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Cherenkov luminescence imaging is a fast and relevant preclinical tool to ass...
Abstract Purpose Molecular imaging techniques visualise biomarkers for both drug development and personalised medicine. In this field, Cherenkov luminescence imaging (CLI) seems... -
Interplay between FACT subunit SPT16 and TRIM33 can remodel chromatin at macr...
Abstract Background Cell type-specific use of cis-acting regulatory elements is mediated by the combinatorial activity of transcription factors involved in lineage determination... -
Long-term prenatal exposure to paracetamol is associated with DNA methylation...
Abstract Background Epidemiological studies have shown that long-term exposure to paracetamol during pregnancy is associated with attention-deficit/hyperactivity disorder... -
Characteristics of functional enrichment and gene expression level of human p...
Abstract Background Transcriptional target genes show functional enrichment of genes. However, how many and how significantly transcriptional target genes include functional... -
Childhood traumatization is associated with differences in TRPA1 promoter met...
Abstract Background The construct of multisomatoform disorder (MSD) is a common point of reference for patients in different somatic and psychosomatic specialties and therefore... -
How central obesity influences intra-abdominal pressure: a prospective, obser...
Abstract Background Intra-abdominal hypertension (IAH) is frequently present in critically ill patients and is an independent predictor for mortality. Better recognition of... -
Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice
Abstract Background Nur77, a key member of the NR4A receptor subfamily, is involved in the regulation of inflammation and immunity. However, the in vivo regulatory roles of... -
Cogena, a novel tool for co-expressed gene-set enrichment analysis, applied t...
Abstract Background Drug repositioning, finding new indications for existing drugs, has gained much recent attention as a potentially efficient and economical strategy for... -
Compressing gene expression data using multiple latent space dimensionalities...
Abstract Background Unsupervised compression algorithms applied to gene expression data extract latent or hidden signals representing technical and biological sources of... -
Genome-wide mapping of promoter-anchored interactions with close to single-en...
Abstract Although the locations of promoters and enhancers have been identified in several cell types, we still have limited information on their connectivity. We developed... -
Frequent hypermethylation of orphan CpG islands with enhancer activity in cancer
Abstract Background CpG islands (CGIs) are interspersed DNA sequences that have unusually high CpG ratios and GC contents. CGIs are typically located in the promoter of... -
A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coor...
Abstract Background Friend leukemia virus integration 1 (FLI1), an ETS transcription factor family member, acts as an oncogenic driver in hematological malignancies and promotes...
