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Omalizumab in patients with severe asthma and persistent sputum eosinophilia
Abstract Omalizumab, a recombinant humanized monoclonal antibody targeting the IgE molecule, is the first biologic approved for moderate-to-severe allergic asthmatics, who... -
ISSEC: inferring contacts among protein secondary structure elements using de...
Abstract Background The formation of contacts among protein secondary structure elements (SSEs) is an important step in protein folding as it determines topology of protein... -
Buying and selling human eggs: infertility providers’ ethical and other conce...
Abstract Background Egg donor agencies are increasingly being used as part of IVF in the US, but are essentially unregulated, posing critical ethical and policy questions... -
Development of a benchmark tool for cancer centers; results from a pilot exer...
Abstract Background Differences in cancer survival exist between countries in Europe. Benchmarking of good practices can assist cancer centers to improve their services aiming... -
Current infection control practices used in Australian and New Zealand cystic...
Abstract Background The 2013 update of the Infection Prevention and Control (IP&C) Guideline outlined recommendations to prevent the spread of CF respiratory pathogens. We... -
How to improve patient education on deep brain stimulation in Parkinson’s dis...
Abstract Background The introduction of deep brain stimulation (DBS) about 25 years ago provided one of the major breakthroughs in the treatment of Parkinson’s disease (PD).... -
Exploring differences in the use of the statin choice decision aid and diabet...
Abstract Background Shared decision making is essential to patient centered care, but can be difficult for busy clinicians to implement into practice. Tools have been developed... -
MIA-Sig: multiplex chromatin interaction analysis by signal processing and st...
Abstract The single-molecule multiplex chromatin interaction data are generated by emerging 3D genome mapping technologies such as GAM, SPRITE, and ChIA-Drop. These datasets... -
Normalization of a conversation tool to promote shared decision making about ...
Abstract Background Shared decision making (SDM) implementation remains challenging. The factors that promote or hinder implementation of SDM tools for use during the... -
Landscape of gene fusions in epithelial cancers: seq and ye shall find
Abstract Enabled by high-throughput sequencing approaches, epithelial cancers across a range of tissue types are seen to harbor gene fusions as integral to their landscape of... -
Electronic health record tools to assist with children’s insurance coverage: ...
Abstract Background Children with health insurance have increased access to healthcare and receive higher quality care. However, despite recent initiatives expanding children’s... -
DNetDB: The human disease network database based on dysfunctional regulation ...
Abstract Disease similarity study provides new insights into disease taxonomy, pathogenesis, which plays a guiding role in diagnosis and treatment. The early studies were... -
Capturing implementation knowledge: applying focused ethnography to study how...
Abstract Background Bespoke electronic information management systems are being used for large-scale implementation delivery of population health programs. They record sites... -
In vitro and in silico studies of terpenes, terpenoids and related compounds ...
Abstract Background In order to develop new larvicidal agents derived from phytochemicals, the larvicidal activity of fifty molecules that are constituent of essential oils was... -
Grading and assessment of clinical predictive tools for paediatric head injur...
Abstract Background Many clinical predictive tools have been developed to diagnose traumatic brain injury among children and guide the use of computed tomography in the... -
International Analgesia, Sedation, and Delirium Practices: a prospective coho...
Abstract Background While understanding of critical illness and delirium continue to evolve, the impact on clinical practice is often unknown and delayed. Our purpose was to... -
Ready, Set, Change! Development and usability testing of an online readiness ...
Abstract Background To address challenges related to selecting a valid, reliable, and appropriate readiness assessment measure in practice, we developed an online decision... -
In vivo OCT imaging of hard and soft tissue of the oral cavity
We use optical coherence tomography (OCT) to perform a comprehensive program of in vivo and in vitro structural imaging of hard and soft tissues within the oral cavity. We have... -
MaveDB: an open-source platform to distribute and interpret data from multipl...
Abstract Multiplex assays of variant effect (MAVEs), such as deep mutational scans and massively parallel reporter assays, test thousands of sequence variants in a single... -
Robust motion tracking based on adaptive speckle decorrelation analysis of OC...
Speckle decorrelation analysis of optical coherence tomography (OCT) signal has been used in motion tracking. In our previous study, we demonstrated that cross-correlation...
