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Aberrant activation of CYR61 enhancers in colorectal cancer development
Abstract Background High expression of secreted matricellular protein cysteine-rich 61 (CYR61) correlates with poor prognosis in colorectal cancer (CRC). Aberrant enhancer... -
Glossogyne tenuifolia (Hsiang-ju) extract suppresses T cell activation by inh...
Abstract Background Glossogyne tenuifolia (GT) (Hsiang-ju) is a Chinese herbal medicine previously exhibited an anti-inflammatory activity. This study aimed to investigate the... -
A longitudinal study highlights shared aspects of the transcriptomic response...
Abstract Background Septic shock (SS) and cardiogenic shock (CS) are two types of circulatory shock with a different etiology. Several studies have described the molecular... -
Absolute quantification of terpenes in conifer-derived essential oils and the...
Abstract A simple, robust, and precise method for the absolute quantification of the terpenes α-pinene, camphene, β-pinene, 3-carene, limonene, bornyl acetate, β-caryophyllene,... -
Cancer-derived exosomal TRIM59 regulates macrophage NLRP3 inflammasome activa...
Abstract Background Exosomes are emerging as important mediators of the cross-talk between tumor cells and the microenvironment. The communication between tumor-derived exosomes... -
Kaiso differentially regulates components of the Notch signaling pathway in i...
Abstract Background In mammalian intestines, Notch signaling plays a critical role in mediating cell fate decisions; it promotes the absorptive (or enterocyte) cell fate, while... -
Soluble epoxide hydrolase modulates immune responses in activated astrocytes ...
Abstract Background Astrocyte activation is a common pathological feature in many brain diseases with neuroinflammation, and revealing the underlying mechanisms might shed light... -
Inactivation of the tight junction gene CLDN11 by aberrant hypermethylation m...
Abstract Background Aberrant hypermethylation of cellular genes is a common phenomenon to inactivate genes and promote tumorigenesis in nasopharyngeal carcinoma (NPC). Methods... -
ΗΙF1α, EGR1 and SP1 co-regulate the erythropoietin receptor expression under ...
Abstract Background Overexpression of erythropoietin (EPO) and EPO receptor (EPO-R) is associated with poor prognosis in non-small-cell lung carcinoma (NSCLC). Hypoxia, a potent... -
Umbilical cord/placenta-derived mesenchymal stem cells inhibit fibrogenic act...
Abstract Background The lack of anti-fibrotic agents targeting intestinal fibrosis is a large unmet need in inflammatory bowel diseases, including Crohn’s disease and ulcerative... -
Design and analysis of stably integrated reporters for inducible transgene ex...
Abstract Background Cytotoxic activity of T- and NK-cells can be efficiently retargeted against cancer cells using chimeric antigen receptors (CARs) and rTCRs. In the context of... -
Exosomal miR-9 inhibits angiogenesis by targeting MDK and regulating PDK/AKT ...
Abstract Background Exosomes are small vesicles containing a wide range of functional proteins, mRNA and miRNA. Exosomal miRNAs from cancer cells play crucial roles in mediating... -
Microglial Stimulation of Glioblastoma Invasion Involves Epidermal Growth Fac...
Abstract Glioblastoma multiforme is a deadly cancer for which current treatment options are limited. The ability of glioblastoma tumor cells to infiltrate the surrounding brain... -
HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activ...
Abstract Background Type 2 diabetes mellitus (T2DM) is a chronic metabolic dysfunction characterized by progressive insulin resistance and hyperglycaemia. Increased blood-brain... -
Choroidal structural changes correlate with severity of diabetic retinopathy ...
Abstract Background This study aims to investigate the choroidal thickness and choroidal vascular density parameters and their correlation with severity of diabetic retinopathy... -
Aryl hydrocarbon receptor-microRNA-212/132 axis in human breast cancer suppre...
Abstract Background MicroRNAs (miRNAs) are a class of short non-coding RNAs that pave a new avenue for understanding immune responses and cancer progression. Although the miRNAs... -
Effects of hypoxia and hyperoxia on the differential expression of VEGF-A iso...
Abstract Dysregulation of VEGF-A bioavailability has been implicated in the development of lung injury/fibrosis, exemplified by Idiopathic Pulmonary Fibrosis (IPF). VEGF-A is a... -
Promoter methylation inhibits expression of tumor suppressor KIBRA in human c...
Abstract Background KIBRA has been suggested as a key regulator of the Hippo signaling pathway, regulating organ size, cell contact inhibition, tissue regeneration as well as... -
Umbilical cord as a long-term source of activatable mesenchymal stromal cells...
Abstract Background Mesenchymal stromal cells (MSCs) are used in over 800 clinical trials mainly due to their immune inhibitory activity. Umbilical cord (UC), the second leading... -
Sprifermin (rhFGF18) modulates extracellular matrix turnover in cartilage exp...
Abstract Background Sprifermin (recombinant human fibroblast growth factor 18) is in clinical development as a potential disease-modifying osteoarthritis drug (DMOAD). In vitro...
