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cAMP- and cGMP-elevating agents inhibit GPIbα-mediated aggregation but not GP...
Abstract Background The glycoprotein (GP) Ib-IX-V complex is a unique platelet plasma membrane receptor, which is essential for platelet adhesion and thrombus formation. GPIbα,... -
ERα-36 regulates progesterone receptor activity in breast cancer
Abstract Background Alterations in estrogen and progesterone signaling, via their respective receptors, estrogen receptor alpha (ERα) and progesterone receptor (PR),... -
Highly active promoters and native secretion signals for protein production d...
Abstract Background The filamentous ascomycete Aspergillus niger is used in many industrial processes for the production of enzymes and organic acids by batch and fed-batch... -
Parkin deficiency prevents chronic ethanol-induced hepatic lipid accumulation...
Abstract Background Alcohol abuse and alcoholism lead to alcohol liver disease such as alcoholic fatty liver. Parkin is a component of the multiprotein E3 ubiquitin ligase... -
A novel method for the quantification of fatty infiltration in skeletal muscle
Abstract Background Fatty infiltration of the skeletal muscle is a common but poorly understood feature of many myopathies. It is best described in human muscle, where... -
Metabolomics analysis reveals the metabolic and functional roles of flavonoid...
Abstract Background As the predominant secondary metabolic pathway in tea plants, flavonoid biosynthesis increases with increasing temperature and illumination. However, the... -
Identification of non-conserved residues essential for improving the hydrocar...
Abstract Background Cyanobacteria produce hydrocarbons corresponding to diesel fuels by means of aldehyde-deformylating oxygenase (ADO). ADO catalyzes a difficult and unusual... -
Development of a high-throughput screen to identify small molecule enhancers ...
Abstract Background Duchenne muscular dystrophy (DMD) is caused by loss of sarcolemma connection to the extracellular matrix. Transgenic overexpression of the transmembrane... -
Deciphering how LIP2 and POX2 promoters can optimally regulate recombinant pr...
Abstract Background In recent years, the non-conventional model yeast species Yarrowia lipolytica has received much attention because it is a useful cell factory for producing... -
Air pollution-induced placental epigenetic alterations in early life: a candi...
Particulate matter (PM) exposure during in utero life may entail adverse health outcomes in later-life. Air pollution's adverse effects are known to alter gene expression... -
Wnt5a-induced M2 polarization of tumor-associated macrophages via IL-10 promo...
Abstract Background Tumor-associated macrophages (TAMs) in the tumor microenvironment influence tumor initiation, invasion and metastasis. Several studies have shown that Wnt5a... -
Epigenetic regulation of transcription factor promoter regions by low-dose ge...
Abstract Background The phytoestrogen, genistein at low doses nongenomically activates mitogen-activated protein kinase p44/42 (MAPKp44/42) via estrogen receptor alpha (ERα)... -
VEGF-121 plasma level as biomarker for response to anti-angiogenetic therapy ...
Abstract Background Vascular endothelial growth factor (VEGF) isoforms, particularly the diffusible VEGF-121, could play a major role in the response of recurrent glioblastoma... -
Metabolic flux analysis for metabolome data validation of naturally xylose-fe...
Abstract Background Efficient xylose fermentation still demands knowledge regarding xylose catabolism. In this study, metabolic flux analysis (MFA) and metabolomics were used to... -
Glossogyne tenuifolia (Hsiang-ju) extract suppresses T cell activation by inh...
Abstract Background Glossogyne tenuifolia (GT) (Hsiang-ju) is a Chinese herbal medicine previously exhibited an anti-inflammatory activity. This study aimed to investigate the... -
Simvastatin and a Plant Galactolipid Protect Animals from Septic Shock by Reg...
Abstract Sepsis remains a major medical issue despite decades of research. Identification of important inflammatory cascades and key molecular mediators are crucial for... -
Thrombin-induced, TNFR-dependent miR-181c downregulation promotes MLL1 and NF...
Abstract Background Controlling thrombin-driven microglial activation may serve as a therapeutic target for intracerebral hemorrhage (ICH). Here, we investigated microRNA... -
The GLP-1 receptor agonists exenatide and liraglutide activate Glucose transp...
Abstract Aims/hypothesis Potentiation of glucose-induced insulin secretion is the main mechanism of exenatide (EXE) antidiabetic action, however, increased glucose utilization... -
In utero exposure to ultrafine particles promotes placental stress-induced pr...
Abstract Background Exposure to particulate matter (PM) is associated with an adverse intrauterine environment, which can promote adult cardiovascular disease (CVD) risk.... -
Associations of dietary phytosterols with blood lipid profiles and prevalence...
Abstract Background It has been established in RCTs that high dose of phytosterols can significantly reduce blood cholesterol. However, it was uncertain whether low dose of...
