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Cherenkov luminescence imaging is a fast and relevant preclinical tool to ass...
Abstract Purpose Molecular imaging techniques visualise biomarkers for both drug development and personalised medicine. In this field, Cherenkov luminescence imaging (CLI) seems... -
Structural alteration of DNA induced by viral protein R of HIV-1 triggers the...
Abstract Background Viral protein R (Vpr) is an accessory protein of HIV-1, which is potentially involved in the infection of macrophages and the induction of the... -
Narcissistic traits in young people: understanding the role of parenting and ...
Abstract Background Elevated narcissism in young people often sets up a cascade of interpersonal and mental health challenges, reinforcing the need to understand its... -
Combining the use of Nuss procedure and rib fixation for severe flail chest: ...
Abstract Background Severe flail chest is a life-threatening situation. The Nuss procedure is a new effective treatment for severe flail chest patients who cannot be weaned from... -
The respiratory pressure—abdominal volume curve in a porcine model
Abstract Background Increasing intra-abdominal volume (IAV) can lead to intra-abdominal hypertension (IAH) or abdominal compartment syndrome. Both are associated with raised... -
Influenza A virus enhances ciliary activity and mucociliary clearance via TLR...
Abstract Background Viral respiratory tract infections, such as influenza A virus (IAV), are common and life-threatening illnesses worldwide. The mechanisms by which viruses are... -
Link of dysfunctional attitudes with the negative self-model
Abstract Background Beck’s cognitive theory postulates that dysfunctional attitudes predisposing to depression are formed by early negative experiences. Meanwhile, Bowlby’s... -
Interplay between FACT subunit SPT16 and TRIM33 can remodel chromatin at macr...
Abstract Background Cell type-specific use of cis-acting regulatory elements is mediated by the combinatorial activity of transcription factors involved in lineage determination... -
Long-term prenatal exposure to paracetamol is associated with DNA methylation...
Abstract Background Epidemiological studies have shown that long-term exposure to paracetamol during pregnancy is associated with attention-deficit/hyperactivity disorder... -
Characteristics of functional enrichment and gene expression level of human p...
Abstract Background Transcriptional target genes show functional enrichment of genes. However, how many and how significantly transcriptional target genes include functional... -
Childhood traumatization is associated with differences in TRPA1 promoter met...
Abstract Background The construct of multisomatoform disorder (MSD) is a common point of reference for patients in different somatic and psychosomatic specialties and therefore... -
Respiratory mechanics in infants with severe bronchiolitis on controlled mech...
Abstract Background Analysis of respiratory mechanics during mechanical ventilation (MV) is able to estimate resistive, elastic and inertial components of the working pressure... -
Influence of weaning methods on the diaphragm after mechanical ventilation in...
Abstract Background Mechanical ventilation (MV) is associated with diaphragm weakness, a phenomenon termed ventilator-induced diaphragmatic dysfunction. Weaning should balance... -
Evaluation of apoptosis imaging biomarkers in a genetic model of cell death
Abstract Purpose We have previously developed the caspase-based radiotracer, 18F-ICMT-11, for PET imaging to monitor treatment response. We further validated 18F-ICMT-11... -
How central obesity influences intra-abdominal pressure: a prospective, obser...
Abstract Background Intra-abdominal hypertension (IAH) is frequently present in critically ill patients and is an independent predictor for mortality. Better recognition of... -
Kinetic analysis of [18F] altanserin bolus injection in the canine brain usin...
Abstract Background Currently, [18F] altanserin is the most frequently used PET-radioligand for serotonin2A (5-HT2A) receptor imaging in the human brain but has never been... -
The JAK-STAT Pathway Is Critical in Ventilator-Induced Diaphragm Dysfunction
Abstract Mechanical ventilation (MV) is one of the lynchpins of modern intensive-care medicine and is life saving in many critically ill patients. Continuous ventilator support,... -
Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice
Abstract Background Nur77, a key member of the NR4A receptor subfamily, is involved in the regulation of inflammation and immunity. However, the in vivo regulatory roles of... -
A Nordic survey of CT doses in hybrid PET/CT and SPECT/CT examinations
Abstract Background Computed tomography (CT) scans are routinely performed in positron emission tomography (PET) and single photon emission computed tomography (SPECT)... -
Does CRP predict outcome in bipolar disorder in regular outpatient care?
Abstract Background The association between inflammation and the course of mood disorders is receiving increased attention. This study aims to investigate whether a sub-group of...
