted... -
Comparative analyses of the in vivo induction and transmission of α-synuclein...
Abstract α-synuclein (αS) is the major component of several types of brain pathological inclusions that define neurodegenerative diseases termed synucleinopathies. Central... -
Neuronal impairment following chronic Toxoplasma gondii infection is aggravat...
Abstract Background It has become increasingly evident that the immune and nervous systems are closely intertwined, relying on one another during regular homeostatic conditions.... -
The NuA4 acetyltransferase and histone H4 acetylation promote replication rec...
Abstract Background Histone acetylation plays an important role in DNA replication and repair because replicating chromatin is subject to dynamic changes in its structures.... -
Pervasive read-through transcription of T-DNAs is frequent in tobacco BY-2 ce...
Abstract Background Plant transformation via Agrobacterium tumefaciens is characterized by integration of commonly low number of T-DNAs at random positions in the genome. When... -
How much allopurinol does it take to get to target urate? Comparison of actua...
Abstract Objective Allopurinol dosing has frequently been limited based on creatinine clearance (CrCL), resulting in failure to achieve target serum urate (SU). The aim of this... -
Evaluating physical functioning in critical care: considerations for clinical...
Abstract The evaluation of physical functioning is valuable in the intensive care unit (ICU) to help inform patient recovery after critical illness, to identify patients who may... -
Associations within school-based same-sex friendship networks of children’s p...
Abstract Background Physical activity in children is associated with better physical and mental health but many children do not meet physical activity guidelines. Friendship... -
Building damage survey and microtremor measurements for the source region of ...
Abstract We performed a damage survey of buildings and carried out microtremor observations in the source region of the 2015 Gorkha earthquake. Our survey area spans the... -
Loop diuretic use in patients with AKI: different severity, different response
Loop diuretic use in patients with AKI: different severity, different response -
The dynamics of collective social behavior in a crowd controlled game
Abstract Despite many efforts, the behavior of a crowd is not fully understood. The advent of modern communication means has made it an even more challenging problem, as crowd... -
Low plasma neurofilament light levels associated with raised cortical microgl...
Abstract Background Plasma and cerebrospinal fluid levels of neurofilament light (NfL), a marker of axonal degeneration, have previously been reported to be raised in patients... -
Fluid status evaluation by inferior vena cava diameter and bioimpedance spect...
Abstract Background Evaluation of patient’s dry weight remains challenging in chronic hemodialysis (HD) especially in children. Inferior Vena Cava (IVC) measurement was reported... -
DNA replication dynamics of vole genome and its epigenetic regulation
Abstract Background The genome of some vole rodents exhibit large blocks of heterochromatin coupled to their sex chromosomes. The DNA composition and transcriptional activity of... -
High-throughput sequencing of small RNAs revealed the diversified cold-respon...
Abstract Background Cold stress is one of the most severe abiotic stresses affecting the banana production. Although some miRNAs have been identified, little is known about the... -
RNA polymerase II depletion promotes transcription of alternative mRNA species
Abstract Background Cells respond to numerous internal and external stresses, such as heat, cold, oxidative stress, DNA damage, and osmotic pressure changes. In most cases, the... -
Is being a regular player with fewer teammates associated with musculoskeleta...
Abstract Background Musculoskeletal pain (MSP) is a commonly reported symptom in youth sports players. Some sports-related risk factors have been reported, but previous studies... -
Can terminators be used as insulators into yeast synthetic gene circuits?
Abstract Background In bacteria, transcription units can be insulated by placing a terminator in front of a promoter. In this way promoter leakage due to the read-through from... -
A cluster randomized controlled trial comparing the effectiveness of an indiv...
Abstract Background Most adolescents do not meet the recommendations for physical activity (PA) of at least 1 h per day. Individual planning (IP) interventions, including...
