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Genes targeted by the Hedgehog-signaling pathway can be regulated by Estrogen...
Abstract Background Nuclear receptor family member, Estrogen related receptor β, and the Hedgehog signal transduction pathway are both reported to relate to tumorigenesis and... -
Differential expression of E-type prostanoid receptors 2 and 4 in microglia s...
Abstract Background Cyclooxygenase-2 (COX-2) is induced under inflammatory conditions, and prostaglandin E2 (PGE2) is one of the products of COX activity. PGE2 has pleiotropic... -
Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mic...
Abstract Background Nonalcoholic fatty liver disease is one of the most common liver diseases in the world and is a typical hepatic manifestation of metabolic syndrome which is... -
Development of a Core Outcome Set for Studies on Obesity in Pregnant Patients...
Abstract Background Maternal obesity is a risk factor for adverse maternal, fetal, and neonatal events. Numerous clinical trials are currently exploring the effectiveness of... -
The effect of the Xpert MTB/RIF test on the time to MDR-TB treatment initiati...
Abstract Background There are significant delays in initiation of multidrug-resistant tuberculosis (MDR –TB) treatment. The Xpert MTB/RIF test has been shown to reduce the time... -
Subfunctionalization of peroxisome proliferator response elements accounts fo...
Abstract Background In the duplication-degeneration-complementation (DDC) model, a duplicated gene has three possible fates: it may lose functionality through the accumulation... -
Prescription drug use and potential teratogenicity risk among pregnant women ...
Abstract Objective To investigate medications prescribed for pregnant women and their potential teratogenicity risk in Kemisse General Hospital. Result A total of 263 medical... -
Assessment of the safety of antimalarial drug use during early pregnancy (ASA...
Abstract Background A major unresolved safety concern for malaria case management is the use of artemisinin combination therapies (ACTs) in the first trimester of pregnancy.... -
Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrat...
Abstract Background Zyflamend, a blend of herbal extracts, effectively inhibits tumor growth using preclinical models of castrate-resistant prostate cancer mediated in part by... -
The impact of rural outreach programs on medical students’ future rural inten...
Abstract Background Significant investment has been undertaken by many countries into ‘Rural Clinical Training Placement Schemes’ for medical students in order to deal with... -
Tocilizumab in treatment-naïve patients with Takayasu arteritis: TOCITAKA Fre...
Abstract Objectives To assess long-term efficacy of tocilizumab in treatment-naive patients with Takayasu arteritis (TAK). Methods Prospective open-labeled trial in naïve... -
Failure of target attainment of beta-lactam antibiotics in critically ill pat...
Abstract Background Early and appropriate antibiotic dosing is associated with improved clinical outcomes in critically ill patients, yet target attainment remains a challenge.... -
ALternatives To prophylactic Antibiotics for the treatment of Recurrent urina...
Abstract Background At least half of all adult women will experience infective cystitis (urinary tract infection: UTI) at least once in their life and many suffer from repeated... -
The median effective dose (ED50) of cis-Atracurium for laryngeal mask airway ...
Abstract Background In clinical practice, the laryngeal mask airway is an easy-to-use supraglottic airway device. However, the cis-atracurium dosage for laryngeal mask insertion... -
Effects of a multi-strain probiotic supplement for 12 weeks in circulating en...
Abstract Background The present randomized clinical trial characterized the beneficial effects of a multi-strain probiotics supplementation on improving circulating endotoxin... -
The effect of a postpartum IUD intervention on counseling and choice: Evidenc...
Abstract Background The International Federation of Gynaecology and Obstetrics (FIGO), in collaboration with the Sri Lankan College of Obstetrics and Gynaecologists (SLCOG),... -
Contribution of spinal cord glial cells to L. amazonensis experimental infect...
Abstract Background The cellular and molecular pathophysiological mecha\nisms of pain processing in neglected parasitic infections such as leishmaniasis remain unknown. The... -
Early switch from intravenous to oral antibiotic therapy in patients with can...
Abstract Background Neutropenic sepsis remains a common treatment complication for patients receiving systemic anti-cancer treatment. The UK National Institute for Health and... -
Genomic and non-genomic pathways are both crucial for peak induction of neuri...
Abstract Retinoic acid (RA) is the active metabolite of vitamin A and essential for many physiological processes, particularly the induction of cell differentiation. In addition... -
Impact of Xpert MTB/RIF and decentralized care on linkage to care and drug-re...
Abstract Background In 2011, South Africa improved its ability to test for rifampicin-resistant TB (RR-TB) by introducing GeneXpert MTB/RIF. At the same time, the South African...
