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Association between antibiotic consumption and the rate of carbapenem-resista...
Abstract Background This study aimed to investigate the relationship between the rate of carbapenem-resistant Gram-negative bacteria and antibiotic consumption intensity in 153... -
Effects of the Toll-like receptor 7 (TLR7) agonist, AZD8848, on allergen-indu...
Abstract Background Although allergic asthma is a complex area with many interacting factors involved, the ‘hygiene hypothesis’ proposes that a lack of exposure to infection... -
Prevalence and social determinants of psychological distress among people who...
Abstract Background People who use drugs are at a disproportionately higher risk of mental disorders due to prolonged exposure to psychosocial challenges. However, studies on... -
Impact of antibiotic therapy on the development and response to treatment of ...
Abstract Background The gut microbiome impacts the efficacy of immune checkpoint inhibitor (ICI) therapy and the development of ICI-mediated diarrhea and/or colitis (IMDC).... -
HIV-1 integrase resistance associated mutations and the use of dolutegravir i...
Abstract Background Sub-Saharan Africa carries the greatest burden of HIV-infection with increasing drug resistance burden, which requires improved patient management and... -
The magnitude of antibiotic resistance to Helicobacter pylori in Africa and i...
Abstract Background Worldwide Helicobacter pylori (H.pylori) treatment is of great challenge due to increased antibiotic resistance. The burden of H. pylori antibiotic... -
Dexketoprofen/tramadol 25 mg/75 mg: randomised double-blind trial in moderate...
Abstract Background Dexketoprofen trometamol plus tramadol hydrochloride is a new oral combination of two analgesics, which have different mechanisms of action for the treatment... -
Statin drugs to reduce breast cancer recurrence and mortality
Abstract Epidemiologic studies have, variably, shown the concomitant use of statin drugs to be beneficial to cancer outcomes. Statin drugs have been FDA approved for three... -
Assessing Kwa-Zulu-Natalâ s progress towards malaria elimination and its rea...
Abstract Background The South African province of KwaZulu-Natal is rapidly approaching elimination status for malaria with a steady decline in local cases. With the possibility... -
Vasoresponsiveness in patients with heart failure (VASOR): protocol for a pro...
Abstract Background Vasoplegia is a severe complication which may occur after cardiac surgery, particularly in patients with heart failure. It is a result of activation of... -
The whole - genome expression analysis of peripheral blood mononuclear cells ...
Abstract Background Up to 30 % of adults with severe asthma are hypersensitive to aspirin and no unambiguous theory exists which provides a satisfactory explanation for the... -
Statin use in cancer survivors versus the general population: cohort study us...
Abstract Background Cancer survivors may be at increased risk of cardiovascular diseases, but little is known about whether prescribing guidelines for the primary prevention of... -
Expanding harm reduction to include fentanyl urine testing: results from a pi...
Abstract Background Harm reduction has been at the forefront of the response to the opioid overdose public health emergency in British Columbia (BC). The unprecedented number of... -
Changes in prescribed medicines in older patients with multimorbidity and pol...
Abstract Background Treatment complexity rises in line with the number of drugs, single doses, and administration methods, thereby threatening patient adherence. Patients with... -
Prevalence of Schistosoma mansoni infection and the therapeutic efficacy of p...
Abstract Background Intestinal schistosomiasis is one of the neglected tropical parasitic diseases caused by Schistosoma mansoni. Currently, the control measures for the disease... -
The efficacy of varenicline in achieving abstinence among waterpipe tobacco s...
Abstract Background Waterpipe tobacco smoking has increased among youth across the globe including in the US, and it continues as a common and traditional form of smoking... -
Should statin guidelines consider patient preferences? Eliciting preferences ...
Abstract Background Patient preferences are key parameters to evaluate benefit-harm balance of statins for primary prevention but they are not readily available to guideline... -
Methods for assessment of patient adherence to removable orthoses used after ...
Abstract Background Patient adherence to treatment is a key determinant of outcome for healthcare interventions. Whilst non-adherence has been well evidenced in settings such as... -
Pharmacokinetics/pharmacodynamics of chloroquine and artemisinin-based combin...
Abstract Background Activation of hypnozoites of vivax malaria causes multiple clinical relapses, which contribute to the Plasmodium vivax burden and continuing transmission.... -
Benefits of glycopyrrolate/formoterol fumarate metered dose inhaler (GFF MDI)...
Abstract Background The Phase III PINNACLE studies assessed the efficacy and safety of glycopyrrolate/formoterol fumarate metered dose inhaler (GFF MDI), a dual long-acting...
