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Research capacity of Australian and New Zealand emergency medicine departments
Abstract Background Large, multicentre studies are required in emergency medicine to advance clinical care and improve patient outcomes. The Australasian College for Emergency... -
Association between antibiotic consumption and the rate of carbapenem-resista...
Abstract Background This study aimed to investigate the relationship between the rate of carbapenem-resistant Gram-negative bacteria and antibiotic consumption intensity in 153... -
Retrospective analysis in oculocutaneous albinism patients for the 2.7 kb del...
Abstract Background Oculocutaneous albinism (OCA) is an autosomal recessive disorder. A significant portion of OCA patients has been found with a single pathogenic variant... -
Impact of antibiotic therapy on the development and response to treatment of ...
Abstract Background The gut microbiome impacts the efficacy of immune checkpoint inhibitor (ICI) therapy and the development of ICI-mediated diarrhea and/or colitis (IMDC).... -
The magnitude of antibiotic resistance to Helicobacter pylori in Africa and i...
Abstract Background Worldwide Helicobacter pylori (H.pylori) treatment is of great challenge due to increased antibiotic resistance. The burden of H. pylori antibiotic... -
French lyophilized plasma versus normal saline for post-traumatic coagulopath...
Abstract Background Post-trauma bleeding induces an acute deficiency in clotting factors, which promotes bleeding and hemorrhagic shock. However, early plasma administration may... -
Availability, prices, and affordability of selected essential cancer medicine...
Abstract Background More alternatives have become available for the diagnosis and treatment of cancer in low- and middle-income countries. Because of increasing demands,... -
Assessment of research waste part 1: an exemplar from examining study design,...
Abstract Background Research waste is estimated to be very common, but assessments of its prevalence and scope are rare. As an example, we assessed research waste in clinical... -
EWS and FUS bind a subset of transcribed genes encoding proteins enriched in ...
Abstract Background FUS (TLS) and EWS (EWSR1) belong to the FET-protein family of RNA and DNA binding proteins. FUS and EWS are structurally and functionally related and... -
A systematic review: the current status of carbapenem resistance in East Africa
Abstract Objective In this systematic review, we present the molecular epidemiology and knowledge gaps of the carbapenem resistance in East Africa as well as the future probable... -
Ipsilateral proximal and shaft femoral fractures treated with bridge-link typ...
Abstract Background Although many treatments for ipsilateral proximal and shaft femoral fractures have been developed, controversy exists regarding their optimal management. The... -
In vivo analysis of Nef’s role in HIV-1 replication, systemic T cell activati...
Background Nef is a multifunctional HIV-1 protein critical for progression to AIDS. Humans infected with nef(−) HIV-1 have greatly delayed or no disease consequences. We have... -
Multi-center screening of the Pathogen Box collection for schistosomiasis dru...
Abstract Background Over the past five years, as a public service to encourage and accelerate drug discovery for diseases of poverty, the Medicines for Malaria Venture (MMV) has... -
TSS seq based core promoter architecture in blood feeding Tsetse fly (Glossin...
Abstract Background Transcription initiation regulation is mediated by sequence-specific interactions between DNA-binding proteins (transcription factors) and cis-elements,... -
Long-term colonisation with donor bacteriophages following successful faecal ...
Abstract Background Faecal microbiota transplantation (FMT) is used in the treatment of recurrent Clostridium difficile infection.... -
Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrat...
Abstract Background Zyflamend, a blend of herbal extracts, effectively inhibits tumor growth using preclinical models of castrate-resistant prostate cancer mediated in part by... -
Diagnostic uncertainty and urinary tract infection in the emergency departmen...
Abstract Background Suspected urinary tract infection (UTI) syndromes are a common reason for empirical antibiotics to be prescribed in the Emergency Department (ED), but... -
Reduced expression of miR-146a in human bronchial epithelial cells alters neu...
Abstract Background The role of miRNAs in the pathogenesis and determining the phenotypes of asthma is not fully elucidated. miR-146a has been previously shown to suppress... -
YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodeg...
Abstract Background Ginkgo biloba has been reported to possess free radical-scavenging antioxidant activity and anti-inflammatory properties. In our pilot study, YY-1224, a... -
Serum sST2 levels predict severe exacerbation of asthma
Abstract Background Neutrophilic inflammation is associated with poorly controlled asthma. Serum levels of sST2, a soluble IL-33 receptor, increase in neutrophilic lung...
