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Omalizumab in patients with severe asthma and persistent sputum eosinophilia
Abstract Omalizumab, a recombinant humanized monoclonal antibody targeting the IgE molecule, is the first biologic approved for moderate-to-severe allergic asthmatics, who... -
ERα-36 regulates progesterone receptor activity in breast cancer
Abstract Background Alterations in estrogen and progesterone signaling, via their respective receptors, estrogen receptor alpha (ERα) and progesterone receptor (PR),... -
Highly active promoters and native secretion signals for protein production d...
Abstract Background The filamentous ascomycete Aspergillus niger is used in many industrial processes for the production of enzymes and organic acids by batch and fed-batch... -
Examining the role of unmeasured confounding in mediation analysis with genet...
Abstract Background In mediation analysis if unmeasured confounding is present, the estimates for the direct and mediated effects may be over or under estimated. Most methods... -
A novel pyruvate kinase and its application in lactic acid production under o...
Abstract Background Pyruvate kinase (Pyk) catalyzes the generation of pyruvate and ATP in glycolysis and functions as a key switch in the regulation of carbon flux distribution.... -
Identification of non-conserved residues essential for improving the hydrocar...
Abstract Background Cyanobacteria produce hydrocarbons corresponding to diesel fuels by means of aldehyde-deformylating oxygenase (ADO). ADO catalyzes a difficult and unusual... -
Development of a new promoter to avoid the silencing of genes in the producti...
Abstract Background The production of recombinant proteins in mammalian cell lines is one of the most important areas in biopharmaceutical industry. Viral transcriptional... -
Parity predisposes breasts to the oncogenic action of PAPP-A and activation o...
Abstract Background Women who had children at a young age (less than 25) show a reduced overall risk of breast cancer. However, epidemiological studies showed that for all other... -
Light-induced gene expression with photocaged IPTG for induction profiling in...
Abstract Background Inducible expression systems are frequently used for the production of heterologous proteins. Achieving maximum product concentrations requires induction... -
Identification and validation of a Schistosoma japonicum U6 promoter
Abstract Background RNA polymerase III promoters have been widely used to express short hairpin-RNA (shRNA), microRNA (miRNA), and small guide RNA (sgRNA) in gene functional... -
Development of a high-throughput screen to identify small molecule enhancers ...
Abstract Background Duchenne muscular dystrophy (DMD) is caused by loss of sarcolemma connection to the extracellular matrix. Transgenic overexpression of the transmembrane... -
Deciphering how LIP2 and POX2 promoters can optimally regulate recombinant pr...
Abstract Background In recent years, the non-conventional model yeast species Yarrowia lipolytica has received much attention because it is a useful cell factory for producing... -
Air pollution-induced placental epigenetic alterations in early life: a candi...
Particulate matter (PM) exposure during in utero life may entail adverse health outcomes in later-life. Air pollution's adverse effects are known to alter gene expression... -
CYP1A1 methylation mediates the effect of smoking and occupational polycyclic...
Abstract Background Multiple factors, including co-exposure between lifestyle and environmental risks, are important in susceptibility to oxidative DNA damage. However, the... -
New inducible promoter for gene expression and synthetic biology in Yarrowia ...
Abstract Background The oleaginous yeast Yarrowia lipolytica is increasingly used as alternative cell factory for the production of recombinant proteins. At present, several... -
Validating self-reporting of hearing-related symptoms against pure-tone audio...
Objective: To validate self-reported hearing-related symptoms among personnel exposed to moderately high occupational noise levels at an obstetrics clinic. Design: Sensitivity,... -
Patterns of leisure-time physical activity across pregnancy and adverse pregn...
Abstract Background Although leisure-time physical activity (PA) contributes to overall health, including pregnancy health, patterns across pregnancy have not been related to... -
Wnt5a-induced M2 polarization of tumor-associated macrophages via IL-10 promo...
Abstract Background Tumor-associated macrophages (TAMs) in the tumor microenvironment influence tumor initiation, invasion and metastasis. Several studies have shown that Wnt5a... -
Blood transfusion improves renal oxygenation and renal function in sepsis-ind...
Abstract Background The effects of blood transfusion on renal microcirculation during sepsis are unknown. This study aimed to investigate the effect of blood transfusion on... -
Metabolic flux analysis for metabolome data validation of naturally xylose-fe...
Abstract Background Efficient xylose fermentation still demands knowledge regarding xylose catabolism. In this study, metabolic flux analysis (MFA) and metabolomics were used to...
