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EWS and FUS bind a subset of transcribed genes encoding proteins enriched in ...
Abstract Background FUS (TLS) and EWS (EWSR1) belong to the FET-protein family of RNA and DNA binding proteins. FUS and EWS are structurally and functionally related and... -
Pervasive read-through transcription of T-DNAs is frequent in tobacco BY-2 ce...
Abstract Background Plant transformation via Agrobacterium tumefaciens is characterized by integration of commonly low number of T-DNAs at random positions in the genome. When... -
TSS seq based core promoter architecture in blood feeding Tsetse fly (Glossin...
Abstract Background Transcription initiation regulation is mediated by sequence-specific interactions between DNA-binding proteins (transcription factors) and cis-elements,... -
IgA, albumin, and eosinopenia as early indicators of cytomegalovirus infectio...
Abstract Background Cytomegalovirus (CMV) infection can significantly complicate and worsen the condition of acute severe ulcerative colitis (UC) patients. We aimed to explore... -
Characterization of novel Bovine Leukemia Virus (BLV) antisense transcripts b...
Abstract Background Bovine Leukemia Virus (BLV) is a deltaretrovirus closely related to the Human T cell leukemia virus-1 (HTLV-1). Cattle are the natural host of BLV where it... -
Changes of the glutathione redox system during the weaning transition in pigl...
Abstract Background Weaning is known to result in barrier dysfunction and villus atrophy in the immediate post-weaning phase, and the magnitude of these responses is... -
Regulation of platelet-activating factor-induced interleukin-8 expression by ...
Abstract Background Platelet-activating factor (PAF) is a potent lipid mediator whose involvement in the onset and progression of atherosclerosis is mediated by, among others,... -
Specificity versus redundancy in the RAP2.4 transcription factor family of Ar...
Abstract Background The Arabidopsis ERFIb / RAP2.4 transcription factor family consists of eight members with highly conserved DNA binding domains. Selected members have been... -
Disruption of zinc transporter ZnT3 transcriptional activity and synaptic ves...
Abstract Background Huntington’s disease (HD) is a neurodegenerative disease that involves a complex combination of psychiatric, cognitive and motor impairments. Synaptic... -
Drosophila Ref1/ALYREF regulates transcription and toxicity associated with A...
Abstract RNA-binding proteins (RBPs) are associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the underlying disease mechanisms remain... -
Identification and validation of a Schistosoma japonicum U6 promoter
Abstract Background RNA polymerase III promoters have been widely used to express short hairpin-RNA (shRNA), microRNA (miRNA), and small guide RNA (sgRNA) in gene functional... -
Signal transducer and activator of transcription STAT5 is recruited to c-Myc ...
Abstract Background c-Myc has been proposed as a putative target gene of signal transducer and activator of transcription 5 (STAT5). No functional STAT5 binding site has been... -
Independent modulation of individual genomic component transcription and a ci...
Abstract Background The genome of Banana bunchy top virus (BBTV) consists of at least six circular, single-stranded DNA components of ~ 1 kb in length. Some BBTV isolates may... -
Characteristics of functional enrichment and gene expression level of human p...
Abstract Background Transcriptional target genes show functional enrichment of genes. However, how many and how significantly transcriptional target genes include functional... -
RNA polymerase II depletion promotes transcription of alternative mRNA species
Abstract Background Cells respond to numerous internal and external stresses, such as heat, cold, oxidative stress, DNA damage, and osmotic pressure changes. In most cases, the... -
Can terminators be used as insulators into yeast synthetic gene circuits?
Abstract Background In bacteria, transcription units can be insulated by placing a terminator in front of a promoter. In this way promoter leakage due to the read-through from... -
Transcriptional activation of USP16 gene expression by NFκB signaling
Abstract Ubiquitin Specific Peptidase 16 (USP16) has been reported to contribute to somatic stem-cell defects in Down syndrome. However, how this gene being regulated is largely... -
A CLCA regulatory protein present in the chemosensory cilia of olfactory sens...
Abstract Background CLCA is a family of metalloproteases that regulate Ca2+-activated Cl− fluxes in epithelial tissues. In HEK293 cells, CLCA1 promotes membrane expression of an... -
The HDAC6/APOBEC3G complex regulates HIV-1 infectiveness by inducing Vif auto...
Abstract Background Human immunodeficiency virus type 1 (HIV-1) has evolved a complex strategy to overcome the immune barriers it encounters throughout an organism thanks to its... -
eEF1Bγ binds the Che-1 and TP53 gene promoters and their transcripts
Abstract Background We have previously shown that the eukaryotic elongation factor subunit 1B gamma (eEF1Bγ) interacts with the RNA polymerase II (pol II) alpha-like subunit “C”...
