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Landscape of gene fusions in epithelial cancers: seq and ye shall find
Abstract Enabled by high-throughput sequencing approaches, epithelial cancers across a range of tissue types are seen to harbor gene fusions as integral to their landscape of... -
A bioinformatics potpourri
Abstract The 16th International Conference on Bioinformatics (InCoB) was held at Tsinghua University, Shenzhen from September 20 to 22, 2017. The annual conference of the... -
MaveDB: an open-source platform to distribute and interpret data from multipl...
Abstract Multiplex assays of variant effect (MAVEs), such as deep mutational scans and massively parallel reporter assays, test thousands of sequence variants in a single... -
The caloric and sugar content of beverages purchased at different store-types...
Abstract Background Following the 2014 sugary drinks tax implementation in Mexico, promising reduction in the volume of purchases of taxed beverages were observed overall and at... -
Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeuti...
Abstract Background The Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) outbreak originating in Wuhan, China, has raised global health concerns and the... -
Can human experts predict solubility better than computers?
Abstract In this study, we design and carry out a survey, asking human experts to predict the aqueous solubility of druglike organic compounds. We investigate whether these... -
Asymptomatic Clostridium difficile colonization: epidemiology and clinical im...
Abstract Background The epidemiology of Clostridium difficile infection (CDI) has changed over the past decades with the emergence of highly virulent strains. The role of... -
Inherent bacterial DNA contamination of extraction and sequencing reagents ma...
Abstract Background The advent and use of highly sensitive molecular biology techniques to explore the microbiota and microbiome in environmental and tissue samples have... -
Correction to: Genetic diversity of the Thao people of Taiwan using Y-chromos...
Following publication of the original article [1], we have been notified that Additional file 3 was published with track changes. -
Antimicrobial peptide similarity and classification through rough set theory ...
Abstract Background Antimicrobial peptides attract considerable interest as novel agents to combat infections. Their long-time potency across bacteria, viruses and fungi as part... -
Promoting deceased organ and tissue donation registration in family physician...
Abstract Background There is a worldwide shortage of organs available for transplant, leading to preventable mortality associated with end-stage organ disease. While most... -
AutoSOME: a clustering method for identifying gene expression modules without...
Abstract Background Clustering the information content of large high-dimensional gene expression datasets has widespread application in "omics" biology. Unfortunately, the... -
HOPS: a quantitative score reveals pervasive horizontal pleiotropy in human g...
Abstract Horizontal pleiotropy, where one variant has independent effects on multiple traits, is important for our understanding of the genetic architecture of human phenotypes.... -
Schmutzi: estimation of contamination and endogenous mitochondrial consensus ...
Abstract Ancient DNA is typically highly degraded with appreciable cytosine deamination, and contamination with present-day DNA often complicates the identification of...
