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Are low-value care measures up to the task? A systematic review of the litera...
Abstract Background Reducing low-value care is a core component of healthcare reforms in many Western countries. A comprehensive and sound set of low-value care measures is... -
Microglial depletion and repopulation in brain slice culture normalizes sensi...
Abstract Background Microglia are critical mediators of neuroimmune pathology across multiple neurologic disorders. Microglia can be persistently activated or “primed” by... -
A case report of one vasovagal syncope patient with third-degree atrioventric...
Abstract Background Vasovagal syncope (VVS) is common in children and significantly affects their quality of life. To our knowledge, this the first case report of SCN5A gene... -
Knowledge of pharmacy workers on antihypertensive and anticonvulsant drugs fo...
Abstract Background Pharmacy workers in Bangladesh play an important role in managing pregnancy complications by dispensing, counselling and selling drugs to pregnant women and... -
Selection bias in clinical stroke trials depending on ability to consent
Abstract Background Clinical trials are the hallmark of evidence-based medicine, but recruitment is often challenging, especially in stroke trials investigating patients not... -
Constructing a bilingual website with validated database for Herb and Western...
Abstract Background Concerns have been raised regarding the efficacy and safety resulting from the potential interactions of herbs with Western medications due to the use of... -
Base excess and hematocrit predict response to indomethacin in very low birth...
Abstract Background The treatment of patent ductus arteriosus (PDA) in very low birth weight (VLBW) infants remains a challenge. The ability to predict which infants will... -
Association of statin use and clinical outcomes in heart failure patients: a ...
Abstract Background The role of statins in patients with heart failure (HF) of different levels of left ventricular ejection fraction (LVEF) remains unclear especially in the... -
An open-label, long-term, phase III extension trial of duloxetine in Japanese...
Objectives: We aimed to evaluate the long-term safety and efficacy of duloxetine 60 mg in Japanese patients with fibromyalgia enrolled from a preceding randomized,... -
A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein ...
Abstract Background Tumor suppressor WWOX physically binds p53 and TIAF1 and together induces apoptosis and tumor suppression. To understand the molecular action, here we... -
Opioid substitution treatment and heroin dependent adolescents: reductions in...
Abstract Background Opioid dependence is a major health concern across the world and does also occur in adolescents. While opioid substitution treatment (OST) has been... -
Quantitative benefit-risk assessment of methylprednisolone in multiple sclero...
Abstract Background High-dose short-term methylprednisolone is the recommended treatment in the management of multiple sclerosis relapses, although it has been suggested that...
