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Oxysterol levels and metabolism in the course of neuroinflammation: insights ...
Abstract Background Oxysterols are cholesterol derivatives that have been suggested to play a role in inflammatory diseases such as obesity, atherosclerosis, or... -
miRNA-23a/CXCR4 regulates neuropathic pain via directly targeting TXNIP/NLRP3...
Abstract Background Chemokine CXC receptor 4 (CXCR4) in spinal glial cells has been implicated in neuropathic pain. However, the regulatory cascades of CXCR4 in neuropathic pain... -
Suppression of CHRN endocytosis by carbonic anhydrase CAR3 in the pathogenesi...
Myasthenia gravis is an autoimmune disorder of the neuromuscular junction manifested as fatigable muscle weakness, which is typically caused by pathogenic autoantibodies against... -
Low back pain and limitations of daily living in Asia: longitudinal findings ...
Abstract Background Low back pain (LBP) is a major cause of disability throughout the world. However, longitudinal evidence to relate low back pain and functional limitations is... -
Global Hypoxia-Ischemia Induced Inflammation and Structural Changes in the Pr...
Abstract Perinatal asphyxia, a condition of impaired gas exchange during birth, leads to fetal hypoxia-ischemia (HI) and is associated with postnatal adverse outcomes including... -
Spontaneous seizure and partial lethality of juvenile Shank3-overexpressing m...
Abstract The SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene encodes core scaffolds in neuronal excitatory postsynapses. SHANK3 duplications have been identified in... -
Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of pa...
Abstract Muscle atrophy with weakness is a core feature of amyotrophic lateral sclerosis (ALS) that has long been attributed to motor neuron loss alone. However, several studies... -
Advancing the pathologic phenotype of giant axonal neuropathy: early involvem...
Abstract Giant axonal neuropathy (GAN; ORPHA: 643; OMIM# 256850) is a rare, hereditary, pediatric neurodegenerative disorder associated with intracellular accumulations of... -
Heme oxygenase-1 promoter region (GT)n polymorphism associates with increased...
Abstract Background Heme oxygenase-1 (HO-1) is a critical cytoprotective enzyme that limits oxidative stress, inflammation, and cellular injury within the central nervous system... -
Musculoskeletal pains and cardiovascular autonomic function in the general No...
Abstract Background Heart rate variability (HRV) and baroreflex sensitivity (BRS) measurements provide means for the objective assessment of cardiovascular autonomic function.... -
HIV induces expression of complement component C3 in astrocytes by NF-κB-depe...
Abstract Background Abnormal activation of the complement system contributes to some central nervous system diseases but the role of complement in HIV-associated neurocognitive... -
Paclitaxel-activated astrocytes produce mechanical allodynia in mice by relea...
Abstract Background Paclitaxel is a widely used and potent chemotherapeutic agent for the treatment of cancer. However, patients receiving paclitaxel often develop an acute pain... -
Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor ...
Abstract Background Three amino acid differences between rodent and human APP affect medically important features, including β-secretase cleavage of APP and Aβ peptide... -
Do fragments and glycosylated isoforms of alpha-1-antitrypsin in CSF mirror s...
Abstract Background Post-translational modifications (PTMs) generate a tremendous protein diversity from the ~ 20,000 protein-coding genes of the human genome. In chronic pain... -
Intermittent peripheral exposure to lipopolysaccharide induces exploratory be...
Abstract Background Consecutive peripheral immune challenges can modulate the responses of brain resident microglia to stimuli. High-fat diet (HFD) intake has been reported to... -
What is the impact of child abuse on gray matter abnormalities in individuals...
Abstract Background Patients with major depressive disorder (MDD) present heterogeneous clinical symptoms, and childhood abuse is associated with deepening of psychopathology.... -
Comorbid and co-occurring conditions in migraine and associated risk of incre...
Abstract Background Migraine has many presumed comorbidities which have rarely been compared between samples with and without migraine. Examining the association between... -
The preventive effect of resiniferatoxin on the development of cold hypersens...
Abstract Background Resiniferatoxin (RTX) is a potent analog of capsaicin and activates transient receptor potential (TRP) vanilloid type (TRPV) 1. In the current study, we... -
Investigation of answer changes on the USMLEÂŽ Step 2 Clinical Knowledge exam...
Abstract Background Examinees often believe that changing answers will lower their scores; however, empirical studies suggest that allowing examinees to change responses may... -
Concordance analysis of microarray studies identifies representative gene exp...
Abstract Background As the popularity of transcriptomic analysis has grown, the reported lack of concordance between different studies of the same condition has become a growing...
