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Reduced expression of miR-146a in human bronchial epithelial cells alters neu...
Abstract Background The role of miRNAs in the pathogenesis and determining the phenotypes of asthma is not fully elucidated. miR-146a has been previously shown to suppress... -
A randomized, 29-day, dose-ranging, efficacy and safety study of daprodustat,...
Abstract Background Daprodustat is a hypoxia-inducible factor-prolyl hydroxylase inhibitor currently being investigated as a treatment for anemia of chronic kidney disease (CKD)... -
Development of a new promoter to avoid the silencing of genes in the producti...
Abstract Background The production of recombinant proteins in mammalian cell lines is one of the most important areas in biopharmaceutical industry. Viral transcriptional... -
Neutrophil extracellular traps induce aggregation of washed human platelets i...
Abstract Background The release of neutrophil extracellular traps (NETs), a mesh of DNA, histones and neutrophil proteases from neutrophils, was first demonstrated as a host... -
Characterizing and prognosticating chronic lymphocytic leukemia in the elderl...
Abstract Background Median age at diagnosis of patients with chronic lymphocytic leukemia (CLL) is > 70 years. However, the majority of clinical trials do not reflect the... -
Sexual dimorphism in the incidence of human cancers
Abstract Background Sex differences in the incidences of cancers become a critical issue in both cancer research and the development of precision medicine. However, details in... -
The roles of neutrophil serine proteinases in idiopathic inflammatory myopathies
Abstract Background Dermatomyositis and polymyositis are the best known idiopathic inflammatory myopathies (IIMs). Classic histopathologic findings include the infiltration of... -
Role of mesenchymal stem cells, their derived factors, and extracellular vesi...
Abstract Liver failure is a severe clinical syndrome with a poor prognosis. Mesenchymal stem cell (MSC) transplantation has emerged as a new intervention in treating liver... -
MicroRNA-181a as novel liquid biopsy marker of central nervous system involve...
Abstract Background Refractory central nervous system (CNS) involvement is among the major causes of therapy failure in childhood acute leukemia. Applying contemporary... -
Low-dose lymphocyte immunotherapy rebalances the peripheral blood Th1/Th2/Tre...
Abstract Background The published results regarding lymphocytes immunotherapy for unexplained recurrent miscarriage (uRM) patients are conflicting due to different screening... -
Failure of remission induction by glucocorticoids alone or in combination wit...
Abstract Background The aim of this study was to assess the outcomes of remission induction in patients with IgG4-related disease (IgG4-RD) in our cohort, and to investigate the... -
Single nucleotide polymorphisms in apoptosis pathway are associated with resp...
Abstract Background The mechanism of action of imatinib is known to involve the Fas-mediated apoptosis pathway. Consequently inter-individual variations in this apoptosis... -
Thrombin-induced, TNFR-dependent miR-181c downregulation promotes MLL1 and NF...
Abstract Background Controlling thrombin-driven microglial activation may serve as a therapeutic target for intracerebral hemorrhage (ICH). Here, we investigated microRNA... -
Human Herpesvirus-6 corneal Endotheliitis after intravitreal injection of Ran...
Abstract Background To report the first case of human herpesvirus-6 (HHV-6) corneal endotheliitis that developed after intravitreal ranibizumab injections. Case presentation A... -
Umbilical cord/placenta-derived mesenchymal stem cells inhibit fibrogenic act...
Abstract Background The lack of anti-fibrotic agents targeting intestinal fibrosis is a large unmet need in inflammatory bowel diseases, including Crohn’s disease and ulcerative... -
CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development
Abstract Background Single nucleotide polymorphisms (SNPs) in chitinase 3-like 1 (CHI3L1), the gene encoding YKL-40, and increased serum YKL-40 levels are associated with severe... -
MICA immune complex formed with alpha 3 domain-specific antibody activates hu...
Abstract Background One of the mechanisms by which tumors evade immune surveillance is through shedding of the major histocompatibility complex (MHC) class I chain-related... -
Inflammatory anemia-associated parameters are related to 28-day mortality in ...
Abstract Background Anemia is one of the most common complications of sepsis. Sepsis-related anemia is associated mainly with inflammation. We aimed to observe the changes in... -
Platelet-derived exosomes promote neutrophil extracellular trap formation dur...
Abstract Background Platelets have been demonstrated to be potent activators of neutrophil extracellular trap (NET) formation during sepsis. However, the mediators and molecular... -
Dose-finding evaluation of once-daily treatment with olodaterol, a novel long...
Abstract Background Olodaterol is a novel, inhaled long-acting β2-agonist (LABA) with >24-h duration of action investigated in asthma and chronic obstructive pulmonary...
