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Cherenkov luminescence imaging is a fast and relevant preclinical tool to ass...
Abstract Purpose Molecular imaging techniques visualise biomarkers for both drug development and personalised medicine. In this field, Cherenkov luminescence imaging (CLI) seems... -
Structural alteration of DNA induced by viral protein R of HIV-1 triggers the...
Abstract Background Viral protein R (Vpr) is an accessory protein of HIV-1, which is potentially involved in the infection of macrophages and the induction of the... -
Association of pre-operative medication use with post-operative delirium in s...
Abstract Background Older patients undergoing surgery tend to have a higher frequency of delirium. Delirium is strongly associated with poor surgical outcomes. This study... -
Interplay between FACT subunit SPT16 and TRIM33 can remodel chromatin at macr...
Abstract Background Cell type-specific use of cis-acting regulatory elements is mediated by the combinatorial activity of transcription factors involved in lineage determination... -
Long-term prenatal exposure to paracetamol is associated with DNA methylation...
Abstract Background Epidemiological studies have shown that long-term exposure to paracetamol during pregnancy is associated with attention-deficit/hyperactivity disorder... -
Characteristics of functional enrichment and gene expression level of human p...
Abstract Background Transcriptional target genes show functional enrichment of genes. However, how many and how significantly transcriptional target genes include functional... -
Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeuti...
Abstract Background The Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) outbreak originating in Wuhan, China, has raised global health concerns and the... -
Microbial community shifts elicit inflammation in the caecal mucosa via the G...
Abstract Background Dietary structure in ruminants is closely connected with the composition of gastrointestinal microbiota. Merging study has shown that dietary induced SARA... -
Childhood traumatization is associated with differences in TRPA1 promoter met...
Abstract Background The construct of multisomatoform disorder (MSD) is a common point of reference for patients in different somatic and psychosomatic specialties and therefore... -
Influence of weaning methods on the diaphragm after mechanical ventilation in...
Abstract Background Mechanical ventilation (MV) is associated with diaphragm weakness, a phenomenon termed ventilator-induced diaphragmatic dysfunction. Weaning should balance... -
The HDAC6/APOBEC3G complex regulates HIV-1 infectiveness by inducing Vif auto...
Abstract Background Human immunodeficiency virus type 1 (HIV-1) has evolved a complex strategy to overcome the immune barriers it encounters throughout an organism thanks to its... -
Evaluation of apoptosis imaging biomarkers in a genetic model of cell death
Abstract Purpose We have previously developed the caspase-based radiotracer, 18F-ICMT-11, for PET imaging to monitor treatment response. We further validated 18F-ICMT-11... -
How central obesity influences intra-abdominal pressure: a prospective, obser...
Abstract Background Intra-abdominal hypertension (IAH) is frequently present in critically ill patients and is an independent predictor for mortality. Better recognition of... -
Kinetic analysis of [18F] altanserin bolus injection in the canine brain usin...
Abstract Background Currently, [18F] altanserin is the most frequently used PET-radioligand for serotonin2A (5-HT2A) receptor imaging in the human brain but has never been... -
Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice
Abstract Background Nur77, a key member of the NR4A receptor subfamily, is involved in the regulation of inflammation and immunity. However, the in vivo regulatory roles of... -
Cogena, a novel tool for co-expressed gene-set enrichment analysis, applied t...
Abstract Background Drug repositioning, finding new indications for existing drugs, has gained much recent attention as a potentially efficient and economical strategy for... -
Compressing gene expression data using multiple latent space dimensionalities...
Abstract Background Unsupervised compression algorithms applied to gene expression data extract latent or hidden signals representing technical and biological sources of... -
Mechanical Ventilation Augments Poly(I:C)-Induced Lung Injury via a WISP1-Int...
Abstract Mechanical ventilation can improve hypoxemia, but can also cause the so-called ventilator-induced lung injury (VILI). Polyinosinic:polycytidylic acid (poly(I:C)), an... -
Establishment of a novel diagnostic test algorithm for human T-cell leukemia ...
Abstract Background The reliable diagnosis of human T-cell leukemia virus type 1 (HTLV-1) infection is important, particularly as it can be vertically transmitted by breast... -
Genome-wide mapping of promoter-anchored interactions with close to single-en...
Abstract Although the locations of promoters and enhancers have been identified in several cell types, we still have limited information on their connectivity. We developed...
