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Omalizumab in patients with severe asthma and persistent sputum eosinophilia
Abstract Omalizumab, a recombinant humanized monoclonal antibody targeting the IgE molecule, is the first biologic approved for moderate-to-severe allergic asthmatics, who... -
Efficient production of extracellular pullulanase in Bacillus subtilis ATCC60...
Abstract Background Bacillus subtilis has been widely used as a host for heterologous protein expression in food industry. B. subtilis ATCC6051 is an alternative expression host... -
A novel transcription factor specifically regulates GH11 xylanase genes in Tr...
Abstract Background The filamentous fungus Trichoderma reesei is widely utilized in industry for cellulase production, but its xylanase activity must be improved to enhance the... -
Plasma levels of increased miR-195-5p correlates with the sFLT-1 levels in pr...
Although the role of soluble fms-like tyrosine kinase 1 (sFLT-1) in preeclampsia is well-established, the mechanism related to its synthesis remains poorly understood. We... -
Elevated serum iron level is a predictor of prognosis in ICU patients with ac...
Abstract Background Accumulation of iron is associated with oxidative stress, inflammation, and regulated cell death processes that contribute to the development of acute kidney... -
Pharmacological and functional similarities of the human neuropeptide Y syste...
Abstract Background The neuropeptide Y system affects various processes, among others food intake, and is frequently discussed in the context of targeting obesity. Studies in... -
TSS seq based core promoter architecture in blood feeding Tsetse fly (Glossin...
Abstract Background Transcription initiation regulation is mediated by sequence-specific interactions between DNA-binding proteins (transcription factors) and cis-elements,... -
A novel pyruvate kinase and its application in lactic acid production under o...
Abstract Background Pyruvate kinase (Pyk) catalyzes the generation of pyruvate and ATP in glycolysis and functions as a key switch in the regulation of carbon flux distribution.... -
High apolipoprotein M serum levels correlate with chronic obstructive pulmona...
Abstract Background Recently, variations in a component of high-density lipoprotein (HDL), namely apolipoprotein M (apoM), were found to be associated with chronic obstructive... -
Identification of non-conserved residues essential for improving the hydrocar...
Abstract Background Cyanobacteria produce hydrocarbons corresponding to diesel fuels by means of aldehyde-deformylating oxygenase (ADO). ADO catalyzes a difficult and unusual... -
MiR-182-5p and its target HOXA9 in non-small cell lung cancer: a clinical and...
Abstract Background MiR-182-5p, a cancer-related microRNA (miRNA), modulates tumorigenesis and patient outcomes in various human malignances. This study interroted the... -
Identification and validation of a Schistosoma japonicum U6 promoter
Abstract Background RNA polymerase III promoters have been widely used to express short hairpin-RNA (shRNA), microRNA (miRNA), and small guide RNA (sgRNA) in gene functional... -
Development of a high-throughput screen to identify small molecule enhancers ...
Abstract Background Duchenne muscular dystrophy (DMD) is caused by loss of sarcolemma connection to the extracellular matrix. Transgenic overexpression of the transmembrane... -
Efficient and mild swern oxidation using a new sulfoxide and <i>bis</i>(trich...
A new type of sulfoxide, 4-(2-(2-(methylsulfinyl) ethyl)-4-nitrophenyl)- morpholine (I) was designed and prepared in good yield. Upon the combination of I andbis... -
CYP1A1 methylation mediates the effect of smoking and occupational polycyclic...
Abstract Background Multiple factors, including co-exposure between lifestyle and environmental risks, are important in susceptibility to oxidative DNA damage. However, the... -
Inherent bacterial DNA contamination of extraction and sequencing reagents ma...
Abstract Background The advent and use of highly sensitive molecular biology techniques to explore the microbiota and microbiome in environmental and tissue samples have... -
Use of a modified GreenScreen tool to conduct a screening-level comparative h...
Abstract Background Increased concern for potential health and environmental impacts of chemicals, including nanomaterials, in consumer products is driving demand for greater... -
Investigating the landscape of US orphan product approvals
Abstract Background The Orphan Drug Act was enacted in 1983 to encourage the development of drugs for rare diseases. Previous research has attempted to examine the impact of the... -
FCMDAP: using miRNA family and cluster information to improve the prediction ...
Abstract Background Biological experiments have confirmed the association between miRNAs and various diseases. However, such experiments are costly and time consuming.... -
Tau GSTs involved in regulation of leaf abscission by comparison the gene pro...
Abstract Background Glutathione S-transferases (GSTs) have been reported to regulate the plant tolerance to environmental stresses. Many plant GSTs exhibited the roles on...
