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Comparative analyses of the in vivo induction and transmission of α-synuclein...
Abstract α-synuclein (αS) is the major component of several types of brain pathological inclusions that define neurodegenerative diseases termed synucleinopathies. Central... -
Endovascular external carotid artery occlusion for brain selective targeting:...
Abstract Background The choice of an animal model for cerebrovascular research is often determined by the disease subtype to be studied (e.g. ischemic stroke, hemorrhage,... -
Divergent transcriptomic responses underlying the ranaviruses-amphibian inter...
Abstract Background Ranaviruses (family Iridoviridae, nucleocytoplasmic large DNA viruses) have been reported as promiscuous pathogens of cold-blooded vertebrates. Rana grylio... -
Single chip lidar with discrete beam steering by digital micromirror device
A novel method of beam steering enables a large field of view and reliable single chip light detection and ranging (lidar) by utilizing a mass-produced digital micromirror... -
Comparing the reasons for suicide from attempt survivors and their families i...
Abstract Background Family members are key in detecting early suicide warning signs. This study compared the reasons for suicidality as reported by attempt survivors with their... -
Immune signatures for HIV-1 and HIV-2 induced CD4+T cell dysregulation in an ...
Abstract Background HIV-2 infection is characterised by a longer asymptomatic phase and slower AIDS progression than HIV-1 infection. Identifying unique immune signatures... -
Replication competence of virions induced from CD4+ lymphocytes latently infe...
Abstract Latently infected CD4 lymphocytes preclude cure of HIV infection, even with the most effective antiretroviral therapy. The replication competent latent HIV reservoir... -
Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype ...
Abstract Background The use of immunodeficient mice transplanted with human hematopoietic stem cells is an accepted approach to study human-specific infectious diseases such as... -
Prophages and adaptation of Staphylococcus aureus ST398 to the human clinic
Abstract Background It has been suggested that prophages in the ST398 S. aureus clone are responsible for expanding ST398's spectrum of action and increasing its ability to... -
Arenavirus infection correlates with lower survival of its natural rodent hos...
Abstract Background Parasite evolution is hypothesized to select for levels of parasite virulence that maximise transmission success. When host population densities fluctuate,... -
Bridging Two Worlds: Microfluidic Optomechanics
Optomechanical systems that enable strong phonon-photon coupling have been with us for a while but have never been demonstrated with non-solid phases of matter. -
Neural hyperactivity in the amygdala induced by chronic treatment of rats wit...
Abstract Background Patients with medication-overuse headache suffer not only from chronic headache, but often from psychiatric comorbidities, such as anxiety and depression.... -
Internal migration of physicians who graduated in Brazil between 1980 and 2014
Abstract Background The internal migration of physicians from one place to another in the same country can unbalance the supply and distribution of these professionals in... -
Ancient coexistence of norepinephrine, tyramine, and octopamine signaling in ...
Abstract Background Norepinephrine/noradrenaline is a neurotransmitter implicated in arousal and other aspects of vertebrate behavior and physiology. In invertebrates,... -
Assessing Gammapapillomavirus infections of mucosal epithelia with two broad-...
Abstract Background Human papillomaviruses (HPVs) have been divided into mucosal and cutaneous types according to their primary epithelial tissue tropism. However, recent... -
Olfactory coding from the periphery to higher brain centers in the Drosophila...
Abstract Background Odor information is processed through multiple receptor-glomerular channels in the first order olfactory center, the antennal lobe (AL), then reformatted... -
Acceptance of a systematic review as a thesis: survey of biomedical doctoral ...
Abstract Background Systematic reviews (SRs) have been proposed as a type of research methodology that should be acceptable for a graduate research thesis. The aim of this study... -
Age- and gender-specific incidence rates of renal replacement therapy in Japa...
Abstract Background Japan has relatively low incidence rates of renal replacement therapy (RRT) for end-stage kidney disease (ESKD) among those aged 0–19 years, but relatively... -
The Trypanosomatid Pr77-hallmark contains a downstream core promoter element ...
Abstract Background Trypanosomatid genomes are highly colonized by non-LTR retroelements that make up to 5 % of the nuclear genome. These elements are mainly accumulated in the... -
Male sex is strongly associated with IgE-sensitization to airborne but not fo...
Abstract Background Up to half of the population in high-income countries has allergen-specific IgE antibodies. However, data regarding sex differences of IgE-sensitization from...
