-
Development of a promoter shutoff system in <i>Aspergillus oryzae</i> using a...
Promoter shutoff is a general method for analyzing essential genes, but in the fungus Aspergillus oryzae, no tightly repressed promoters have been reported. To overcome the... -
Prevalence and characteristics of older adults with a persistent death wish w...
Abstract Background Some older persons develop a persistent death wish without being severely ill, often referred to as “completed life” or “tiredness of life”. In the... -
Outcomes in randomised controlled trials in prevention and management of cari...
Abstract Background Inconsistent outcome reporting is one significant hurdle to combining results from trials into systematic reviews. Core outcome sets (COS) can reduce this... -
Effects of the Toll-like receptor 7 (TLR7) agonist, AZD8848, on allergen-indu...
Abstract Background Although allergic asthma is a complex area with many interacting factors involved, the ‘hygiene hypothesis’ proposes that a lack of exposure to infection... -
A multicenter randomized controlled trial of surgery alone or surgery with at...
Abstract Background Postoperative cancer recurrence is a major problem following curative surgery. In a previous retrospective study of lung cancer surgery, we reported that... -
Survey indicated that core outcome set development is increasingly including ...
Abstract Background There are numerous challenges in including patients in a core outcome set (COS) study, these can vary depending on the patient group. This study describes... -
Eye irritation testing of nanomaterials using the EpiOcular™ eye irritation t...
Abstract Background Assessment of eye irritation hazard has long been a core requirement in any chemical legislation. Nevertheless, publications focussing on the eye damaging... -
Appendectomy, cholecystectomy and diagnostic laparoscopy conducted before pre...
Abstract Background Non-obstetric surgery conducted during pregnancy may increase the risk of adverse birth outcomes like small for gestational age, preterm birth, and... -
Genes targeted by the Hedgehog-signaling pathway can be regulated by Estrogen...
Abstract Background Nuclear receptor family member, Estrogen related receptor β, and the Hedgehog signal transduction pathway are both reported to relate to tumorigenesis and... -
Development of a core outcome set for diabetes after pregnancy prevention int...
Abstract Background Gestational diabetes mellitus (GDM) increases the risk of adverse short- and long-term outcomes, including development of type 2 diabetes. The US Diabetes... -
Removal of the product from the culture medium strongly enhances free fatty a...
Abstract Background Cyanobacterial mutants engineered for production of free fatty acids (FFAs) secrete the products to the medium and hence are thought to be useful for biofuel... -
Development of a core outcome set for clinical trials in facial aging: study ...
Abstract Background Facial aging is a concern for many patients. Wrinkles, loss of volume, and discoloration are common physical manifestations of aging skin. Genetic heritage,... -
Vasoresponsiveness in patients with heart failure (VASOR): protocol for a pro...
Abstract Background Vasoplegia is a severe complication which may occur after cardiac surgery, particularly in patients with heart failure. It is a result of activation of... -
The whole - genome expression analysis of peripheral blood mononuclear cells ...
Abstract Background Up to 30 % of adults with severe asthma are hypersensitive to aspirin and no unambiguous theory exists which provides a satisfactory explanation for the... -
Periostin involved in the activated hepatic stellate cells-induced progressio...
Abstract Background Incomplete thermal ablation may induce invasiveness of hepatocellular carcinoma (HCC). Here, we investigated whether activated hepatic stellate cells (HSCs)... -
Long-term Safety and Efficacy of Human-Induced Pluripotent Stem Cell (iPS) Gr...
Abstract The U.S. Food and Drug Administration recently approved phase I/II clinical trials for embryonic stem (ES) cell-based retinal pigmented epithelium (RPE)... -
Systematic review of outcome domains and instruments used in clinical trials ...
Abstract Background There is no evidence-based guidance to facilitate design decisions for confirmatory trials or systematic reviews investigating treatment efficacy for adults... -
Impact of faculty development programme on self-efficacy, competency and atti...
Abstract Background Soon after Bhutan’s first medical university was established in 2012, Faculty Development Programmes (FDPs) were adopted for efficient delivery of... -
M1-like tumor-associated macrophages activated by exosome-transferred THBS1 p...
Abstract Background Treatment strategies targeting tumor-associated macrophages (TAMs) have been proposed in cancer areas. The functional alterations of macrophages in the... -
Amorphous silica nanoparticles induce malignant transformation and tumorigene...
Rapid development and deployment of engineered nanomaterials, such as amorphous silica nanoparticles (SiNPs) in various commercial and biomedical applications have raised...
