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Genes targeted by the Hedgehog-signaling pathway can be regulated by Estrogen...
Abstract Background Nuclear receptor family member, Estrogen related receptor β, and the Hedgehog signal transduction pathway are both reported to relate to tumorigenesis and... -
Differential expression of E-type prostanoid receptors 2 and 4 in microglia s...
Abstract Background Cyclooxygenase-2 (COX-2) is induced under inflammatory conditions, and prostaglandin E2 (PGE2) is one of the products of COX activity. PGE2 has pleiotropic... -
EWS and FUS bind a subset of transcribed genes encoding proteins enriched in ...
Abstract Background FUS (TLS) and EWS (EWSR1) belong to the FET-protein family of RNA and DNA binding proteins. FUS and EWS are structurally and functionally related and... -
Pervasive read-through transcription of T-DNAs is frequent in tobacco BY-2 ce...
Abstract Background Plant transformation via Agrobacterium tumefaciens is characterized by integration of commonly low number of T-DNAs at random positions in the genome. When... -
Pathway activity profiling of growth factor receptor network and stemness pat...
Abstract Background Gene expression profiling of rare cancers has proven challenging due to limited access to patient materials and requirement of intact, non-degraded RNA for... -
Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mic...
Abstract Background Nonalcoholic fatty liver disease is one of the most common liver diseases in the world and is a typical hepatic manifestation of metabolic syndrome which is... -
Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrat...
Abstract Background Zyflamend, a blend of herbal extracts, effectively inhibits tumor growth using preclinical models of castrate-resistant prostate cancer mediated in part by... -
Characterization of novel Bovine Leukemia Virus (BLV) antisense transcripts b...
Abstract Background Bovine Leukemia Virus (BLV) is a deltaretrovirus closely related to the Human T cell leukemia virus-1 (HTLV-1). Cattle are the natural host of BLV where it... -
Production of human pro-relaxin H2 in the yeast Pichia pastoris
Abstract Background Initially known as the reproductive hormone, relaxin was shown to possess other therapeutically useful properties that include extracellular matrix... -
Characterisation of a niche-specific excretory–secretory peroxiredoxin from t...
Abstract Background The primary cause of parasitic gastroenteritis in small ruminants in temperate regions is the brown stomach worm, Teladorsagia circumcincta. Host immunity to... -
Past and new challenges for malaria control and elimination: the role of oper...
Abstract This meeting report presents the outcomes of a workshop held in Bangkok on December 1st 2014, where the following challenges were discussed: the threat of resistance to... -
Regulation of platelet-activating factor-induced interleukin-8 expression by ...
Abstract Background Platelet-activating factor (PAF) is a potent lipid mediator whose involvement in the onset and progression of atherosclerosis is mediated by, among others,... -
Identification and validation of a Schistosoma japonicum U6 promoter
Abstract Background RNA polymerase III promoters have been widely used to express short hairpin-RNA (shRNA), microRNA (miRNA), and small guide RNA (sgRNA) in gene functional... -
Reduced BRCA1 transcript levels in freshly isolated blood leukocytes from BRC...
Abstract Background BRCA1 mutation carriers face a high lifetime risk of developing both breast and ovarian cancer. Haploinsufficiency is thought to predispose these women to... -
Signal transducer and activator of transcription STAT5 is recruited to c-Myc ...
Abstract Background c-Myc has been proposed as a putative target gene of signal transducer and activator of transcription 5 (STAT5). No functional STAT5 binding site has been... -
Increased expression of dedicator-cytokinesis-10, caspase-2 and Synaptotagmin...
Abstract Background We aim to identify differentially expressed genes (DEGs) and its pathways associated with clinical activity of relapsing–remitting Multiple Sclerosis (RRMS).... -
Chromosomal integration vectors allowing flexible expression of foreign genes...
Abstract Background Campylobacter jejuni is a major cause of human gastroenteritis yet there is limited knowledge of how disease is caused. Molecular genetic approaches are... -
LDL in patients with subclinical hypothyroidism shows increased lipid peroxid...
Abstract Background Population-based studies have demonstrated that subclinical hypothyroidism (SCH) is an independent risk factor for atherosclerosis (OR = 1.9). However, this... -
Characteristics of functional enrichment and gene expression level of human p...
Abstract Background Transcriptional target genes show functional enrichment of genes. However, how many and how significantly transcriptional target genes include functional... -
Complex and dynamic transcriptional changes allow the helminth Fasciola gigan...
Abstract Background The tropical liver fluke, Fasciola gigantica causes fasciolosis, an important disease of humans and livestock. We characterized dynamic transcriptional...
